『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=177236EID:177236, Map:0, LastModified:2014年11月26日(水) 10:37:08, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[田中 保], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.德村 彰
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[継承]
2. (英) Shinomiya Junya (日) (読)
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[継承]
3. (英) Kishimoto Seishi (日) (読)
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[継承]
4.田中 保 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.食料科学系.食料科学分野])
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学籍番号 (推奨):
[継承]
5.小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
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学籍番号 (推奨):
[継承]
6. (英) Sugiura Takayuki (日) (読)
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7. (英) Satouchi Kiyoshi (日) (読)
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[継承]
8. (英) Waku Keizo (日) (読)
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9.福澤 健治
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[継承]
題名 (必須): (英) Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids  (日)    [継承]
副題 (任意):
要約 (任意): (英) Lysophosphatidic acid (LPA) is a physiological agonist that is produced by lysophospholipase D, phospholipase A(1) and phospholipase A(2) in the blood of animals. It exerts diverse biological actions on a broad range of animal cells. Specific receptors for this important agonist have been characterized. In this investigation, for the first time we prepared LPAs having a highly unsaturated fatty acyl group, such as the eicosapentaenoyl or docosahexaenoyl residue, and their acetylated derivatives. Human platelets aggregated more potently in response to the highly unsaturated acyl-LPAs than to LPAs with a C(18) fatty acyl group, such as an oleoyl group, while alkyl ether-linked LPAs (alkyl-LPA) had much stronger aggregating activity. Two positional isomers of LPAs with an arachidonoyl, eicosapentaenoyl or docosahexaenoyl group had equipotent aggregatory activity as well as the positional isomers of their acetylated analogues, indicating that putative LPA receptors could not distinguish the difference between the positional isomers. We found that platelet preparations from two individuals showed no aggregatory response to alkyl-LPAs, although they contained mRNAs for known LPA receptors in the following order of expression level: endothelial differentiation gene (Edg)-4>Edg-7>Edg-2. We also obtained evidence that 2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid (ONO-RS-082), a phospholipase A(2) inhibitor, potentiated alkyl-LPA-induced platelet aggregation, but inhibited highly unsaturated acyl-LPA-induced platelet aggregation. These results indicated that human platelets express acyl-LPA-selective and alkyl-LPA-selective receptors on their plasma membrane.  (日)    [継承]
キーワード (推奨): 1. (英) Affinity Labels (日) (読) [継承]
2. (英) Aminobenzoic Acids (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Blood Platelets (日) (読) [継承]
5. (英) Cattle (日) (読) [継承]
6. (英) Cinnamates (日) (読) [継承]
7. (英) Dose-Response Relationship, Drug (日) (読) [継承]
8. (英) Fatty Acids, Unsaturated (日) (読) [継承]
9. (英) Gas Chromatography-Mass Spectrometry (日) (読) [継承]
10. (英) Glyceryl Ethers (日) (読) [継承]
11. (英) Humans (日) (読) [継承]
12. (英) Lysophospholipids (日) (読) [継承]
13.分子構造 (molecular structure) [継承]
14. (英) Nuclear Proteins (日) (読) [継承]
15. (英) Phosphodiesterase Inhibitors (日) (読) [継承]
16. (英) Platelet Aggregation (日) (読) [継承]
17. (英) Receptors, Cell Surface (日) (読) [継承]
18. (英) Receptors, G-Protein-Coupled (日) (読) [継承]
19. (英) Receptors, Lysophosphatidic Acid (日) (読) [継承]
20. (英) Serum Albumin, Bovine (日) (読) [継承]
21. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Biochemical Journal ([The Biochemical Society])
(pISSN: 0264-6021, eISSN: 1470-8728)

ISSN (任意): 0264-6021
ISSN: 0264-6021 (pISSN: 0264-6021, eISSN: 1470-8728)
Title: The Biochemical journal
Title(ISO): Biochem J
Publisher: Portland Press, Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 365 [継承]
(必須): Pt 3 [継承]
(必須): 617 628 [継承]
都市 (任意):
年月日 (必須): 西暦 2002年 8月 1日 (平成 14年 8月 1日) [継承]
URL (任意):
DOI (任意): 10.1042/BJ20020348    (→Scopusで検索) [継承]
PMID (任意): 11982483    (→Scopusで検索) [継承]
NAID (任意): 80015451613 [継承]
WOS (任意): 000177365400005 [継承]
Scopus (任意): 2-s2.0-0036683314 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78 Shomachi, Tokushima 770-8505, Japan. tokumura@ph.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC1222725  (日)    [継承]

標準的な表示

和文冊子 ● Akira Tokumura, Junya Shinomiya, Seishi Kishimoto, Tamotsu Tanaka, Kentaro Kogure, Takayuki Sugiura, Kiyoshi Satouchi, Keizo Waku and Kenji Fukuzawa : Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids, The Biochemical Journal, Vol.365, No.Pt 3, 617-628, 2002.
欧文冊子 ● Akira Tokumura, Junya Shinomiya, Seishi Kishimoto, Tamotsu Tanaka, Kentaro Kogure, Takayuki Sugiura, Kiyoshi Satouchi, Keizo Waku and Kenji Fukuzawa : Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids, The Biochemical Journal, Vol.365, No.Pt 3, 617-628, 2002.

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