『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=166287)

EID=166287EID:166287, Map:0, LastModified:2018年6月14日(木) 17:01:43, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[加藤 真介], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1. (英) Abbaspour Aziz (日) (読)
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2.髙田 信二郎
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3.松井 好人
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4.加藤 真介
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5.高橋 光彦
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6.安井 夏生
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題名 (必須): (英) Continuous infusion of insulin-like growth factor-I into the epiphysis of the tibia.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have developed a method to promote longitudinal bone growth at the level of a specific growth-plate (GP) in young rabbits. Insulin-like growth factor-I (IGF-I) was continuously infused by means of an osmotic pump into the bone marrow cavity of the proximal epiphysis of the tibia. Radiological measurement showed a 2-mm overgrowth of the tibia after 4 weeks of treatment, while histological analysis demonstrated a 15% increase in the thickness of the selected GP. The local infusion of IGF-I increased the numbers of both proliferative and hypertrophic chondrocytes and promoted hyperplasia of bony trabeculae within the epiphysis. The distribution of material infused locally into the epiphysis was simulated by the infusion of Indian ink using the same methodology (osmotic pump) as that for IGF-I. Most of the dye remained within the bone marrow cavity of the epiphysis, but a portion infiltrated into the GP, reaching the deep layer of the physeal chondrocytes and primary spongiosa of the metaphysis. These results suggest that the method reported here is a valid one for delivering cytokines or growth factors to the selected GP and for controlling the growth and differentiation of physeal chondrocytes.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Bone Development (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Chondrocytes (日) (読) [継承]
5. (英) Epiphyses (日) (読) [継承]
6. (英) Growth Plate (日) (読) [継承]
7. (英) Infusion Pumps, Implantable (日) (読) [継承]
8. (英) Infusions, Intraosseous (日) (読) [継承]
9. (英) Insulin-Like Growth Factor I (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Rabbits (日) (読) [継承]
12. (英) Tibia (日) (読) [継承]
13. (英) Tomography (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Orthopaedics (Société internationale de chirurgie orthopédique et de traumatologie)
(pISSN: 0341-2695, eISSN: 1432-5195)

ISSN (任意): 0341-2695
ISSN: 0341-2695 (pISSN: 0341-2695, eISSN: 1432-5195)
Title: International orthopaedics
Title(ISO): Int Orthop
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2008年 0月 初日 (平成 20年 0月 初日) [継承]
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DOI (任意): 10.1007/s00264-007-0336-7    (→Scopusで検索) [継承]
PMID (任意): 17431620    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Orthopedics, Institute of Health Biosciences, the University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) OtherID: PMC2323423  (日)    [継承]

標準的な表示

和文冊子 ● Aziz Abbaspour, Shinjiro Takata, Yoshito Matsui, Shinsuke Katoh, Mitsuhiko Takahashi and Natsuo Yasui : Continuous infusion of insulin-like growth factor-I into the epiphysis of the tibia., International Orthopaedics, Vol.32, No.3, 395-402, 2008.
欧文冊子 ● Aziz Abbaspour, Shinjiro Takata, Yoshito Matsui, Shinsuke Katoh, Mitsuhiko Takahashi and Natsuo Yasui : Continuous infusion of insulin-like growth factor-I into the epiphysis of the tibia., International Orthopaedics, Vol.32, No.3, 395-402, 2008.

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