| ○種別 (必須): | □ | 学術論文 (紀要その他)
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| ○言語 (必須): | □ | 日本語
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○組織 (推奨): | 1. | 徳島文理大学
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| ○著者 (必須): | 1. | (英) (日) 西岡 麻未子 (読)
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| 2. | (英) (日) 梅原 麻子 (読)
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| 3. | 小畑 利之
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| 4. | 塩田 洋
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| 5. | 蛯名 洋介
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| 6. | 橋田 誠一 ([宮崎医科大学])
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| ○題名 (必須): | □ | (英) Development of the Diabetic Risk Evaluation using Resistin and Insulin Receptor-alpha in Urine and the Application to Exercise/Nutrition Education (日) 尿中レジスチン及び遊離インスリン受容体αによる糖尿病リスク指標の構築
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| ○要約 (任意): | □ | (英) Aim: We want to be able to detect diabetic risky subjects early, and to prevent the onset of diabetes mellitus by performing exercise guidance and offering nutritional education to them. Methods: Two ultrasensitve immunoassays (immune complex transfer enzyme immunoassay; ICT-EIA) for resistin and soluble insulin receptor-a (sIRα) were developed. Urine samples from the patients of diabetes mellitus (DM; n=70), the non-diabetes obese subjects (NDMO; n=43) and the non-diabetes non-obese subjects (NDMNO; n=78) were measured resistin and sIRα using ICT-EIAs. Results: Detection limits of ICT-EIA for resistin and sIRa were 2pg/ml and 0.05pg/ml, respectively. It is possible to measure resistin and sIRa in the urine directly. Resistin in the urine from DM, NDMO and NDMNO were 30.0±36.2, 15.4±17.2 and 17.8±17.4 ng/mg of creatinine, respectively. The urine concentrations of resistin in DM were significantly higher than in the non-diabetes subjects (NDMO and NDMNO) (P<0.05). sIRa in the urine from DM, NDMO and NDMNO were 11.4±21.8, 1.9±1.1 and 1.3±0.8 pg/mg of creatinine, respectively. The urine concentrations of sIRa in DM were significantly higher than in NDM and NDMNO (P<0.001 and P<0.001), respectively. Furthermore, resistin in the urine was positively correlated to sIRa, in the urine. Conclusion: Both resistin and sIRoc in the urine are good markers for the risk of diabetes mellitus. As a result, these markers will be effective for the evaluation of exercise guidance and nutritional education. (日)
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| ○発行所 (推奨): | □ | 徳島文理大学
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| ○誌名 (必須): | □ | 徳島文理大学研究紀要 ([徳島文理大学])
(pISSN: 0286-9829)
| ○ISSN (任意): | □ | 0286-9829
ISSN: 0286-9829
(pISSN: 0286-9829) Title: 徳島文理大学研究紀要Supplier: 徳島文理大学 (Webcat Plus)
(医中誌Web)
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| ○巻 (必須): | □ | 76
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| ○号 (必須): | □ |
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| ○頁 (必須): | □ | 1 19
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| ○年月日 (必須): | □ | 西暦 2008年 9月 初日 (平成 20年 9月 初日)
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| ○URL (任意): | □ | http://ci.nii.ac.jp/naid/110007147051/
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| ○NAID (任意): | □ | 110007147051
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