『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=179781EID:179781, Map:0, LastModified:2014年2月4日(火) 11:49:48, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[センター長]/[徳島大学.疾患酵素学研究センター]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.大阪市立大学大学院 [継承]
著者 (必須): 1.水野 大
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[継承]
2. (英) Hiroi Toyoko (日) (読)
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[継承]
3. (英) Kishimoto Wataru (日) (読)
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[継承]
4. (英) Imaoka Susumu (日) (読)
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[継承]
5. (英) Funae Yoshihiko (日) (読)
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[継承]
題名 (必須): (英) Regulation of CYP2D expression in rat brain by toluene.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We investigated the expressional regulation of cytochrome P450 (CYP) 2D isoforms in rat brain by toluene. Toluene (10 mmol/kg) was injected intraperitoneally into male rats daily for 3 days. CYP2D4 level in the brain was determined by Western blotting. The level of CYP2D4 in the brain and the catalytic activity specific for this isoform were significantly increased by toluene administration. The expressions of CYP2D mRNAs in the brain were quantified by real time PCR. The mRNA level of CYP2D4 increased similar to the expression of the protein and enzymatic activity. These results showed that CYP2D4 was transcriptionally induced by toluene administration for 3 days. This is the first report that subacute exposure to toluene activated the expression of CYP2D4 mRNA in the brain. The response of CYP2D4 expression to toluene is thought to relates to the regulation of the physiological and pharmacological functions of CYP2D isoforms in the brain.  (日)    [継承]
キーワード (推奨): 1. (英) CYP2D4 (日) (読) [継承]
2. (英) Brain (日) (読) [継承]
3. (英) Induction (日) (読) [継承]
4. (英) Toluene (日) (読) [継承]
5. (英) Rat (日) (読) [継承]
発行所 (推奨): 大阪市立大学 [継承]
誌名 (必須): Osaka City Medical Journal ([大阪市立大学])
(pISSN: 0030-6096)

ISSN (任意): 0030-6096
ISSN: 0030-6096 (pISSN: 0030-6096)
Title: Osaka city medical journal
Title(ISO): Osaka City Med J
Supplier: 大阪市立大学
Publisher: Osaka-Shiritsu Daigaku
 (NLM Catalog  (Webcat Plus  (医中誌Web  (Scopus (Scopus information is found. [need login])
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(必須): 149 [継承]
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(必須): 49 56 [継承]
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年月日 (必須): 西暦 2003年 6月 初日 (平成 15年 6月 初日) [継承]
URL (任意): http://ci.nii.ac.jp/naid/110000024382/ [継承]
DOI (任意):
PMID (任意): 14703099    (→Scopusで検索) [継承]
NAID (任意): 110000024382 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Chemical Biology, Osaka City University Medical School, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Dai Mizuno, Toyoko Hiroi, Wataru Kishimoto, Susumu Imaoka and Yoshihiko Funae : Regulation of CYP2D expression in rat brain by toluene., Osaka City Medical Journal, Vol.149, No.1, 49-56, 2003.
欧文冊子 ● Dai Mizuno, Toyoko Hiroi, Wataru Kishimoto, Susumu Imaoka and Yoshihiko Funae : Regulation of CYP2D expression in rat brain by toluene., Osaka City Medical Journal, Vol.149, No.1, 49-56, 2003.

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