『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=172169EID:172169, Map:0, LastModified:2018年2月8日(木) 14:03:13, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[吉田 賀弥], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日) [継承]
2.徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座 (2007年4月1日〜) [継承]
3.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門 (2004年4月1日〜) [継承]
著者 (必須): 1.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
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[継承]
2. (英) Shinohara Hiroyuki (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Suryono (日) (読)
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[継承]
4.羽地 達次
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[継承]
5.永田 俊彦
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[継承]
題名 (必須): (英) Arachidonic acid inhibits osteoblast differentiation through cytosolic phospholipase A2-dependent pathway.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Arachidonic acid, a precursor of prostaglandins (PGs), is released by phospholipase A2 (PLA2) and plays an important role in biological reactions. We examined the roles of arachidonic acid on the pathway of PG synthesis and osteoblast differentiation by using clone MC3T3-E1 cells. The effect of arachidonic acid was evaluated by the measurement of alkaline phosphatase activity, cells shape, production of arachidonic acid and the expression of cyclooxygenase (COX). Arachidonic acid dose dependently decreased alkaline phosphatase activity and increased PGE2 production in MC3T3-E1 cells. The cell shape changed from polygonal to fibroblastic following treatment with arachidonic acid. These effects were recovered by the treatment of NS-398 and indomethacin. Arachidonic acid increased the expression of COX-2 mRNA and the PGE2 production. The exogenous arachidonic acid induced the release of cellular arachidonic acid in MC3T3-E1 cells. Moreover, methylarachidonyl fluorophosphonate suppressed the arachidonic acid release and the expression of COX-2 mRNA. The present results indicate that exogenous arachidonic acid stimulated the activity of PLA2, leading to the new release of membranous arachidonic acid. The amplified arachidonic acid enhanced PGE2 production by COX-2, which inhibits the differentiation of MC3T3-E1 cells. Our results provide a new insight into the molecular mechanisms by which exogenous arachidonic acid plays a role as a paracrine/autocrine amplifier of PGE2 biosynthesis by coupling with PLA2 and COX-2.  (日)    [継承]
キーワード (推奨): 1. (英) 3T3 Cells (日) (読) [継承]
2. (英) Alkaline Phosphatase (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Arachidonic Acid (日) (読) [継承]
5. (英) Arachidonic Acids (日) (読) [継承]
6.細胞分化 (cell differentiation) [継承]
7. (英) Cell Shape (日) (読) [継承]
8. (英) Clone Cells (日) (読) [継承]
9. (英) Cyclooxygenase 2 (日) (読) [継承]
10. (英) Cyclooxygenase 2 Inhibitors (日) (読) [継承]
11. (英) Cyclooxygenase Inhibitors (日) (読) [継承]
12. (英) Cytosol (日) (読) [継承]
13. (英) Dinoprostone (日) (読) [継承]
14. (英) Enzyme Inhibitors (日) (読) [継承]
15. (英) Fibroblasts (日) (読) [継承]
16. (英) Indomethacin (日) (読) [継承]
17. (英) Mice (日) (読) [継承]
18. (英) Nitrobenzenes (日) (読) [継承]
19. (英) Osteoblasts (日) (読) [継承]
20. (英) Phospholipases A (日) (読) [継承]
21. (英) Phospholipases A2 (日) (読) [継承]
22. (英) Phosphonic Acids (日) (読) [継承]
23. (英) Prostaglandin-Endoperoxide Synthases (日) (読) [継承]
24. (英) Prostaglandins (日) (読) [継承]
25. (英) RNA, Messenger (日) (読) [継承]
26. (英) Sulfonamides (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oral Diseases (Munksgaard)
(pISSN: 1354-523X, eISSN: 1601-0825)

ISSN (任意): 1354-523X
ISSN: 1354-523X (pISSN: 1354-523X, eISSN: 1601-0825)
Title: Oral diseases
Title(ISO): Oral Dis
Publisher: Blackwell
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 13 [継承]
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(必須): 32 39 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 1月 初日 (平成 19年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1601-0825.2006.01239.x    (→Scopusで検索) [継承]
PMID (任意): 17241427    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Histology and Oral Histology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima, Japan. kaya@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kaya Yoshida, Hiroyuki Shinohara, (名) Suryono, Tatsuji Haneji and Toshihiko Nagata : Arachidonic acid inhibits osteoblast differentiation through cytosolic phospholipase A2-dependent pathway., Oral Diseases, Vol.13, No.1, 32-39, 2007.
欧文冊子 ● Kaya Yoshida, Hiroyuki Shinohara, (名) Suryono, Tatsuji Haneji and Toshihiko Nagata : Arachidonic acid inhibits osteoblast differentiation through cytosolic phospholipase A2-dependent pathway., Oral Diseases, Vol.13, No.1, 32-39, 2007.

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