『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨): □Peer Review [継承]
○カテゴリ (推奨): □研究 [継承]
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日) [継承]
○著者 (必須): 1. (英) Kumegawa Masayoshi (日) (読)
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2. (英) Ikeda Eiko (日) (読)
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3. (英) Tanaka Shigeyasu (日) (読)
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4.羽地 達次
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5. (英) Yora Takao (日) (読)
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6. (英) Sakagishi Yoshikatsu (日) (読)
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7. (英) Minami Naomi (日) (読)
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8. (英) Hiramatsu Masahiko (日) (読)
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○題名 (必須): □(英) The effects of prostaglandin E2, parathyroid hormone, 1a, 25-dihydroxy-cholecalciferol and cyclic nucleotide analogs on alkaline phosphatase activity in osteoblastic cells  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Clone MC3T3-E1 cells isolated from newborn mouse calvaria had the same type of alkaline phosphatase (ALP) as that found in adult mouse calvaria (the liver-bone-kidney type), as judged by polyacrylamide gel electrophoresis as well as by heat lability and amino acid inactivation. The effects of prostaglandin E2 (PGE2), parathyroid hormone (PTH), 1,25 dihydroxycholecalciferol [1,25(OH)2D3], and adenosine-3',5'-cyclic monophosphate (cAMP) analogs on ALP were investigated. PGE2 and 1,25(OH)2D3 increased ALP activity in dose-related manner with a maximal effect at concentrations of 10 ng/ml and 40 pg/ml, respectively. N6,O2-dibutyryl adenosine-3',5'-cyclic monophosphate (DBcAMP) also induced an increase in ALP activity in a dose-related fashion with a maximal effect at a concentration of 0.5 mM which was 2.2-fold over that of the controls. Induced ALP was of the "liver-bone-kidney" type. Antinomycin D and cycloheximide inhibited the increase in ALP activity induced by DBcAMP. The level of ALP was elevated by 8-bromo-adenosine-3',5'-cyclic monophosphate and theophylline, but not by N6,O2-dibutyryl guanosine-3',5'-cyclic monophosphate and sodium butyrate. Moreover, PGE2 dramatically increased the level of cAMP in the cells with a maximal effect at a concentration of 10 ng/ml, indicating that PGE2 and DBcAMP induce an increase of ALP activity in clone MC3T3-E1 cells by increasing the cAMP level; PTH did not affect enzyme activity and cAMP level in the cells.(ABSTRACT TRUNCATED AT 250 WORDS)  (日)    [継承]
○キーワード (推奨): 1. (英) Alkaline Phosphatase (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Butyrates (日) (読) [継承]
4. (英) Butyric Acid (日) (読) [継承]
5. (英) Clone Cells (日) (読) [継承]
6. (英) Cyclic AMP (日) (読) [継承]
7. (英) Dihydroxycholecalciferols (日) (読) [継承]
8. (英) Dinoprostone (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred C57BL (日) (読) [継承]
11. (英) Osteoblasts (日) (読) [継承]
12. (英) Parathyroid Hormone (日) (読) [継承]
13. (英) Prostaglandins E (日) (読) [継承]
14. (英) Theophylline (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Calcified Tissue International (International Osteoporosis Foundation)
(pISSN: 0171-967X, eISSN: 1432-0827)

○ISSN (任意): □0171-967X
ISSN: 0171-967X (pISSN: 0171-967X, eISSN: 1432-0827)
Title: Calcified tissue international
Title(ISO): Calcif Tissue Int
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □36 [継承]
○号 (必須): □1 [継承]
○頁 (必須): □72 76 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1984年 1月 初日 (昭和 59年 1月 初日) [継承]
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○PMID (任意): □6322941    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Masayoshi Kumegawa, Eiko Ikeda, Shigeyasu Tanaka, Tatsuji Haneji, Takao Yora, Yoshikatsu Sakagishi, Naomi Minami and Masahiko Hiramatsu : The effects of prostaglandin E2, parathyroid hormone, 1a, 25-dihydroxy-cholecalciferol and cyclic nucleotide analogs on alkaline phosphatase activity in osteoblastic cells, Calcified Tissue International, Vol.36, No.1, 72-76, 1984.
欧文冊子 ● Masayoshi Kumegawa, Eiko Ikeda, Shigeyasu Tanaka, Tatsuji Haneji, Takao Yora, Yoshikatsu Sakagishi, Naomi Minami and Masahiko Hiramatsu : The effects of prostaglandin E2, parathyroid hormone, 1a, 25-dihydroxy-cholecalciferol and cyclic nucleotide analogs on alkaline phosphatase activity in osteoblastic cells, Calcified Tissue International, Vol.36, No.1, 72-76, 1984.

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