『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=175484)

EID=175484EID:175484, Map:0, LastModified:2013年11月27日(水) 15:29:21, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[山﨑 尚志], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.疾患プロテオゲノム研究センター (2008年4月1日〜2016年3月31日/->組織[徳島大学.先端酵素学研究所.プロテオゲノム研究領域]) [継承]
著者 (必須): 1. (英) Watanabe Masahiro (日) (読)
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学籍番号 (推奨):
[継承]
2.山本 武範
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[継承]
3. (英) Mori Chihiro (日) (読)
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[継承]
4.岡田 直人
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[継承]
5.山﨑 尚志 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.薬物治療学])
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[継承]
6. (英) Kajimoto Kazuaki (日) (読)
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[継承]
7.片岡 正俊
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学籍番号 (推奨):
[継承]
8.篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Cold-induced changes in gene expression in brown adipose tissue: implications for the activation of thermogenesis.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Brown adipose tissue (BAT) is the site of heat production (thermogenesis). This unique function is performed by uncoupling protein 1 (UCP1) specifically expressed in mitochondria of BAT. UCP1 dissipates the driving force of ATP synthesis, and thus causes heat production followed by energy expenditure. The thermogenic function of BAT has the role of maintaining body temperature under cold conditions. When animals are exposed to cold, the expression of UCP1 gene is increased to activate thermogenesis. To date, functional analysis of BAT has been focused on UCP1, because it plays an indispensable role in thermogenesis. However, the gene expression of not only UCP1 but also that of other genes in BAT is expected to be regulated to achieve effective thermogenesis. Our previous investigations showed increased expression of genes that encode several energy metabolic enzymes in the BAT of rats kept in the cold. These changes in gene expression imply that the enhancement of energy metabolism is needed to activate thermogenesis. Furthermore, various reports from studies focused on genes whose expression is changed in response to cold stimulation have provided new insights into the function of BAT. In this review, to understand the thermogenic function of BAT systematically, we have provided an overview of previous findings on changes in the expression of genes thought to be related to the activation of thermogenesis in BAT.  (日)    [継承]
キーワード (推奨): 1.褐色脂肪組織 (brown adipose tissue) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Cold Temperature (日) (読) [継承]
4.遺伝子発現 (gene expression) [継承]
5. (英) Humans (日) (読) [継承]
6. (英) Thermogenesis (日) (読) [継承]
発行所 (推奨): 日本薬学会 [継承]
誌名 (必須): Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)

ISSN (任意): 0918-6158
ISSN: 0918-6158 (pISSN: 0918-6158, eISSN: 1347-5215)
Title: Biological & pharmaceutical bulletin
Title(ISO): Biol Pharm Bull
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 31 [継承]
(必須): 5 [継承]
(必須): 775 784 [継承]
都市 (任意): 東京 (Tokyo/[日本国]) [継承]
年月日 (必須): 西暦 2008年 5月 初日 (平成 20年 5月 初日) [継承]
URL (任意):
DOI (任意): 10.1248/bpb.31.775    (→Scopusで検索) [継承]
PMID (任意): 18451493    (→Scopusで検索) [継承]
NAID (任意): 110006663927 [継承]
WOS (任意): 000256182500001 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Institute for Genome Research, University of Tokushima, Kuramotocho-3, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) NumberOfReferences: 114  (日)    [継承]

標準的な表示

和文冊子 ● Masahiro Watanabe, Takenori Yamamoto, Chihiro Mori, Naoto Okada, Naoshi Yamazaki, Kazuaki Kajimoto, Masatoshi Kataoka and Yasuo Shinohara : Cold-induced changes in gene expression in brown adipose tissue: implications for the activation of thermogenesis., Biological & Pharmaceutical Bulletin, Vol.31, No.5, 775-784, May 2008.
欧文冊子 ● Masahiro Watanabe, Takenori Yamamoto, Chihiro Mori, Naoto Okada, Naoshi Yamazaki, Kazuaki Kajimoto, Masatoshi Kataoka and Yasuo Shinohara : Cold-induced changes in gene expression in brown adipose tissue: implications for the activation of thermogenesis., Biological & Pharmaceutical Bulletin, Vol.31, No.5, 775-784, May 2008.

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