『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Sekine Shinichi (日) (読)
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[継承]
2.片岡 宏介 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健福祉学])
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[継承]
3. (英) Fukuyama Yoshiko (日) (読)
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[継承]
4. (英) Adachi Yasuo (日) (読)
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[継承]
5. (英) Davydova Julia (日) (読)
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[継承]
6. (英) Yamamoto Masato (日) (読)
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[継承]
7. (英) Kobayashi Ryoki (日) (読)
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学籍番号 (推奨):
[継承]
8. (英) Fujihashi Keiko (日) (読)
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[継承]
9. (英) Suzuki Hideaki (日) (読)
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[継承]
10. (英) Curiel David (日) (読)
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[継承]
11. (英) Shizukuishi Satoshi (日) (読)
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[継承]
12. (英) McGhee Jerry (日) (読)
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[継承]
13. (英) Fujihashi Kohtaro (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature NALT dendritic cell migration.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Previously, we showed that nasal administration of a naked cDNA plasmid expressing Flt3 ligand (FL) cDNA (pFL) enhanced CD4(+) Th2-type, cytokine-mediated mucosal immunity and increased lymphoid-type dendritic cell (DC) numbers. In this study, we investigated whether targeting nasopharyngeal-associated lymphoreticular tissue (NALT) DCs by a different delivery mode of FL, i.e., an adenovirus (Ad) serotype 5 vector expressing FL (Ad-FL), would provide Ag-specific humoral and cell-mediated mucosal immunity. Nasal immunization of mice with OVA plus Ad-FL as mucosal adjuvant elicited high levels of OVA-specific Ab responses in external secretions and plasma as well as significant levels of OVA-specific CD4(+) T cell proliferative responses and OVA-induced IFN-gamma and IL-4 production in NALT, cervical lymph nodes, and spleen. We also observed higher levels of OVA-specific CTL responses in the spleen and cervical lymph nodes of mice given nasal OVA plus Ad-FL than in mice receiving OVA plus control Ad. Notably, the number of CD11b(+)CD11c(+) DCs expressing high levels of costimulatory molecules was preferentially increased. These DCs migrated from the NALT to mucosal effector lymphoid tissues. Taken together, these results suggest that the use of Ad-FL as a nasal adjuvant preferentially induces mature-type NALT CD11b(+)CD11c(+) DCs that migrate to effector sites for subsequent CD4(+) Th1- and Th2-type cytokine-mediated, Ag-specific Ab and CTL responses.  (日)    [継承]
キーワード (推奨): 1. (英) Adenoviridae (日) (読) [継承]
2. (英) Adjuvants, Immunologic (日) (読) [継承]
3. (英) Administration, Intranasal (日) (読) [継承]
4. (英) Animals (日) (読) [継承]
5. (英) Cell Differentiation (日) (読) [継承]
6. (英) Cell Line (日) (読) [継承]
7. (英) Cell Line, Tumor (日) (読) [継承]
8. (英) Cell Movement (日) (読) [継承]
9. (英) Dendritic Cells (日) (読) [継承]
10. (英) Female (日) (読) [継承]
11. (英) Genetic Vectors (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13. (英) Immunity, Mucosal (日) (読) [継承]
14. (英) Lymphoid Tissue (日) (読) [継承]
15. (英) Membrane Proteins (日) (読) [継承]
16. (英) Mice (日) (読) [継承]
17. (英) Mice, Inbred C57BL (日) (読) [継承]
18. (英) Mononuclear Phagocyte System (日) (読) [継承]
19. (英) Nasopharynx (日) (読) [継承]
20. (英) fms-Like Tyrosine Kinase 3 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 8126 8134 [継承]
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年月日 (必須): 西暦 2008年 6月 15日 (平成 20年 6月 15日) [継承]
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PMID (任意): 18523277    (→Scopusで検索) [継承]
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WOS (任意): 000257404600038 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pediatric Dentistry and Microbiology, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
5.(英) OtherID: NIHMS48639  (日)    [継承]
6.(英) OtherID: PMC2587249  (日)    [継承]

標準的な表示

和文冊子 ● Shinichi Sekine, Kosuke Kataoka, Yoshiko Fukuyama, Yasuo Adachi, Julia Davydova, Masato Yamamoto, Ryoki Kobayashi, Keiko Fujihashi, Hideaki Suzuki, David Curiel, Satoshi Shizukuishi, Jerry McGhee and Kohtaro Fujihashi : A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature NALT dendritic cell migration., The Journal of Immunology, Vol.180, No.12, 8126-8134, 2008.
欧文冊子 ● Shinichi Sekine, Kosuke Kataoka, Yoshiko Fukuyama, Yasuo Adachi, Julia Davydova, Masato Yamamoto, Ryoki Kobayashi, Keiko Fujihashi, Hideaki Suzuki, David Curiel, Satoshi Shizukuishi, Jerry McGhee and Kohtaro Fujihashi : A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature NALT dendritic cell migration., The Journal of Immunology, Vol.180, No.12, 8126-8134, 2008.

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