『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.総合科学部.自然システム学科.物質科学講座 (〜2009年3月31日) [継承]
著者 (必須): 1.山本 裕史
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2. (英) Watanabe Mikako (日) (読)
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3. (英) Hirata Yoshiko (日) (読)
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4. (英) Nakamura Yuki (日) (読)
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5. (英) Nakamura Yudai (日) (読)
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6. (英) Kitani Chise (日) (読)
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7.関澤 純
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8. (英) Uchida Masaya (日) (読)
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9. (英) Nakamura Hiroshi (日) (読)
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10. (英) Kagami Yoshihiro (日) (読)
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11. (英) Koshio Masaaki (日) (読)
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12. (英) Hirai Narisato (日) (読)
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13. (英) Tatarazako Norihisa (日) (読)
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題名 (必須): (英) Preliminary Ecological Risk Assessment for Butylparaben and Benzylparaben  (日)    [継承]
副題 (任意): (英) 1. Removal Efficiency in Wastewater Treatment, Acute/Chronic Toxicity for Aquatic Organisms, and Effects on Medaka Gene Expression  (日)    [継承]
要約 (任意): (英) Butylparaben and benzylparaben, used as preservatives mainly in cosmetic products, have recently been found to be weakly estrogenic. Batch activated-sludge treatment and batch chlorination were carried out to roughly determine the removal efficiency of a wastewater treatment plant. Combining the removal efficiency with the estimated annual consumption and the unaltered excretion ratio, the maximum predicted environmental concentration (PEC) was estimated. Conventional acute/chronic toxicity tests were conducted using Japanese medaka (Oryzias latipes), daphnia (Daphnia magna), and green algae (Pseudokirchneriella subcapitata) for n-butylparaben, i-butylparaben, and benzylparaben. Medaka vitellogenin assays were also conducted for the three compounds and DNA microarray analysis was carried out to examine the effects of benzylparaben on gene expression. The plasma vitellogenin concentration of male medaka increased for concentrations of 200, 100, and 100 microg L(-1) n-butylparaben, i-butylparaben, and benzylparaben for 14 days, respectively, while the expression levels of genes encoding proteins such as p53, cytochrome P450 3A40, and choriogenin-L increased for concentrations higher than 4 microg L(-1) of benzylparaben. Furthermore, the predicted no-effect concentration (PNEC) was calculated using the lethal or effect concentration 50 (LC50 or EC50) values and no-effect concentrations (NOECs) obtained in the toxicity tests for these compounds. The maximum concentrations found in the aquatic environment or sewage effluent (MEC eff) were used to carry out preliminary environmental risk assessment. The calculated MEC/PNEC ratio suggests the necessity of further study such as a more detailed large-scale monitoring and chronic toxicity tests including reproduction inhibition and endocrine disruption.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.生態学 (ecology) [継承]
3.遺伝子発現 (gene expression) [継承]
4. (英) Industrial Waste (日) (読) [継承]
5. (英) No-Observed-Adverse-Effect Level (日) (読) [継承]
6. (英) Oligonucleotide Array Sequence Analysis (日) (読) [継承]
7. (英) Oryzias (日) (読) [継承]
8. (英) Parabens (日) (読) [継承]
9. (英) Risk Assessment (日) (読) [継承]
10. (英) Sewage (日) (読) [継承]
11. (英) Waste Management (日) (読) [継承]
12. (英) Water Pollutants, Chemical (日) (読) [継承]
発行所 (推奨): (英) MYU K. K. (日) (読) [継承]
誌名 (必須): Environmental Sciences (Japan Society of Endocrine Disruptors Research)
(pISSN: 0915-955X)

ISSN (任意): 0915-955X
ISSN: 0915-955X (pISSN: 0915-955X)
Title: Environmental sciences : an international journal of environmental physiology and toxicology
Title(ISO): Environ Sci
Publisher: M Y U Scientific Publishing Division
 (NLM Catalog  (Scopus (Scopus information is found. [need login])
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(必須): 14 [継承]
(必須): Supplement [継承]
(必須): 73 87 [継承]
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年月日 (必須): 西暦 2007年 12月 初日 (平成 19年 12月 初日) [継承]
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PMID (任意): 18382416    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-50649122166 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Physical, Chemical, Geological and Environmental Sciences, Faculty of Integrated Arts and Sciences, The University of Tokushima, 1-1 Minamijosanjima-cho, Tokushima, Japan. hiroshi@ias.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hiroshi Yamamoto, Mikako Watanabe, Yoshiko Hirata, Yuki Nakamura, Yudai Nakamura, Chise Kitani, Jun Sekizawa, Masaya Uchida, Hiroshi Nakamura, Yoshihiro Kagami, Masaaki Koshio, Narisato Hirai and Norihisa Tatarazako : Preliminary Ecological Risk Assessment for Butylparaben and Benzylparaben, --- 1. Removal Efficiency in Wastewater Treatment, Acute/Chronic Toxicity for Aquatic Organisms, and Effects on Medaka Gene Expression ---, Environmental Sciences, Vol.14, No.Supplement, 73-87, 2007.
欧文冊子 ● Hiroshi Yamamoto, Mikako Watanabe, Yoshiko Hirata, Yuki Nakamura, Yudai Nakamura, Chise Kitani, Jun Sekizawa, Masaya Uchida, Hiroshi Nakamura, Yoshihiro Kagami, Masaaki Koshio, Narisato Hirai and Norihisa Tatarazako : Preliminary Ecological Risk Assessment for Butylparaben and Benzylparaben, --- 1. Removal Efficiency in Wastewater Treatment, Acute/Chronic Toxicity for Aquatic Organisms, and Effects on Medaka Gene Expression ---, Environmental Sciences, Vol.14, No.Supplement, 73-87, 2007.

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