『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1.玉井 伸岳 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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2. (英) Uemura Maiko (日) (読)
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3.後藤 優樹 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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4.松木 均 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意): (英)   (日) 考察   [継承]
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5.金品 昌志
役割 (任意): (英)   (日) 計画,解析,考察   [継承]
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題名 (必須): (英) Lateral phase separation in cholesterol/diheptadecanoylphosphatidylcholine binary bilayer membrane  (日)    [継承]
副題 (任意):
要約 (任意): (英) We investigated the phase behavior of cholesterol/diheptadecanoylphosphatidylcholine (C17:0-PC) binary bilayer membrane as a function of the cholesterol composition (X(ch)) by fluorescence spectroscopy using 6-propionyl-2-(dimethylamino)naphthalene (Prodan) and differential scanning calorimetry (DSC). The fluorescence spectra showed that the wavelength at the maximum intensity (lambda(max)) changed depending on the bilayer state: ca. 440 nm for the lamellar gel (L'(beta) or L(beta)) and the liquid ordered (L(o)) phases and ca. 490 nm for the liquid-crystalline (L(alpha)) phase. The transition temperatures were determined from the temperature dependence of lambda(max) and endothermic peaks of the DSC thermograms. Both measurements showed that the pre- and main transition disappear around X(ch)=0.05 and 0.30, respectively. The constructed temperature-X(ch) phase diagram resembled a typical phase diagram for a eutectic binary mixture containing a peritectic point. The presence of a peritectic point at X(ch)=0.15 suggested that a complex of cholesterol and C17:0-PC is stoichiometrically formed in the gel phase. Consideration based on the hexagonal lattice model revealed that the compositions of 0.05 and 0.15 correspond to the bilayer states where cholesterol molecules are regularly distributed in different ways. The former is nearly equal to the composition for the membrane occupied entirely with Units (1:18), composed of a cholesterol and 18 surrounding C17:0-PC molecules within the next-next nearest neighbor sites. The latter is represented by a Unit (1:6), including a cholesterol and 6 surrounding C17:0-PC molecules. Further, the disappearance of the main transition at X(ch)=0.30 indicates that the pure L(o) phase can exist in X(ch)>0.30. The eutectic behavior observed in the phase diagram was explainable in terms of phase separation between two different types of regions with different types of regular distributions of cholesterol.  (日)    [継承]
キーワード (推奨): 1. (英) Calorimetry, Differential Scanning (日) (読) [継承]
2. (英) Cholesterol (日) (読) [継承]
3. (英) Crystallization (日) (読) [継承]
4. (英) Lipid Bilayers (日) (読) [継承]
5. (英) Phosphatidylcholines (日) (読) [継承]
6. (英) Spectrometry, Fluorescence (日) (読) [継承]
発行所 (推奨): Elsevier Science [継承]
誌名 (必須): Colloids and Surfaces B:Biointerfaces ([Elsevier])
(pISSN: 0927-7765, eISSN: 1873-4367)

ISSN (任意): 0927-7765
ISSN: 0927-7765 (pISSN: 0927-7765, eISSN: 1873-4367)
Title: Colloids and surfaces. B, Biointerfaces
Title(ISO): Colloids Surf B Biointerfaces
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 213 219 [継承]
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年月日 (必須): 西暦 2008年 9月 1日 (平成 20年 9月 1日) [継承]
URL (任意):
DOI (任意): 10.1016/j.colsurfb.2008.04.004    (→Scopusで検索) [継承]
PMID (任意): 18502622    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Life System, Institute of Technology and Science, The University of Tokushima, 2-1 Minamijosanjima-cho, Tokushima 770-8506, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Nobutake Tamai, Maiko Uemura, Masaki GOTO, Hitoshi Matsuki and Shoji Kaneshina : Lateral phase separation in cholesterol/diheptadecanoylphosphatidylcholine binary bilayer membrane, Colloids and Surfaces B:Biointerfaces, Vol.65, No.2, 213-219, 2008.
欧文冊子 ● Nobutake Tamai, Maiko Uemura, Masaki GOTO, Hitoshi Matsuki and Shoji Kaneshina : Lateral phase separation in cholesterol/diheptadecanoylphosphatidylcholine binary bilayer membrane, Colloids and Surfaces B:Biointerfaces, Vol.65, No.2, 213-219, 2008.

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