『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=179119)

EID=179119EID:179119, Map:0, LastModified:2017年3月22日(水) 14:25:51, Operator:[有澤 孝吉], Avail:TRUE, Censor:0, Owner:[有澤 孝吉], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.日吉 峰麗
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Konishi Hiroaki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.上村 浩一
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Matsuzaki Hideki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Tsukamoto Hideo (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Sugimoto Ryusuke (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.武田 英雄 ([徳島大学.大学院医歯薬学研究部.医学域.総合研究支援センター])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8. (英) Dakeshita Satoru (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9. (英) Kitayama Atsushi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
10. (英) Takami Hidenobu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
11. (英) Sawachika Fusakazu (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
12.木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
13.有澤 孝吉
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) D-dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride  (日)    [継承]
副題 (任意):
要約 (任意): (英) Carbon tetrachloride (CCl4) is known to induce liver damage. Animal experiments with CCl4 injections have revealed many findings, especially mechanisms of liver damage and liver regeneration. Recently, proteomic approaches have been introduced in various studies to evaluate the quantitative and qualitative changes in the comprehensive proteome level. The aim of this research is to elucidate the key protein for liver damage, liver protection and liver regeneration by using proteomic techniques. 50 % (v/v) CCl4 in corn oil was administered intraperitoneally to adult male rats at a dose of 4ml/kg body weight. Approximately 24h after the injection, the liver was removed and extracted proteins were analyzed with cleavable isotope coded affinity tag (cICAT) reagents, two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). A twelvefold increase in D-dopachrome tautomerase (DDT) was indicated. This enzyme has been reported to be involved in the biosynthesis of melanin, an antioxidant. According to the histological analysis, melanin levels were increased in un-damaged hepatocytes of CCl4-treated rats. These results suggest that the increase in DDT is a response to liver damage, accelerates melanin biosynthesis and protects the liver from oxidative stress induced by CCl4.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3. (英) Body Weight (日) (読) [継承]
4. (英) COS Cells (日) (読) [継承]
5. (英) Carbon Tetrachloride Poisoning (日) (読) [継承]
6. (英) Cercopithecus aethiops (日) (読) [継承]
7. (英) Cloning, Molecular (日) (読) [継承]
8. (英) DNA, Complementary (日) (読) [継承]
9. (英) Drug-Induced Liver Injury (日) (読) [継承]
10. (英) Genetic Vectors (日) (読) [継承]
11. (英) Intramolecular Oxidoreductases (日) (読) [継承]
12. (英) Liver (日) (読) [継承]
13. (英) Male (日) (読) [継承]
14. (英) Mass Spectrometry (日) (読) [継承]
15. (英) Melanins (日) (読) [継承]
16. (英) Organ Size (日) (読) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Rats, Wistar (日) (読) [継承]
19. (英) Transfection (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Toxicology ([Elsevier Science])
(pISSN: 0300-483X, eISSN: 1879-3185)

ISSN (任意): 0300-483X
ISSN: 0300-483X (pISSN: 0300-483X, eISSN: 1879-3185)
Title: Toxicology
Title(ISO): Toxicology
Publisher: Elsevier Ireland Ltd
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 255 [継承]
(必須): 1,2 [継承]
(必須): 6 14 [継承]
都市 (任意):
年月日 (必須): 西暦 2009年 2月 初日 (平成 21年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.tox.2008.09.016    (→Scopusで検索) [継承]
PMID (任意): 18930782    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意): 000262798100002 [継承]
Scopus (任意):
評価値 (任意):
被引用数 (任意): 13 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Preventive Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima 770-8503, Japan. hiyoshi@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mineyoshi Hiyoshi, Hiroaki Konishi, Hirokazu Uemura, Hideki Matsuzaki, Hideo Tsukamoto, Ryusuke Sugimoto, Hideo Takeda, Satoru Dakeshita, Atsushi Kitayama, Hidenobu Takami, Fusakazu Sawachika, Hiroshi Kido and Kokichi Arisawa : D-dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride, Toxicology, Vol.255, No.1,2, 6-14, 2009.
欧文冊子 ● Mineyoshi Hiyoshi, Hiroaki Konishi, Hirokazu Uemura, Hideki Matsuzaki, Hideo Tsukamoto, Ryusuke Sugimoto, Hideo Takeda, Satoru Dakeshita, Atsushi Kitayama, Hidenobu Takami, Fusakazu Sawachika, Hiroshi Kido and Kokichi Arisawa : D-dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride, Toxicology, Vol.255, No.1,2, 6-14, 2009.

関連情報

Number of session users = 2, LA = 0.37, Max(EID) = 405283, Max(EOID) = 1099309.