『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=172170EID:172170, Map:0, LastModified:2018年2月8日(木) 14:03:20, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[吉田 賀弥], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日) [継承]
2.徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座 (2007年4月1日〜) [継承]
著者 (必須): 1.岡村 裕彦
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2.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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3. (英) Sasaki Eiko (日) (読)
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4. (英) Qiu Lihong (日) (読)
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5. (英) Amorim Rabelo Bruna (日) (読)
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6.森本 景之
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7.羽地 達次
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題名 (必須): (英) Expression of PTEN and Akt phosphorylation in Lippopolysacccharide-treated NIH3T3 cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) PTEN is a tumor suppressor gene encoding a phosphatase, and it negatively regulates cell survival mediated by the phosphoinositol 3-kinase (PI3-Kinase)-Akt pathway. To elucidate PTEN expression and its effect on the PI3-kinase-Akt pathway in fibroblasts and macrophages, we investigated the expression of PTEN and the phosphorylation status of Akt in NIH3T3 and RAW264.7 cells treated with LPS. Phosphorylation of Akt was induced by LPS treatment in a dose-dependent manner in RAW264.7 cells, but not in NIH3T3 cells. LPS induced the expression of PTEN in a dose and time-dependent manner in NIH3T3 cells (0-1 microg/ml, 0-6h). However, LPS did not stimulate PTEN expression in RAW264.7 cells. These data indicate the existence of diverse mechanisms for PTEN expression and Akt activation in fibroblasts and macrophages. RNA interference using double-stranded RNA specific for the PTEN gene reduced both mRNA and protein levels of PTEN in NIH3T3 cells treated or not with LPS. The phosphorylation status of Akt in NIH3T3 cells stimulated with LPS did not change when the PTEN expression had been inhibited by RNA interference. The present results suggest that the up-regulation of PTEN expression by LPS is not involved in the activation of Akt in NIH3T3 cells. PTEN expression might be involved in the diverse inflammatory responses to LPS in fibroblasts and macrophages.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Fibroblasts (日) (読) [継承]
3. (英) Gene Expression Regulation, Enzymologic (日) (読) [継承]
4. (英) Insulin (日) (読) [継承]
5. (英) Lipopolysaccharides (日) (読) [継承]
6. (英) Macrophages (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) NIH 3T3 Cells (日) (読) [継承]
9. (英) PTEN Phosphohydrolase (日) (読) [継承]
10. (英) Phosphorylation (日) (読) [継承]
11. (英) Proto-Oncogene Proteins c-akt (日) (読) [継承]
12. (英) RNA, Small Interfering (日) (読) [継承]
13. (英) Signal Transduction (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cell Biology International (International Federation for Cell Biology)
(pISSN: 1065-6995, eISSN: 1095-8355)

ISSN (任意): 1065-6995
ISSN: 1065-6995 (pISSN: 1065-6995, eISSN: 1095-8355)
Title: Cell biology international
Title(ISO): Cell Biol Int
Supplier: International Federation for Cell Biology
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2007年 9月 23日 (平成 19年 9月 23日) [継承]
URL (任意):
DOI (任意): 10.1016/j.cellbi.2006.09.014    (→Scopusで検索) [継承]
PMID (任意): 17081778    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Histology and Oral Histology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8504, Japan. okamura@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirohiko Okamura, Kaya Yoshida, Eiko Sasaki, Lihong Qiu, Bruna Rabelo Amorim, Hiroyuki Morimoto and Tatsuji Haneji : Expression of PTEN and Akt phosphorylation in Lippopolysacccharide-treated NIH3T3 cells, Cell Biology International, Vol.31, No.2, 119-125, 2007.
欧文冊子 ● Hirohiko Okamura, Kaya Yoshida, Eiko Sasaki, Lihong Qiu, Bruna Rabelo Amorim, Hiroyuki Morimoto and Tatsuji Haneji : Expression of PTEN and Akt phosphorylation in Lippopolysacccharide-treated NIH3T3 cells, Cell Biology International, Vol.31, No.2, 119-125, 2007.

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