『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.湯浅 恵造 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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2. (英) Suzue Kaori (日) (読)
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3.長浜 正巳
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4.松田 佳子
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5.辻 明彦
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題名 (必須): (英) Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: Possible role of E2F-mediated upregulation of PACE4 in tumor progression  (日)    [継承]
副題 (任意):
要約 (任意): (英) PACE4, a member of the subtilisin-like proprotein convertase (SPC) family, is expressed at high levels in certain tumor cells and plays a role in metastatic progression through activation of matrix metalloproteinases. The mechanism leading to overexpression of PACE4 in tumor cells remains unclear. In this study, we show that the E2F1 transcription factor, which is implicated in carcinoma invasiveness, upregulates the expression of PACE4. HT1080 (highly tumorigenic and invasive) cells expressed much higher levels of PACE4 and E2F family (E2F1 and E2F2) transcripts than IMR90 (normal fibroblast) cells. Expression levels of other SPCs (furin and PC6) remained unchanged in these cells. Promoter analysis indicated that two E2F consensus binding sites (-117/-110 and -86/-79) in the 5'-flanking region of the human PACE4 gene function as positive regulatory elements. Mutation of these sites abolished PACE4 promoter response to E2F1 as well as binding of E2F1 in electrophoretic mobility-shift assays. Other E2F members, E2F2 and E2F3, also activated PACE4 expression, as in the case of E2F1. These results indicate a novel mechanism for E2F family-mediated promotion of carcinoma invasiveness through PACE4.  (日)    [継承]
キーワード (推奨): 1. (英) Binding Sites (日) (読) [継承]
2. (英) Cell Line, Tumor (日) (読) [継承]
3. (英) Disease Progression (日) (読) [継承]
4. (英) E2F Transcription Factors (日) (読) [継承]
5. (英) E2F1 Transcription Factor (日) (読) [継承]
6. (英) Electrophoretic Mobility Shift Assay (日) (読) [継承]
7. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Neoplasms (日) (読) [継承]
10. (英) Promoter Regions, Genetic (日) (読) [継承]
11. (英) Proprotein Convertases (日) (読) [継承]
12. (英) Serine Endopeptidases (日) (読) [継承]
13. (英) Transcription, Genetic (日) (読) [継承]
14. (英) Transfection (日) (読) [継承]
15. (英) Up-Regulation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Gene ([Elsevier Science B.V.])
(pISSN: 0378-1119, eISSN: 1879-0038)

ISSN (任意): 0378-1119
ISSN: 0378-1119 (pISSN: 0378-1119, eISSN: 1879-0038)
Title: Gene
Title(ISO): Gene
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 402 [継承]
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(必須): 103 110 [継承]
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年月日 (必須): 西暦 2007年 8月 10日 (平成 19年 8月 10日) [継承]
URL (任意):
DOI (任意): 10.1016/j.gene.2007.07.028    (→Scopusで検索) [継承]
PMID (任意): 17825503    (→Scopusで検索) [継承]
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WOS (任意): 000250195900012 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Biological Science and Technology, The University of Tokushima Graduate School, 2-1 Minamijosanjima, Tokushima 770-8506, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Keizo Yuasa, Kaori Suzue, Masami Nagahama, Yoshiko Matsuda and Akihiko Tsuji : Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: Possible role of E2F-mediated upregulation of PACE4 in tumor progression, Gene, Vol.402, No.1-2, 103-110, 2007.
欧文冊子 ● Keizo Yuasa, Kaori Suzue, Masami Nagahama, Yoshiko Matsuda and Akihiko Tsuji : Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: Possible role of E2F-mediated upregulation of PACE4 in tumor progression, Gene, Vol.402, No.1-2, 103-110, 2007.

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