『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=166614EID:166614, Map:0, LastModified:2017年12月20日(水) 12:02:33, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.総合科学部.社会創生学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.人間·自然環境研究科.自然環境専攻 (1994年4月1日〜2011年3月31日) [継承]
著者 (必須): 1. (英) Nakamura Yuki (日) (読)
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2.山本 裕史
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3.関澤 純
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4. (英) Kondo Takuya (日) (読)
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5. (英) Hirai Narisato (日) (読)
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6. (英) Tatarazako Norihisa (日) (読)
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題名 (必須): (英) The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes)  (日)    [継承]
副題 (任意): (英) Acute toxicity in fish larvae and bioaccumulation in juvenile fish  (日)    [継承]
要約 (任意): (英) Recent detection of fluoxetine in the aquatic environment and fish suggests a possibly high accumulation of fluoxetine; however, no report is available on the bioaccumulation of fluoxetine in aquatic organisms. Since bioaccumulation of fluoxetine was probably dependent on pH near the pK(a) value of 10.1, experiments were conducted approximately at pH 7, 8, and 9. Distribution coefficients between 1-octanol and water (D(ow)), and those between synthetic membrane vesicles (liposomes) and water (D(lip-wat)) were determined at pH 7, 8, and 9. The D(ow) and D(lip-wat) values increased significantly with increasing pH. Acute toxicity tests were performed using Japanese medaka (Oryzias latipes) prior to the bioaccumulation test, and 96-h LC(50) values were 5.5, 1.3, and 0.20mgl(-1) at pH 7, 8, and 9, respectively. In the bioaccumulation test, concentrations of fluoxetine and its major metabolite, norfluoxetine, in the fish body and liver were measured. The bioconcentration factors (BCF) of fluoxetine for Japanese medaka were 8.8, 3.0x10, and 2.6x10(2) in the body and 3.3x10(2), 5.8x10(2), and 3.1x10(3) in the liver at pH 7, 8, and 9, respectively. The BCF values were lower at pH 7 and higher at pH 9 mainly because of the increase in nonionized species with significantly higher hydrophobicity than the ionized species at pH values closer to pK(a). A similar trend was obtained for the concentration of norfluoxetine in the fish but the pseudo-BCF values (the ratio of the norfluoxetine concentration in the fish and the fluoxetine concentration in test water) were higher than the BCF value of fluoxetine at all pH conditions.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Environmental Monitoring (日) (読) [継承]
3. (英) Fishes (日) (読) [継承]
4. (英) Fluoxetine (日) (読) [継承]
5. (英) Hydrogen-Ion Concentration (日) (読) [継承]
6. (英) Larva (日) (読) [継承]
7. (英) Oryzias (日) (読) [継承]
8. (英) Risk Assessment (日) (読) [継承]
9. (英) Tissue Distribution (日) (読) [継承]
10. (英) Water Pollutants, Chemical (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Chemosphere ([Elsevier])
(pISSN: 0045-6535, eISSN: 1879-1298)

ISSN (任意): 0045-6535
ISSN: 0045-6535 (pISSN: 0045-6535, eISSN: 1879-1298)
Title: Chemosphere
Title(ISO): Chemosphere
Publisher: Elsevier Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2008年 1月 初日 (平成 20年 1月 初日) [継承]
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DOI (任意): 10.1016/j.chemosphere.2007.06.089    (→Scopusで検索) [継承]
PMID (任意): 17765944    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-36248958726 [継承]
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備考 (任意): 1.(英) Article.Affiliation: University of Tokushima, Department of Mathematical and Natural Sciences, 1-1, Minamijosanjima-cho, Tokushima 770-8502, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yuki Nakamura, Hiroshi Yamamoto, Jun Sekizawa, Takuya Kondo, Narisato Hirai and Norihisa Tatarazako : The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes), --- Acute toxicity in fish larvae and bioaccumulation in juvenile fish ---, Chemosphere, Vol.70, No.5, 865-873, 2008.
欧文冊子 ● Yuki Nakamura, Hiroshi Yamamoto, Jun Sekizawa, Takuya Kondo, Narisato Hirai and Norihisa Tatarazako : The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes), --- Acute toxicity in fish larvae and bioaccumulation in juvenile fish ---, Chemosphere, Vol.70, No.5, 865-873, 2008.

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