『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.顎口腔再建医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1. (英) Ueki M (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Tanaka N (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Tanimoto K (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Nishio C (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Honda K (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Lin YY (日) (読)
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学籍番号 (推奨):
[継承]
7. (英) Tanne Y (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Ohkuma S (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Kamiya T (日) (読)
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学籍番号 (推奨):
[継承]
10.田中 栄二 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.口腔顎顔面矯正学])
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学籍番号 (推奨):
[継承]
11.丹根 一夫 ([広島大学])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) The effect of mechanical loading on the metabolism of growth plate chondrocytes  (日)    [継承]
副題 (任意):
要約 (任意): (英) It is well known that mechanical loading influences the endochondral bone formation essential for the growth and development of longitudinal bones. The question was, however, asked whether the effect of mechanical loading on the chondrocyte metabolism is dependent on the loading frequency. This study was aimed at evaluating the effect of tensile loadings with various frequencies on the proliferation of growth plate chondrocytes and extracellular matrix synthesis. The chondrocytes obtained from rib growth plate cartilage of 4-week-old male Wistar strain rats were cultured by day 4 and day 11 and used as proliferating and matrix-forming chondrocytes, respectively. Intermittent tensile stresses with different frequencies were applied to each stage chondrocyte. DNA syntheses were examined by measuring the incorporation of [(3)H]thymidine into the cells. Furthermore, the rates of collagen and proteoglycan syntheses were determined by measuring the incorporation of [2,3-(3)H]proline and [(35)S]sulfate into the cells, respectively. At the proliferating stage, intermittent tensions with the frequencies of 30 cycles/min and 150 cycles/min significantly (p < 0.05) upregulated the syntheses of DNA, which indicates the promotion of chondrocyte proliferation. At the matrix-forming stage, collagen, and proteoglycan syntheses also enhanced with increase of the loading frequency. In particular, the intermittent tension with the frequencies of 30 cycles/min and 150 cycles/min increased significantly (p < 0.05 or p < 0.01) both the collagen and proteoglycan syntheses. These results suggest that the proliferation and differentiation of growth plate chondrocytes are regulated by the mechanical loading and that the chondrocyte metabolism enhanced with increase of loading frequency. These may give more insight into the possible mechanism leading to endochondral bone formation.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cells, Cultured (日) (読) [継承]
3. (英) Chondrocytes (日) (読) [継承]
4. (英) Collagen (日) (読) [継承]
5. (英) Extracellular Matrix (日) (読) [継承]
6. (英) Extracellular Matrix Proteins (日) (読) [継承]
7. (英) Growth Plate (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Mechanotransduction, Cellular (日) (読) [継承]
10. (英) Proteoglycans (日) (読) [継承]
11. (英) Rats (日) (読) [継承]
12. (英) Rats, Wistar (日) (読) [継承]
13. (英) Stress, Mechanical (日) (読) [継承]
14. (英) Tensile Strength (日) (読) [継承]
15. (英) Weight-Bearing (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Annals of Biomedical Engineering (Biomedical Engineering Society (BMES).)
(pISSN: 0090-6964, eISSN: 1573-9686)

ISSN (任意): 1573-9686
ISSN: 0090-6964 (pISSN: 0090-6964, eISSN: 1573-9686)
Title: Annals of biomedical engineering
Title(ISO): Ann Biomed Eng
Supplier: Kluwer Online
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2008年 5月 末日 (平成 20年 5月 末日) [継承]
URL (任意):
DOI (任意): 10.1007/s10439-008-9462-7    (→Scopusで検索) [継承]
PMID (任意): 18278554    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Hiroshima, 734-8553, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● M Ueki, N Tanaka, K Tanimoto, C Nishio, K Honda, YY Lin, Y Tanne, S Ohkuma, T Kamiya, Eiji Tanaka and Kazuo Tanne : The effect of mechanical loading on the metabolism of growth plate chondrocytes, Annals of Biomedical Engineering, Vol.36, No.5, 793-800, 2008.
欧文冊子 ● M Ueki, N Tanaka, K Tanimoto, C Nishio, K Honda, YY Lin, Y Tanne, S Ohkuma, T Kamiya, Eiji Tanaka and Kazuo Tanne : The effect of mechanical loading on the metabolism of growth plate chondrocytes, Annals of Biomedical Engineering, Vol.36, No.5, 793-800, 2008.

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