『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1.高橋 光彦
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2.油形 公則
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3.松井 好人
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4. (英) Abbaspour Aziz (日) (読)
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5.髙田 信二郎
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6.安井 夏生
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題名 (必須): (英) Bisphosphonate Modulates Morphological and Mechanical Properties in Distraction Osteogenesis through Inhibition of Bone Resorption.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Despite the general clinical acceptance of distraction osteogenesis and much attention to bone formation in this method, little is recognized about activated bone resorption in the regenerated bone. The purpose of this study was to demonstrate the simultaneously activated bone resorption with activated bone formation and to investigate the role and efficacy of bisphosphonate in distraction osteogenesis. Left tibiae of 54 immature rabbits were lengthened for 3 weeks at a rate of 0.7 mm/day after a 1-week lag. Regenerated bone was quantitatively investigated by radiographic bone density, bone histomorphometry, and three-point bending testing. Animals received either vehicle or nitrogen-containing bisphosphonate (N-BP), YM529/ONO5920 at doses of 0.4 mg/kg/w or 0.004 mg/kg/w for 6 weeks. Regenerated bone of the vehicle group showed a radiologically characteristic zone structure containing the osteopenic zones adjacent to the sclerotic zones. The regenerated bone of the 0.4-mg/kg/w group showed no osteopenic zones during the course and eventually became homogeneously radiodense. The bone volume corresponding to the osteopenic zone of this group was 5.6-fold greater compared with that of the vehicle group. The lengthened bone strength of this group was 3.3-fold greater in ultimate force than that of the vehicle group and equivalent to the contralateral tibia. The 0.004-mg/kg/w group had no substantial differences compared with the vehicle group, despite radiological enhancement of the mineralized front as well as somewhat delayed bone resorption. These results demonstrate that not only bone formation but also bone resorption is highly activated in the regenerated bone, implying high bone turnover. Sufficient N-BP caused a notable modulation in morphological properties of the regenerated bone through inhibition of highly activated bone resorption and eventually increased mechanical properties.  (日)    [継承]
キーワード (推奨): 1. (英) Absorptiometry, Photon (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Bone Resorption (日) (読) [継承]
4. (英) Calcification, Physiologic (日) (読) [継承]
5. (英) Diphosphonates (日) (読) [継承]
6. (英) Male (日) (読) [継承]
7. (英) Osteogenesis (日) (読) [継承]
8. (英) Rabbits (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Bone (International Bone and Mineral Society)
(pISSN: 8756-3282, eISSN: 1873-2763)

ISSN (任意): 8756-3282
ISSN: 8756-3282 (pISSN: 8756-3282, eISSN: 1873-2763)
Title: Bone
Title(ISO): Bone
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 39 [継承]
(必須): 3 [継承]
(必須): 573 581 [継承]
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年月日 (必須): 西暦 2006年 1月 1日 (平成 18年 1月 1日) [継承]
URL (任意):
DOI (任意): 10.1016/j.bone.2006.03.010    (→Scopusで検索) [継承]
PMID (任意): 16713413    (→Scopusで検索) [継承]
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WOS (任意): 000240113900017 [継承]
Scopus (任意): 2-s2.0-33746609766 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Orthopedics, Institute of Health Biosciences, the University of Tokushima Graduate School, 3-18-15, Kuramoto, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mitsuhiko Takahashi, Kiminori Yukata, Yoshito Matsui, Aziz Abbaspour, Shinjiro Takata and Natsuo Yasui : Bisphosphonate Modulates Morphological and Mechanical Properties in Distraction Osteogenesis through Inhibition of Bone Resorption., Bone, Vol.39, No.3, 573-581, 2006.
欧文冊子 ● Mitsuhiko Takahashi, Kiminori Yukata, Yoshito Matsui, Aziz Abbaspour, Shinjiro Takata and Natsuo Yasui : Bisphosphonate Modulates Morphological and Mechanical Properties in Distraction Osteogenesis through Inhibition of Bone Resorption., Bone, Vol.39, No.3, 573-581, 2006.

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