『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=172764EID:172764, Map:0, LastModified:2012年8月31日(金) 18:30:13, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松本 満], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hamazaki Yoko (日) (読)
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2. (英) Fujita Harumi (日) (読)
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3. (英) Kobayashi Takashi (日) (読)
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4. (英) Choi Yongwon (日) (読)
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5. (英) Scott S Hamish (日) (読)
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6.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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7. (英) Minato Nagahiro (日) (読)
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題名 (必須): (英) Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin  (日)    [継承]
副題 (任意):
要約 (任意): (英) The autoimmune regulator Aire is expressed in a small proportion of medullary thymic epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin and development of Aire(+) mTECs, however, are not well understood. Here we demonstrate that the tight-junction components claudin-3 and claudin-4 (Cld3,4) were 'preferentially' expressed in Aire(+) mTECs. In early ontogeny, Cld3,4(hi) TECs derived from the most apical layer of the stratified thymic anlage first expressed known mTEC markers such as UEA-1 ligand and MTS10. We provide evidence that such Cld3,4(hi) UEA-1(+) TECs represented the initial progenitors specified for Aire(+) mTECs, whose development crucially required NF-kappaB-inducing kinase and the adaptor molecule TRAF6. Our results suggest that Aire(+) mTECs represent terminally differentiated cells in a unique lineage arising during thymic organogenesis.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Differentiation (日) (読) [継承]
3. (英) Cell Lineage (日) (読) [継承]
4. (英) Embryo, Mammalian (日) (読) [継承]
5. (英) Epithelial Cells (日) (読) [継承]
6. (英) Flow Cytometry (日) (読) [継承]
7. (英) Histocompatibility Antigens Class II (日) (読) [継承]
8. (英) Immunohistochemistry (日) (読) [継承]
9. (英) Membrane Proteins (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
12. (英) Thymus Gland (日) (読) [継承]
13. (英) Tight Junctions (日) (読) [継承]
14. (英) Transcription Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Nature Immunology ([Nature Publishing Group])
(pISSN: 1529-2908, eISSN: 1529-2916)

ISSN (任意): 1529-2908
ISSN: 1529-2908 (pISSN: 1529-2908, eISSN: 1529-2916)
Title: Nature immunology
Title(ISO): Nat Immunol
Publisher: Nature Publishing Group
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2007年 2月 4日 (平成 19年 2月 4日) [継承]
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DOI (任意): 10.1038/ni1438    (→Scopusで検索) [継承]
PMID (任意): 17277780    (→Scopusで検索) [継承]
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評価値 (任意): **** [制限]
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備考 (任意): 1.(英) Article.Affiliation: Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Yoko Hamazaki, Harumi Fujita, Takashi Kobayashi, Yongwon Choi, Hamish S Scott, Mitsuru Matsumoto and Nagahiro Minato : Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin, Nature Immunology, Vol.8, No.3, 304-311, 2007.
欧文冊子 ● Yoko Hamazaki, Harumi Fujita, Takashi Kobayashi, Yongwon Choi, Hamish S Scott, Mitsuru Matsumoto and Nagahiro Minato : Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin, Nature Immunology, Vol.8, No.3, 304-311, 2007.

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