『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=172545)

EID=172545EID:172545, Map:0, LastModified:2015年3月2日(月) 19:51:07, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[松本 満], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
役割 (任意):
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Autoimmune regulator functions in autoimmunity control.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Mutation of the autoimmune regulator (AIRE) gene is responsible for the development of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), an organ-specific autoimmune disease with monogenic autosomal recessive inheritance. AIRE is strongly expressed in thymic epithelial cells (TECs), and its structural features suggest that it probably acts as a transcriptional regulator. The role of Aire in the elimination of autoreactive T cells (i.e., negative selection) has been well demonstrated with the use of transgenic mouse models, although how Aire regulates this process in TECs has yet to be determined. Aire also regulates other features of autoimmunity, such as target-organ specificity of autoimmune destruction, suggesting that an understanding of the relationship between AIRE gene malfunction and the breakdown of self-tolerance promises to help unravel the pathogenesis of not only APECED but also other types of autoimmune diseases. Owing to this unique tolerogenic function of Aire, the cellular origin and developmental process of Aire-expressing TECs is now becoming an interesting field for intense research.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): Expert Review of Clinical Immunology (Informa Healthcare)
(pISSN: 1744-666X, eISSN: 1744-8409)

ISSN (任意): 1744-8409
ISSN: 1744-666X (pISSN: 1744-666X, eISSN: 1744-8409)
Title: Expert review of clinical immunology
Title(ISO): Expert Rev Clin Immunol
Publisher: Taylor & Francis
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 3 [継承]
(必須): 6 [継承]
(必須): 891 900 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 11月 初日 (平成 19年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1586/1744666X.3.6.891    (→Scopusで検索) [継承]
PMID (任意): 20477138    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-36249007517 [継承]
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備考 (任意): 1.(英) Article.ELocationID: 10.1586/1744666X.3.6.891  (日)    [継承]
2.(英) Article.Affiliation: University of Tokushima, Division of Molecular Immunology, Institute for Enzyme Research, Tokushima 770-8503, Japan. mitsuru@ier.tokushima-u.ac.jp  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Mitsuru Matsumoto : Autoimmune regulator functions in autoimmunity control., Expert Review of Clinical Immunology, Vol.3, No.6, 891-900, Nov. 2007.
欧文冊子 ● Mitsuru Matsumoto : Autoimmune regulator functions in autoimmunity control., Expert Review of Clinical Immunology, Vol.3, No.6, 891-900, Nov. 2007.

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