『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=177573)

EID=177573EID:177573, Map:0, LastModified:2017年12月9日(土) 19:05:46, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.尾崎 和美 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.中江 英明
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.松尾 敬志
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) CC Chemokine ligand 17 in periodontal diseases: expression in diseased tissues and production by human gingival fibroblasts  (日)    [継承]
副題 (任意):
要約 (任意): (英) It has been reported that T helper 2 (Th2) cells are related to exacerbation of periodontal disease. However, it is uncertain how the migration of Th2 cells is controlled. In this study, we examined the expression of CC chemokine ligand 17 (CCL17), which is a Th2 chemokine, in periodontal tissues. Moreover, we investigated the effects of cytokines and toll-like receptor (TLR) ligands on the production of CCL17 by human gingival fibroblasts (HGFs). We used immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) to detect CCL17 in periodontal tissues. HGFs were exposed to cytokines and TLR ligands. Expression of CCL17 was examined by RT-PCR and enzyme-linked immunosorbent assay. We used signal transduction inhibitors in some experiments. Both CCL17 and its receptor, CC chemokine receptor 4 (CCR4), were expressed in diseased periodontal tissues. A combination of tumour necrosis factor alpha (TNF-alpha) and interleukin (IL)-4/IL-13 increased CCL17 expression. Moreover, treatment of HGFs with a low dose of interferon-gamma (IFN-gamma) in combination with TNF-alpha and IL-4 or IL-13 had synergistic effects on the production of CCL17, whereas a high dose of IFN-gamma inhibited CCL17 production. Furthermore, Escherichia coli (E. coli) lipopolysaccharide (TLR4 ligand) and Pam3CSK4 (TLR2 ligand) inhibited CCL17 production by TNF-alpha + IL-4-stimulated HGFs, while CpG DNA (TLR9 ligand) enhanced TNF-alpha + IL-4 induced-CCL17 production by HGFs. Furthermore, a c-Jun NH2 terminal kinase (JNK) inhibitor, a phosphatidylinositol-3-kinase (PI3K) inhibitor and a nuclear factor kappa B (NF-kappa B) inhibitor inhibited CCL17 production by HGFs. These results suggest that the CCL17 produced by HGFs may be involved in the migration of Th2 cells into inflamed tissues, and provide evidence that CCL17 production is controlled by cytokines and TLR ligands in periodontal disease.  (日)    [継承]
キーワード (推奨): 1. (英) Chemokine CCL17 (日) (読) [継承]
2. (英) Cytokines (日) (読) [継承]
3. (英) Escherichia coli (日) (読) [継承]
4. (英) Fibroblasts (日) (読) [継承]
5. (英) Gingiva (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Interferon-gamma (日) (読) [継承]
8. (英) Interleukin-13 (日) (読) [継承]
9. (英) Interleukin-4 (日) (読) [継承]
10. (英) JNK Mitogen-Activated Protein Kinases (日) (読) [継承]
11. (英) Ligands (日) (読) [継承]
12. (英) Lipopeptides (日) (読) [継承]
13. (英) Lipopolysaccharides (日) (読) [継承]
14. (英) NF-kappa B (日) (読) [継承]
15. (英) Peptides (日) (読) [継承]
16. (英) Periodontal Diseases (日) (読) [継承]
17. (英) Phosphatidylinositol 3-Kinases (日) (読) [継承]
18. (英) Receptors, CCR4 (日) (読) [継承]
19. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
20. (英) Th2 Cells (日) (読) [継承]
21. (英) Toll-Like Receptor 2 (日) (読) [継承]
22. (英) Toll-Like Receptor 4 (日) (読) [継承]
23. (英) Toll-Like Receptor 9 (日) (読) [継承]
24. (英) Toll-Like Receptors (日) (読) [継承]
25. (英) Tumor Necrosis Factor-alpha (日) (読) [継承]
発行所 (推奨): Blackwell Publishing Ltd [継承]
誌名 (必須): Journal of Periodontal Research ([Blackwell Publishing Ltd])
(pISSN: 0022-3484, eISSN: 1600-0765)

ISSN (任意): 1600-0765
ISSN: 0022-3484 (pISSN: 0022-3484, eISSN: 1600-0765)
Title: Journal of periodontal research
Title(ISO): J Periodontal Res
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 43 [継承]
(必須): 4 [継承]
(必須): 471 477 [継承]
都市 (任意):
年月日 (必須): 西暦 2008年 8月 初日 (平成 20年 8月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1600-0765.2007.01080.x    (→Scopusで検索) [継承]
PMID (任意): 18557811    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000256921300013 [継承]
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. hosokawa@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : CC Chemokine ligand 17 in periodontal diseases: expression in diseased tissues and production by human gingival fibroblasts, Journal of Periodontal Research, Vol.43, No.4, 471-477, 2008.
欧文冊子 ● Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki, Hideaki Nakae and Takashi Matsuo : CC Chemokine ligand 17 in periodontal diseases: expression in diseased tissues and production by human gingival fibroblasts, Journal of Periodontal Research, Vol.43, No.4, 471-477, 2008.

関連情報

Number of session users = 3, LA = 1.32, Max(EID) = 372496, Max(EOID) = 996220.