『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Qin Junwen (日) (読)
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[継承]
2. (英) Konno Hiroyasu (日) (読)
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[継承]
3. (英) Ohshima Daisuke (日) (読)
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[継承]
4. (英) Yanai Hiromi (日) (読)
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[継承]
5. (英) Motegi Hidehiko (日) (読)
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6. (英) Shimo Yusuke (日) (読)
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[継承]
7. (英) Hirota Fumiko (日) (読)
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8.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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9. (英) Takaki Satoshi (日) (読)
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[継承]
10. (英) Inoue Jun-ichiro (日) (読)
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11. (英) Akiyama Taishin (日) (読)
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[継承]
題名 (必須): (英) Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs  (日)    [継承]
副題 (任意):
要約 (任意): (英) Signal transduction pathways regulating NF-kappaB activation essential for microenvironment formation in secondary lymphoid organs remain to be determined. We investigated the effect of a deficiency of TNFR-associated factor 6 (TRAF6), which activates the classical NF-kappaB pathway, in splenic microenvironment formation. Two-week-old TRAF6-deficient mice showed severe defects in B cell follicle and marginal zone formation, similar to mutant mice defective in lymphotoxin (Lt) beta receptor (LtbetaR) signal induction of nonclassical NF-kappaB activation. However, analysis revealed a TRAF6 role in architecture formation distinct from its role in the early neonatal Lt signaling pathway. LtbetaR signal was essential for primary B cell cluster formation with initial differentiation of follicular dendritic cells (FDCs) in neonatal mice. In contrast, TRAF6 was dispensable for progression to this stage but was required for converting B cell clusters to B cell follicles and maintaining FDCs through to later stages. Fetal liver transfer experiments suggested that TRAF6 in radiation-resistant cells is responsible for follicle formation. Despite FDC-specific surface marker expression, FDCs in neonatal TRAF6-deficient mice had lost the capability to express CXCL13. These data suggest that developmentally regulated activation of TRAF6 in FDCs is required for inducing CXCL13 expression to maintain B cell follicles.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, Differentiation (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Chemokine CXCL13 (日) (読) [継承]
5. (英) Dendritic Cells, Follicular (日) (読) [継承]
6. (英) Liver (日) (読) [継承]
7. (英) Lymphotoxin beta Receptor (日) (読) [継承]
8. (英) Lymphotoxin-beta (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred BALB C (日) (読) [継承]
11. (英) Mice, Knockout (日) (読) [継承]
12. (英) Mice, Mutant Strains (日) (読) [継承]
13. (英) NF-kappa B (日) (読) [継承]
14. (英) Signal Transduction (日) (読) [継承]
15. (英) Spleen (日) (読) [継承]
16. (英) TNF Receptor-Associated Factor 6 (日) (読) [継承]
発行所 (推奨):
誌名 (必須): The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)

ISSN (任意): 0022-1767
ISSN: 0022-1767 (pISSN: 0022-1767, eISSN: 1550-6606)
Title: Journal of immunology (Baltimore, Md. : 1950)
Title(ISO): J Immunol
Publisher: American Association of Immunologists
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 179 [継承]
(必須): 10 [継承]
(必須): 6799 6807 [継承]
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年月日 (必須): 西暦 2007年 11月 15日 (平成 19年 11月 15日) [継承]
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DOI (任意):
PMID (任意): 17982070    (→Scopusで検索) [継承]
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WOS (任意): 000250792700048 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Junwen Qin, Hiroyasu Konno, Daisuke Ohshima, Hiromi Yanai, Hidehiko Motegi, Yusuke Shimo, Fumiko Hirota, Mitsuru Matsumoto, Satoshi Takaki, Jun-ichiro Inoue and Taishin Akiyama : Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs, The Journal of Immunology, Vol.179, No.10, 6799-6807, 2007.
欧文冊子 ● Junwen Qin, Hiroyasu Konno, Daisuke Ohshima, Hiromi Yanai, Hidehiko Motegi, Yusuke Shimo, Fumiko Hirota, Mitsuru Matsumoto, Satoshi Takaki, Jun-ichiro Inoue and Taishin Akiyama : Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs, The Journal of Immunology, Vol.179, No.10, 6799-6807, 2007.

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