『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=179790)

EID=179790EID:179790, Map:0, LastModified:2014年2月28日(金) 15:45:51, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[木戸 博], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域]) [継承]
著者 (必須): 1.水野 大
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kubo Itsuka (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Ide-Kurihara Mikiko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Ichinomiya Tomoko (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen  (日)    [継承]
副題 (任意):
要約 (任意): (英) The intranasal administration of influenza hemagglutinin (HA) vaccine with Surfacten, a modified pulmonary surfactant free of antigenic c-type lectins, as a mucosal adjuvant induced the highest protective mucosal immunity in the airway. The intranasal immunization of mice with HA vaccine (0.2 microg)-Surfacten (0.2 microg) selectively induced the neutralizing anti-HA IgA, but not IgG, and conferred nearly maximal protection in the airway, without inducing a systemic response. In contrast, intranasal inoculation of vaccine with 0.2 microg of the potent mucosal adjuvant cholera toxin B* (CT-B*), prepared by adding 0.2% native CT to the B subunit of CT, induced both anti-HA IgA and IgG in the airway and in the serum. The intranasal administration of HA vaccine alone induced a limited amount of mucosal IgA against influenza virus. Although the s.c. administration of HA vaccine prominently induced serum IgG and IgA, Surfacten and CT-B* did not enhance their induction, and the concentrations of Abs leaking into the airways were insufficient to prevent viral multiplication. The intranasal administration of HA-Surfacten stimulated the expression of MHC class II, CD40, and CD86 molecules in the CD11c-positive cells isolated from the nasal mucosa, but not the expression of cells from the lungs or spleens. Lymphocytes isolated from the airway mucosa after intranasal HA-Surfacten immunization prominently induced TGF-beta1 which, compared with inoculation without Surfacten, promoted an Ag-specific mucosal IgA response. Surfacten alone, however, did not induce TGF-beta1. Our observations suggest that Surfacten, by mimicking the natural surfactant, is an effective mucosal adjuvant in the process of airway immunization.  (日)    [継承]
キーワード (推奨): 1. (英) Administration, Intranasal (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Antibodies, Viral (日) (読) [継承]
4. (英) Antigen-Presenting Cells (日) (読) [継承]
5. (英) Antigens, Viral (日) (読) [継承]
6.細胞質分裂 (cytokinesis) [継承]
7. (英) Dose-Response Relationship, Immunologic (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Hemagglutinin Glycoproteins, Influenza Virus (日) (読) [継承]
10. (英) Immunity, Mucosal (日) (読) [継承]
11. (英) Immunoglobulin A, Secretory (日) (読) [継承]
12. (英) Immunoglobulin G (日) (読) [継承]
13. (英) Immunologic Factors (日) (読) [継承]
14. (英) Influenza A virus (日) (読) [継承]
15. (英) Influenza Vaccines (日) (読) [継承]
16. (英) Mice (日) (読) [継承]
17. (英) Mice, Inbred BALB C (日) (読) [継承]
18. (英) Nasal Mucosa (日) (読) [継承]
19. (英) Neutralization Tests (日) (読) [継承]
20. (英) Pulmonary Surfactants (日) (読) [継承]
21. (英) Transforming Growth Factor beta (日) (読) [継承]
22. (英) Transforming Growth Factor beta1 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 176 [継承]
(必須): 2 [継承]
(必須): 1122 1130 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 1月 15日 (平成 18年 1月 15日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 16394001    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000234553800055 [継承]
Scopus (任意): 2-s2.0-30744461365 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: In Vitro  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Dai Mizuno, Itsuka Kubo, Mikiko Ide-Kurihara, Tomoko Ichinomiya and Hiroshi Kido : Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen, The Journal of Immunology, Vol.176, No.2, 1122-1130, 2006.
欧文冊子 ● Dai Mizuno, Itsuka Kubo, Mikiko Ide-Kurihara, Tomoko Ichinomiya and Hiroshi Kido : Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen, The Journal of Immunology, Vol.176, No.2, 1122-1130, 2006.

関連情報

Number of session users = 1, LA = 1.09, Max(EID) = 383267, Max(EOID) = 1024361.