『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=172038EID:172038, Map:0, LastModified:2018年4月20日(金) 09:23:02, Operator:[野間 隆文], Avail:TRUE, Censor:0, Owner:[野間 隆文], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.阿部 佳織
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学籍番号 (推奨): **** [ユーザ]
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2.三好 圭子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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3.武藤 太郎
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4. (英) Intan Ruspita (日) インタン ルスピタ (読) インタン ルスピタ
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学籍番号 (推奨): **** [ユーザ]
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5.堀口 大吾 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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6.永田 俊彦
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7.野間 隆文 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.分子医化学])
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題名 (必須): (英) Establishment and characterization of rat dental epithelial derived ameloblast-lineage clones.  (日)    [継承]
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要約 (任意): (英) Teeth are the hardest tissues covered with enamel produced by ameloblasts. The ameloblast differentiation is controlled by sequential epithelial-mesenchymal interactions during tooth morphogenesis. However, the molecular mechanism of ameloblast differentiation remains unclear. To address this question, we developed an in vitro assay system to evaluate the molecular mechanism of amelogenesis. First, we established dental epithelium-derived clones from 6-day-old rat incisors and established that cells of the clone SRE-G5 were the largest producers of amelogenin mRNA. Next, we analyzed the effects of several chemicals on the amelogenin expression in SRE-G5 cells. Only mitogen-activated protein kinase (MAPK) activators enhanced amelogenin mRNA expression. This finding corresponded to the immunohistochemical data showing the presence of phosphorylated forms of p38, c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK) during ameloblast differentiation. To examine the roles of MAPK signals, we compared the effects of anisomycin and sodium salicylate on the expression of tooth-related differentiation markers. Both anisomycin and sodium salicylate induced amelogenin, Abcg2, and Bmp4 mRNA and down-regulated p75NGFR mRNA. On the other hand, ALP, ectodin, Bmp2 and Fgf8 mRNA were up-regulated only by anisomycin. These results indicate that MAPK signaling functions, at least in part, as the inducer of ameloblast differentiation.  (日)    [継承]
キーワード (推奨): 1. (英) Ameloblasts (日) (読) [継承]
2. (英) Amelogenesis (日) (読) [継承]
3. (英) Amelogenin (日) (読) [継承]
4. (英) Animals (日) (読) [継承]
5. (英) Cell Differentiation (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Cloning, Molecular (日) (読) [継承]
8. (英) Epithelial Cells (日) (読) [継承]
9. (英) Incisor (日) (読) [継承]
10. (英) Rats (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Bioscience and Bioengineering ([日本生物工学会])
(pISSN: 1389-1723, eISSN: 1347-4421)

ISSN (任意): 1389-1723
ISSN: 1389-1723 (pISSN: 1389-1723, eISSN: 1347-4421)
Title: Journal of bioscience and bioengineering
Title(ISO): J. Biosci. Bioeng.
Supplier: 公益社団法人日本生物工学会
Publisher: Elsevier BV
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 103 [継承]
(必須): 5 [継承]
(必須): 479 485 [継承]
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年月日 (必須): 西暦 2007年 5月 初日 (平成 19年 5月 初日) [継承]
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DOI (任意): 10.1263/jbb.103.479    (→Scopusで検索) [継承]
PMID (任意): 17609165    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kaori Abe, Keiko Miyoshi, Taro Muto, Ruspita Intan, Taigo Horiguchi, Toshihiko Nagata and Takafumi Noma : Establishment and characterization of rat dental epithelial derived ameloblast-lineage clones., Journal of Bioscience and Bioengineering, Vol.103, No.5, 479-485, 2007.
欧文冊子 ● Kaori Abe, Keiko Miyoshi, Taro Muto, Ruspita Intan, Taigo Horiguchi, Toshihiko Nagata and Takafumi Noma : Establishment and characterization of rat dental epithelial derived ameloblast-lineage clones., Journal of Bioscience and Bioengineering, Vol.103, No.5, 479-485, 2007.

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