| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
| [継承] |
| ○カテゴリ (推奨): | □ | 研究
| [継承] |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.創薬資源科学部門.資源分子探索学講座 (2004年4月1日〜)
| [継承] |
| ○著者 (必須): | 1. | (英) Sekiya Michiko (日) 関谷 倫子 (読) せきや みちこ
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 柏田 良樹
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | (英) Nabekura Tomohiro (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Kitagawa Shuji (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Yamagishi Takashi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | (英) Yokozawa Takako (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | (英) Ichiyanagi Takashi (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 8. | (英) Ikeshiro Yasumasa (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 9. | 高石 喜久
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Effect of Triterpenoids from the Floral Spikes of Betula platyphylla var. japonica on Glycoprotein Function (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) One of the major causes of multidrug resistance (MDR) in cancer cells is over-expression of P-glycoprotein (P-gp). We studied the effects of 20 triterpenes isolated from the floral spikes of Betula platyphylla var. japonica ( B. platyphylla) on P-gp function based on our previous finding that some of them showed MDR reversing effects. We evaluated accumulations and effluxes of rhodamine 123 as a P-gp substrate with P-gp over-expressing KB-C2 cells. Among the 20 triterpenes, compounds 3, 4, 8, 9, 13, 15, and 20 increased rhodamine 123 accumulations in KB-C2 cells, and three ( 8, 13, and 20) of them also inhibited efflux of rhodamine 123 out of cells. In addition, compounds 13 and 20 showed a weak inhibitory activity of P-gp ATPase. These results suggested that MDR reversing effects of compounds 13 and 20 are partly involved in inhibition of P-gp ATPase. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Antineoplastic Agents, Phytogenic (日) (読)
| [継承] |
| 2. | (英) Betula (日) (読)
| [継承] |
| 3. | (英) Cell Line, Tumor (日) (読)
| [継承] |
| 4. | (英) Drug Resistance, Neoplasm (日) (読)
| [継承] |
| 5. | (英) Flowering Tops (日) (読)
| [継承] |
| 6. | (英) Fluorescent Dyes (日) (読)
| [継承] |
| 7. | (英) Humans (日) (読)
| [継承] |
| 8. | (英) P-Glycoprotein (日) (読)
| [継承] |
| 9. | (英) Phytotherapy (日) (読)
| [継承] |
| 10. | (英) Plant Extracts (日) (読)
| [継承] |
| 11. | (英) Rhodamine 123 (日) (読)
| [継承] |
| 12. | (英) Triterpenes (日) (読)
| [継承] |
| ○発行所 (推奨): | □ | (英) Thieme Publishers (日) (読)
| [継承] |
| ○誌名 (必須): | □ | Planta Medica (Thieme Medical Publishers, Inc.)
(pISSN: 0032-0943, eISSN: 1439-0221)
| ○ISSN (任意): | □ | 0032-0943
ISSN: 0032-0943
(pISSN: 0032-0943, eISSN: 1439-0221) Title: Planta medicaTitle(ISO): Planta MedPublisher: Georg Thieme Verlag KG (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 73
| [継承] |
| ○号 (必須): | □ | 15
| [継承] |
| ○頁 (必須): | □ | 1558 1562
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2007年 12月 3日 (平成 19年 12月 3日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1055/s-2007-993745 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 18058609 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○Scopus (任意): |
| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan. mmsk@nupals.ac.jp (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |