『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (紀要その他) [継承]
言語 (必須): 日本語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島文理大学 [継承]
著者 (必須): 1. (英) (日) 西岡 麻未子 (読)
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[継承]
2. (英) (日) 梅原 麻子 (読)
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3.小畑 利之
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4.塩田 洋
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5.蛯名 洋介
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6.橋田 誠一 ([宮崎医科大学])
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題名 (必須): (英) Development of the Diabetic Risk Evaluation using Resistin and Insulin Receptor-alpha in Urine and the Application to Exercise/Nutrition Education  (日) 尿中レジスチン及び遊離インスリン受容体αによる糖尿病リスク指標の構築   [継承]
副題 (任意):
要約 (任意): (英) Aim: We want to be able to detect diabetic risky subjects early, and to prevent the onset of diabetes mellitus by performing exercise guidance and offering nutritional education to them. Methods: Two ultrasensitve immunoassays (immune complex transfer enzyme immunoassay; ICT-EIA) for resistin and soluble insulin receptor-a (sIRα) were developed. Urine samples from the patients of diabetes mellitus (DM; n=70), the non-diabetes obese subjects (NDMO; n=43) and the non-diabetes non-obese subjects (NDMNO; n=78) were measured resistin and sIRα using ICT-EIAs. Results: Detection limits of ICT-EIA for resistin and sIRa were 2pg/ml and 0.05pg/ml, respectively. It is possible to measure resistin and sIRa in the urine directly. Resistin in the urine from DM, NDMO and NDMNO were 30.0±36.2, 15.4±17.2 and 17.8±17.4 ng/mg of creatinine, respectively. The urine concentrations of resistin in DM were significantly higher than in the non-diabetes subjects (NDMO and NDMNO) (P<0.05). sIRa in the urine from DM, NDMO and NDMNO were 11.4±21.8, 1.9±1.1 and 1.3±0.8 pg/mg of creatinine, respectively. The urine concentrations of sIRa in DM were significantly higher than in NDM and NDMNO (P<0.001 and P<0.001), respectively. Furthermore, resistin in the urine was positively correlated to sIRa, in the urine. Conclusion: Both resistin and sIRoc in the urine are good markers for the risk of diabetes mellitus. As a result, these markers will be effective for the evaluation of exercise guidance and nutritional education.  (日)    [継承]
キーワード (推奨):
発行所 (推奨): 徳島文理大学 [継承]
誌名 (必須): 徳島文理大学研究紀要 ([徳島文理大学])
(pISSN: 0286-9829)

ISSN (任意): 0286-9829
ISSN: 0286-9829 (pISSN: 0286-9829, eISSN: 2432-4248)
Title: 徳島文理大学研究紀要
Supplier: 徳島文理大学
 (Webcat Plus  (医中誌Web  (J-STAGE (No Scopus information.)
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年月日 (必須): 西暦 2008年 9月 初日 (平成 20年 9月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/110007147051/ [継承]
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NAID (任意): 110007147051 [継承]
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標準的な表示

和文冊子 ● 西岡 麻未子, 梅原 麻子, 小畑 利之, 塩田 洋, 蛯名 洋介, 橋田 誠一 : 尿中レジスチン及び遊離インスリン受容体αによる糖尿病リスク指標の構築, 徳島文理大学研究紀要, Vol.76, 1-19, 2008年.
欧文冊子 ● 西岡 麻未子, 梅原 麻子, Toshiyuki Obata, Hiroshi Shiota, Yousuke Ebina and Seiichi Hashida : Development of the Diabetic Risk Evaluation using Resistin and Insulin Receptor-alpha in Urine and the Application to Exercise/Nutrition Education, Research bulletin of Tokushima Bunri University, Vol.76, 1-19, 2008.

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