| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.病態予防医学講座 (2004年4月1日〜)
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| ○著者 (必須): | 1. | (英) Soda Akira (日) 荘田 彰 (読) そうだ あきら
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| 2. | 池原 敏孝 ([徳島文理大学])
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| 3. | 木内 陽介
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| 4. | 吉﨑 和男
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| ○題名 (必須): | □ | (英) Effects of exposure to an extremely low frequency-electromagnetic field on the cellular collagen with respect to signaling pathways in osteoblast-like cells. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The effect of exposure to extremely low frequency-electromagnetic field (ELF-EMF: 3 mT, 60 Hz) on differentiation of mouse osteoblast-like MC3T3-E1 cells was examined together with addition of insulin-like growth factor I (IGF-I). As a marker of the differentiation, the cellular collagen content was determined by the absorbance of Sirius red-stained cells measured at the wavelength of 510-520 nm with an imaging microspectroscopy. Exposure to ELF-EMF increased significantly the collagen in the cells. Treatment with PD98059, an inhibitor of extracellular signal-regulated kinase 1/2 (ERK1/2) activation, reduced the collagen in all of the cells examined on control, IGF-I addition and ELF-EMF exposure, however, PD98059 did not prevent the increase in the collagen caused by ELF-EMF exposure, and IGF-I also increased the collagen in the presence of the inhibitor. When phosphatidylinositol 3-kinase (PI3K) pathway was inhibited by LY294002, the increase in collagen induced by ELF-EMF exposure was accelerated, however, the increase in collagen observed by IGF-I addition was suppressed. Treatment with SB203580, an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), suppressed the increase in the collagen induced by ELF-EMF exposure, whereas IGF-I addition increased the collagen in the presence of the inhibitor. These results suggested that collagen synthesis stimulated by ELF-EMF exposure was carried out by the participation of p38 MAPK pathway, and that PI3K pathway may have the role to suppress the collagen synthesis induced by ELF-EMF exposure, and that the suppression of the PI3K pathway may allow the acceleration of the collagen synthesis. (日)
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| ○キーワード (推奨): | 1. | (英) ELF-EMF (日) (読)
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| 2. | (英) ERK1/2 (日) (読)
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| 3. | (英) PI3K (日) (読)
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| 4. | コラーゲン (collagen)
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| 5. | 骨芽細胞 (osteoblast)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1349-6867
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
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(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 55
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| ○号 (必須): | □ | 3,4
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| ○頁 (必須): | □ | 267 278
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 9月 初日 (平成 20年 9月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.55.267 (→Scopusで検索)
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| ○PMID (任意): | □ | 18797142 (→Scopusで検索)
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| ○Scopus (任意): | □ | 2-s2.0-56749174709
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| ○機関リポジトリ : | □ | 110870
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Physiology, Pathophysiological Preventive Medicine, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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