『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=178773)

EID=178773EID:178773, Map:0, LastModified:2012年9月2日(日) 17:16:50, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[近久 幸子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Koyomi Miyazaki (日) (読)
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2. (英) Miyuki Wakabayashi (日) (読)
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3.近久 幸子 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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4.勢井 宏義 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.生理系.統合生理学])
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5.石田 直理雄
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題名 (必須): (英) PER2 controls circadian periods through nuclear localization in the suprachiasmatic nucleus  (日)    [継承]
副題 (任意):
要約 (任意): (英) Molecular circadian clock regulation engages a negative feedback loop comprising components of the negative limb, PERs and CRYs. In addition to the rhythmic transcriptional regulation of clock genes, controlled subcellular localization might contribute to the molecular mechanism of the mammalian circadian clock. To address this issue, we generated transgenic (TG) mice lines harboring either rat PER2 (rPER2) with a deleted nuclear localizing domain [NLD(-)] or intact PER2. In comparison with wild-type (WT) control, the period of the circadian locomotor rhythm in TG mice over-expressing NLD(-) PER2 was longer, while that in TG mice over-expressing intact PER2 was shorter. The nuclear entry of endogenous PER2, CRY1 and CRY2 was delayed in the suprachiasmatic nucleus (SCN) of NLD(-) PER2 TG mice under constant darkness, whereas that of mouse PER2 (mPER2) is accelerated in the SCN of intact PER2 TG mice. Under constant light, the locomotor activity of NLD(-) PER2 TG mice became arrhythmic, whereas WT animals remained rhythmic. These data indicate that PER2 controls circadian periods through nuclear localization in the SCN. In addition, sleep architecture was also affected in intact PER2 TG mice, suggesting PER2 can modulate a sleep molecular mechanism.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Body Temperature (日) (読) [継承]
3. (英) COS Cells (日) (読) [継承]
4. (英) Cell Cycle Proteins (日) (読) [継承]
5. (英) Cell Nucleus (日) (読) [継承]
6. (英) Cercopithecus aethiops (日) (読) [継承]
7. (英) Circadian Rhythm (日) (読) [継承]
8. (英) Cryptochromes (日) (読) [継承]
9. (英) Flavoproteins (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Models, Biological (日) (読) [継承]
12. (英) Nuclear Localization Signals (日) (読) [継承]
13. (英) Nuclear Proteins (日) (読) [継承]
14. (英) Period Circadian Proteins (日) (読) [継承]
15. (英) RNA, Messenger (日) (読) [継承]
16. (英) Rats (日) (読) [継承]
17. (英) Suprachiasmatic Nucleus (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Genes to Cells ([日本分子生物学会])
(pISSN: 1356-9597, eISSN: 1365-2443)

ISSN (任意): 1356-9597
ISSN: 1356-9597 (pISSN: 1356-9597, eISSN: 1365-2443)
Title: Genes to cells : devoted to molecular & cellular mechanisms
Title(ISO): Genes Cells
Supplier: Molecular Biology Society of Japan
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 12 [継承]
(必須): 11 [継承]
(必須): 1225 1234 [継承]
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年月日 (必須): 西暦 2007年 11月 初日 (平成 19年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2443.2007.01129.x    (→Scopusで検索) [継承]
PMID (任意): 17986006    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Clock Cell Biology Group, Institute for Biological Resource and Function, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Miyazaki Koyomi, Wakabayashi Miyuki, Sachiko Chikahisa, Hiroyoshi Sei and Norio Ishida : PER2 controls circadian periods through nuclear localization in the suprachiasmatic nucleus, Genes to Cells, Vol.12, No.11, 1225-1234, 2007.
欧文冊子 ● Miyazaki Koyomi, Wakabayashi Miyuki, Sachiko Chikahisa, Hiroyoshi Sei and Norio Ishida : PER2 controls circadian periods through nuclear localization in the suprachiasmatic nucleus, Genes to Cells, Vol.12, No.11, 1225-1234, 2007.

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