『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=172051)

EID=172051EID:172051, Map:0, LastModified:2018年2月8日(木) 14:03:02, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[吉田 賀弥], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日) [継承]
2.徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座 (2007年4月1日〜) [継承]
著者 (必須): 1.岡村 裕彦
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.吉田 賀弥 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.口腔保健学系.口腔保健教育学]/[徳島大学.歯学部.口腔保健学科.口腔保健基礎学講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.森本 景之
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.羽地 達次
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) PTEN expression by Egr-1 transcription factor in calyculin A-induced apoptotic cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) PTEN is a tumor suppressor gene encoding a phosphatase that negatively regulates cell survival mediated by the PI3-kinase-Akt pathway. The gene for transcription factor EGR-1 is an early response gene essential for cellular growth, proliferation, and differentiation. Protein phosphatase inhibitors including calyculin A and okadaic acid are potent inducers of apoptosis in several cell lines; however, the molecular mechanisms underlying their action are unknown. The purpose of this study was to examine the expression of PTEN and EGR-1 and the phosphorylation status of EGR-1 and Akt in calyculin A-treated human squamous carcinoma cells (SCCTF). Phosphorylation of EGR-1 and upregulation of PTEN expression were observed to occur in SCCTF cells treated with calyculin A in time- and dose-dependent fashions. The level of phosphorylated Akt decreased as the expression of PTEN protein increased in the calyculin A-treated SCCTF cells. Calyculin A-stimulated expression of EGR-1 and PTEN might be p53 independent, because the expression of them was also detected in p53-null Saos-2 cells. RNA interference using double-stranded RNA specific for the EGR-1 gene inhibited not only EGR-1 expression but also PTEN expression in SCCTF cells treated or not with calyculin A. Calyculin A induced nuclear fragmentation and chromatin condensation in SCCTF cells. The present results suggest that the level of PTEN expression and the phosphorylation status of Akt were associated with apoptosis induced by calyculin A. These observations also support the view that EGR-1 regulates PTEN expression in the initial steps of the apoptotic pathway.  (日)    [継承]
キーワード (推奨): 1. (英) Apoptosis (日) (読) [継承]
2. (英) Base Sequence (日) (読) [継承]
3. (英) Cell Line, Tumor (日) (読) [継承]
4. (英) DNA Primers (日) (読) [継承]
5. (英) DNA-Binding Proteins (日) (読) [継承]
6. (英) Down-Regulation (日) (読) [継承]
7. (英) Early Growth Response Protein 1 (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Immediate-Early Proteins (日) (読) [継承]
10. (英) Oxazoles (日) (読) [継承]
11. (英) PTEN Phosphohydrolase (日) (読) [継承]
12. (英) Phosphoric Monoester Hydrolases (日) (読) [継承]
13. (英) Phosphorylation (日) (読) [継承]
14. (英) Transcription Factors (日) (読) [継承]
15. (英) Tumor Suppressor Proteins (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Cellular Biochemistry ([Wiley-Liss, Inc.])
(pISSN: 0730-2312, eISSN: 1097-4644)

ISSN (任意): 0730-2312
ISSN: 0730-2312 (pISSN: 0730-2312, eISSN: 1097-4644)
Title: Journal of cellular biochemistry
Title(ISO): J Cell Biochem
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 94 [継承]
(必須): 1 [継承]
(必須): 117 125 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 1月 1日 (平成 17年 1月 1日) [継承]
URL (任意):
DOI (任意): 10.1002/jcb.20283    (→Scopusで検索) [継承]
PMID (任意): 15517593    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Histology and Oral Histology, School of Dentistry, The University of Tokushima, Kuramoto, Tokushima 770-8504, Japan. okamura@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hirohiko Okamura, Kaya Yoshida, Hiroyuki Morimoto and Tatsuji Haneji : PTEN expression by Egr-1 transcription factor in calyculin A-induced apoptotic cells, Journal of Cellular Biochemistry, Vol.94, No.1, 117-125, 2005.
欧文冊子 ● Hirohiko Okamura, Kaya Yoshida, Hiroyuki Morimoto and Tatsuji Haneji : PTEN expression by Egr-1 transcription factor in calyculin A-induced apoptotic cells, Journal of Cellular Biochemistry, Vol.94, No.1, 117-125, 2005.

関連情報

Number of session users = 1, LA = 0.25, Max(EID) = 376549, Max(EOID) = 1008437.