『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=181431)

EID=181431EID:181431, Map:0, LastModified:2012年10月4日(木) 11:46:05, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Messerli M. Shanta (日) (読)
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2. (英) Ahn Mok-Ryeon (日) (読)
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3. (英) Kunimasa Kazuhiro (日) (読)
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4. (英) Yanagihara Miyako (日) (読)
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5. (英) Tatefuji Tomoki (日) (読)
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6. (英) Hashimoto Ken (日) (読)
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7. (英) Mautner Victor (日) (読)
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8.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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9.堀 均
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10. (英) Kumazawa Shigenori (日) (読)
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11. (英) Kaji Kazuhiko (日) (読)
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12. (英) Ohta Toshiro (日) (読)
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13. (英) Maruta Hiroshi (日) (読)
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題名 (必須): (英) Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) There are mainly three types of propolis whose major anticancer ingredients are entirely different: (1) CAPE (caffeic acid phenethyl ester)-based propolis in Europe, Far East and New Zealand, (2) artepillin C (ARC)-based Brazilian green propolis and (3) Brazilian red propolis. It was shown previously that NF (neurofibromatosis)-associated tumors require the kinase PAK1 for their growth, and CAPE-based propolis extracts such as Bio 30 suppress completely the growth of NF tumors in vivo by blocking PAK1 signaling. Also it was demonstrated that ARC suppresses angiogenesis, suggesting the possibility that ARC also blocks oncogenic PAK1 signaling. Here it is shown for the first time that both ARC and green propolis extract (GPE) indeed block the PAK1 signaling selectively, without affecting another kinase known as AKT. Furthermore, it was confirmed that ARC as well as GPE suppress almost completely the growth of human NF tumor xenografts in mice, as does Bio 30. These results suggest that both CAPE-based and ARC-based propolis extracts are natural anti-PAK1 remedies and could be among the first effective NF therapeutics available on the market. Since more than 70% of human cancers such as breast and prostate cancers require the kinase PAK1 for their growth, it is quite possible that GPE could be potentially useful for the treatment of these cancers, as is Bio 30.  (日)    [継承]
キーワード (推奨): 1. (英) artepillin C (日) (読) [継承]
2. (英) Brazilian green propolis (日) (読) [継承]
3. (英) PAK1 (日) (読) [継承]
4. (英) neurofibromatosis (日) (読) [継承]
発行所 (推奨): (英) John Wiley & Sons, Ltd. (日) (読) [継承]
誌名 (必須): Phytotherapy Research ([John Wiley & Sons, Inc.])
(pISSN: 0951-418X, eISSN: 1099-1573)

ISSN (任意): 1099-1573
ISSN: 0951-418X (pISSN: 0951-418X, eISSN: 1099-1573)
Title: Phytotherapy research : PTR
Title(ISO): Phytother Res
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 423 427 [継承]
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年月日 (必須): 西暦 2009年 3月 末日 (平成 21年 3月 末日) [継承]
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DOI (任意): 10.1002/ptr.2658    (→Scopusで検索) [継承]
PMID (任意): 19003952    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Marine Biological Laboratory, Woods Hole, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, Non-P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Shanta M. Messerli, Mok-Ryeon Ahn, Kazuhiro Kunimasa, Miyako Yanagihara, Tomoki Tatefuji, Ken Hashimoto, Victor Mautner, Yoshihiro Uto, Hitoshi Hori, Shigenori Kumazawa, Kazuhiko Kaji, Toshiro Ohta and Hiroshi Maruta : Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice, Phytotherapy Research, Vol.23, No.3, 423-427, 2009.
欧文冊子 ● Shanta M. Messerli, Mok-Ryeon Ahn, Kazuhiro Kunimasa, Miyako Yanagihara, Tomoki Tatefuji, Ken Hashimoto, Victor Mautner, Yoshihiro Uto, Hitoshi Hori, Shigenori Kumazawa, Kazuhiko Kaji, Toshiro Ohta and Hiroshi Maruta : Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice, Phytotherapy Research, Vol.23, No.3, 423-427, 2009.

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