| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日)
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| ○著者 (必須): | 1. | 李 雪飛
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| 2. | (英) Azlina, Ahmad (日) (読)
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| 3. | (英) Karabasil, Ratko, Mileva (日) (読)
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| 4. | (英) Purwanti, Nunuk (日) (読)
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| 5. | 長谷川 敬展 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生理学])
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| 6. | 姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生理学])
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| 7. | 赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])
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| 8. | 細井 和雄
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| ○題名 (必須): | □ | (英) Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic agonist (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) By chorda tympani denervation (CTD, parasympathectomy), the aquaporin 5 (AQP5), but not AQP1, protein level in the rat submandibular gland (SMG) was significantly decreased, dropping to 37% of that of the contralateral gland at 4 wk. The protein levels of AQP5 and AQP1 were not significantly affected by denervation of the cervical sympathetic trunk (sympathectomy). Administration of cevimeline hydrochloride, an M3 muscarinic receptor agonist (10 mg/kg for 7 days po), but not pilocarpine (0.3 mg/kg for 7 days po), recovered the AQP5 protein level reduced by CTD and increased the AQP1 protein level above the control one. The mRNA level of AQP5 was scarcely affected by CTD and cevimeline hydrochloride administration. Administration of chloroquine (50 mg/kg for 7 days po), a denaturant of lysosomes, increased the AQP5 protein level reduced by CTD. An extract obtained from the submandibular lysosomal fraction degraded the AQP5 protein in the total membrane fraction in vitro. These results suggest the possible regulation of the AQP5 protein level in the SMG by the parasympathetic nerves/M3 muscarinic receptor agonist and imply the involvement of lysosomal enzymes, but not a transcriptional mechanism, in this regulation. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Aquaporin 1 (日) (読)
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| 3. | (英) Aquaporin 5 (日) (読)
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| 4. | (英) Chorda Tympani Nerve (日) (読)
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| 5. | (英) Gene Expression Regulation (日) (読)
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| 6. | (英) Lysosomes (日) (読)
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| 7. | (英) Male (日) (読)
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| 8. | (英) Muscarinic Agonists (日) (読)
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| 9. | (英) Parasympathectomy (日) (読)
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| 10. | (英) Pilocarpine (日) (読)
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| 11. | (英) Quinuclidines (日) (読)
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| 12. | (英) RNA, Messenger (日) (読)
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| 13. | (英) Rats (日) (読)
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| 14. | (英) Rats, Sprague-Dawley (日) (読)
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| 15. | (英) Submandibular Gland (日) (読)
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| 16. | (英) Sympathectomy (日) (読)
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| 17. | (英) Thiophenes (日) (読)
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| 18. | (英) Time Factors (日) (読)
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| ○発行所 (推奨): | □ | アメリカ生理学会
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| ○誌名 (必須): | □ | American Journal of Physiology, Gastrointestinal and Liver Physiology ([アメリカ生理学会])
(pISSN: 0193-1857, eISSN: 1522-1547)
| ○ISSN (任意): | □ | 0193-1857
ISSN: 0193-1857
(pISSN: 0193-1857, eISSN: 1522-1547) Title: American journal of physiology. Gastrointestinal and liver physiologyTitle(ISO): Am J Physiol Gastrointest Liver PhysiolPublisher: American Physiological Society (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 295
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | G112 G123
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 7月 初日 (平成 20年 7月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1152/ajpgi.00359.2007 (→Scopusで検索)
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| ○PMID (任意): | □ | 18450949 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima-shi, Tokushima 770-8504, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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