| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日)
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| 2. | 徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座 (2007年4月1日〜)
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| ○著者 (必須): | 1. | 岡村 裕彦
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| 2. | 吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健支援学]/[徳島大学.歯学部.口腔保健学科.口腔保健支援学講座])
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| 3. | (英) Amorim Rabelo Bruna (日) (読)
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| 4. | 羽地 達次
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| ○題名 (必須): | □ | (英) Histone H1.2 is translocated to mitochondria and associates with Bak in bleomycin-induced apoptotic cells (日)
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| ○要約 (任意): | □ | (英) Bleomycin induces single- and double-stranded breaks in DNA, with consequent mitochondrial membrane aberrations that lead to the apoptotic cell death. It is poorly understood how DNA damage-inducing apoptotic signals are transmitted to mitochondria, from which apoptotic factors are released into the cytoplasm. Here, we investigated the localization of histone H1.2 in the bleomycin-treated human squamous carcinoma SCCTF cells. The presence of DNA double-strand breaks in the bleomycin-treated cells was examined by Western analysis using antibody against phosphorylated histone H2AX (gamma-H2AX). Incubation of SCCTF cells for 48 h with 10 microM bleomycin induced apoptosis, as determined by cleavage of lamin B1 to 28 kDa fragment and DNA ladder formation. The mitochondrial permeabilization causing apoptotic feature was also detected with MitoCapture in the bleomycin-treated cells. Histone H1.2 was translocated from the nucleus to the mitochondria after treatment with bleomycin and co-localized with Bak in mitochondria. Our present results suggest that histone H1.2 plays an important role in transmitting apoptotic signals from the nucleus to the mitochondria following double-stranded breaks of DNA by bleomycin. (日)
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| ○キーワード (推奨): | 1. | (英) Antibiotics, Antineoplastic (日) (読)
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| 2. | (英) Apoptosis (日) (読)
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| 3. | (英) Bleomycin (日) (読)
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| 4. | (英) Cell Line, Tumor (日) (読)
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| 5. | (英) Cell Membrane Permeability (日) (読)
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| 6. | (英) DNA Breaks, Double-Stranded (日) (読)
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| 7. | (英) DNA Breaks, Single-Stranded (日) (読)
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| 8. | (英) DNA Fragmentation (日) (読)
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| 9. | (英) Histones (日) (読)
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| 10. | (英) Humans (日) (読)
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| 11. | (英) Laminin (日) (読)
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| 12. | (英) Mitochondria (日) (読)
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| 13. | (英) Mitochondrial Membranes (日) (読)
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| 14. | (英) Protein Transport (日) (読)
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| 15. | (英) Signal Transduction (日) (読)
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| 16. | (英) bcl-2 Homologous Antagonist-Killer Protein (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Cellular Biochemistry ([Wiley-Liss, Inc.])
(pISSN: 0730-2312, eISSN: 1097-4644)
| ○ISSN (任意): | □ | 1097-4644
ISSN: 0730-2312
(pISSN: 0730-2312, eISSN: 1097-4644) Title: Journal of cellular biochemistryTitle(ISO): J Cell BiochemPublisher: Wiley (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 103
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 1488 1496
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2008年 4月 1日 (平成 20年 4月 1日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1002/jcb.21537 (→Scopusで検索)
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| ○PMID (任意): | □ | 17879944 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Histology and Oral Histology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima 770-8504, Japan. okamura@dent.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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