| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 小瀬 博之
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 酒井 徹 ([徳島大学.大学院医歯薬学研究部.医学域.栄養科学部門.医科栄養学系.実践栄養学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 九十九 伸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | (英) Wei Kaichun (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 5. | (英) Yamada Takahisa (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 6. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 7. | 松本 耕三
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase κ gene in LEC rats (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The Long-Evans Cinnamon (LEC) rat has a spontaneous mutation, T helper immunodeficiency (thid), which causes a markedly reduced CD4(+) thymocyte population. Here we positionally clone the locus and identify a deletion in the gene encoding a receptor-like protein tyrosine phosphatase kappa (Ptprk) that led to complete loss of the transcript. The rat Ptprk gene exhibits 98% identity with the human and mouse counterparts and is expressed most abundantly in the CD4(-)CD8(-) double-negative stage. The downregulation of Ptprk in mouse immature thymocytes by RNA interference mimicked the thid phenotype. These results indicate that thid maps to the Ptprk locus and that functional Ptprk is crucial for lineage commitment or progression of CD4(+) T cells. We also found that Ptprk appears to function in parallel with or downstream of Th-POK/cKrox (also known as ZBTB7B), a master regulator of T cell lineage decision. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) T cell differentiation (日) (読)
| [継承] |
| 2. | (英) Protein phosphatase (日) (読)
| [継承] |
| 3. | (英) LEC rat (日) (読)
| [継承] |
| 4. | (英) Thymus (日) (読)
| [継承] |
| 5. | (英) Th-POK/cKrox (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Genomics ([Elsevier])
(pISSN: 0888-7543, eISSN: 1089-8646)
| ○ISSN (任意): | □ | 0888-7543
ISSN: 0888-7543
(pISSN: 0888-7543, eISSN: 1089-8646) Title: GenomicsTitle(ISO): GenomicsPublisher: Academic Press Inc. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 89
| [継承] |
| ○号 (必須): | □ | 6
| [継承] |
| ○頁 (必須): | □ | 673 677
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2007年 4月 16日 (平成 19年 4月 16日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.ygeno.2007.03.001 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 17434290 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Division of Animal Research Resources, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. (日)
| [継承] |
| 2. | (英) Article.DataBankList.DataBank.DataBankName: GENBANK (日)
| [継承] |
| 3. | (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AB288087 (日)
| [継承] |
| 4. | (英) Article.DataBankList.DataBank.AccessionNumberList.AccessionNumber: AB288088 (日)
| [継承] |
| 5. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 6. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
| [継承] |