| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.疾患酵素学研究センター (2007年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.次世代酵素学研究領域])
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| ○著者 (必須): | 1. | 水野 大
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Kubo Itsuka (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | (英) Ide-Kurihara Mikiko (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | (英) Ichinomiya Tomoko (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | 木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Modified pulmonary surfactant is a potent adjuvant that stimulates the mucosal IgA production in response to the influenza virus antigen (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The intranasal administration of influenza hemagglutinin (HA) vaccine with Surfacten, a modified pulmonary surfactant free of antigenic c-type lectins, as a mucosal adjuvant induced the highest protective mucosal immunity in the airway. The intranasal immunization of mice with HA vaccine (0.2 microg)-Surfacten (0.2 microg) selectively induced the neutralizing anti-HA IgA, but not IgG, and conferred nearly maximal protection in the airway, without inducing a systemic response. In contrast, intranasal inoculation of vaccine with 0.2 microg of the potent mucosal adjuvant cholera toxin B* (CT-B*), prepared by adding 0.2% native CT to the B subunit of CT, induced both anti-HA IgA and IgG in the airway and in the serum. The intranasal administration of HA vaccine alone induced a limited amount of mucosal IgA against influenza virus. Although the s.c. administration of HA vaccine prominently induced serum IgG and IgA, Surfacten and CT-B* did not enhance their induction, and the concentrations of Abs leaking into the airways were insufficient to prevent viral multiplication. The intranasal administration of HA-Surfacten stimulated the expression of MHC class II, CD40, and CD86 molecules in the CD11c-positive cells isolated from the nasal mucosa, but not the expression of cells from the lungs or spleens. Lymphocytes isolated from the airway mucosa after intranasal HA-Surfacten immunization prominently induced TGF-beta1 which, compared with inoculation without Surfacten, promoted an Ag-specific mucosal IgA response. Surfacten alone, however, did not induce TGF-beta1. Our observations suggest that Surfacten, by mimicking the natural surfactant, is an effective mucosal adjuvant in the process of airway immunization. (日)
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| ○キーワード (推奨): | 1. | (英) Administration, Intranasal (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Antibodies, Viral (日) (読)
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| 4. | (英) Antigen-Presenting Cells (日) (読)
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| 5. | (英) Antigens, Viral (日) (読)
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| 6. | 細胞質分裂 (cytokinesis)
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| 7. | (英) Dose-Response Relationship, Immunologic (日) (読)
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| 8. | (英) Female (日) (読)
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| 9. | (英) Hemagglutinin Glycoproteins, Influenza Virus (日) (読)
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| 10. | (英) Immunity, Mucosal (日) (読)
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| 11. | (英) Immunoglobulin A, Secretory (日) (読)
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| 12. | (英) Immunoglobulin G (日) (読)
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| 13. | (英) Immunologic Factors (日) (読)
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| 14. | (英) Influenza A virus (日) (読)
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| 15. | (英) Influenza Vaccines (日) (読)
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| 16. | (英) Mice (日) (読)
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| 17. | (英) Mice, Inbred BALB C (日) (読)
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| 18. | (英) Nasal Mucosa (日) (読)
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| 19. | (英) Neutralization Tests (日) (読)
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| 20. | (英) Pulmonary Surfactants (日) (読)
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| 21. | (英) Transforming Growth Factor beta (日) (読)
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| 22. | (英) Transforming Growth Factor beta1 (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 0022-1767
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: American Association of Immunologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 176
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 1122 1130
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2006年 1月 15日 (平成 18年 1月 15日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 16394001 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000234553800055
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| ○Scopus (任意): | □ | 2-s2.0-30744461365
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Division of Enzyme Chemistry, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: In Vitro (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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