| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部 (2004年4月1日〜2015年3月31日)
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| ○著者 (必須): | 1. | 東野 恒作
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| 2. | 松井 好人
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| ○貢献度 (任意): |
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| 3. | (英) Yagi Syoji (日) (読)
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| 4. | (英) Takata Yoichiro (日) (読)
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| 5. | (英) Goto Tomohiro (日) (読)
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| 6. | 酒井 紀典 ([徳島大学.病院.中央診療施設等.高度先進整形外科診療部])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 7. | 加藤 真介
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| 8. | 安井 夏生
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| ○題名 (必須): | □ | (英) The alpha2 type IX collagen tryptophan polymorphism is associated with the severity of disc degeneration in younger patients with herniated nucleus pulposus of the lumbar spine. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Tryptophan alleles in COL9A2 (Trp2) and COL9A3 (Trp3) have been linked to lumbar disc diseases in the Finnish population. Although such diseases consist of various pathogenetically different conditions, detailed analysis of each has not been well documented. The aim of this study was to clarify whether the collagen IX tryptophan alleles influence the symptomatic degeneration of the lumbar disc in Japanese patients with herniated nucleus pulposus. We performed a prospective study of 84 patients who underwent lumbar discectomy. The degree of disc degeneration was evaluated by magnetic resonance images in relation to the collagen IX genotype. Twenty patients (21.4%) had the Trp2 allele and no patients had the Trp3 allele. Patients under 40 years with the Trp2 allele showed more severe disc degeneration at the surgical level than did those without the Trp2 allele (odds ratio 6.00, P=0.043). In contrast, patients aged 40 years or over did not show significant association between disc degeneration and collagen IX genotype. Our results suggest that the Trp2 allele is an age-dependent risk factor for the severity of disc degeneration in younger patients with symptomatic herniated nucleus pulposus of the lumbar spine. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Collagen Type IX (日) (読)
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| 3. | (英) Female (日) (読)
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| 4. | (英) Genetic Predisposition to Disease (日) (読)
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| 5. | (英) Humans (日) (読)
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| 6. | (英) Intervertebral Disc (日) (読)
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| 7. | (英) Intervertebral Disc Displacement (日) (読)
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| 8. | (英) Lumbar Vertebrae (日) (読)
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| 9. | (英) Magnetic Resonance Imaging (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Odds Ratio (日) (読)
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| 12. | (英) Polymorphism, Genetic (日) (読)
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| 13. | (英) Prospective Studies (日) (読)
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| 14. | (英) Risk Factors (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | International Orthopaedics (Société internationale de chirurgie orthopédique et de traumatologie)
(pISSN: 0341-2695, eISSN: 1432-5195)
| ○ISSN (任意): | □ | 0341-2695
ISSN: 0341-2695
(pISSN: 0341-2695, eISSN: 1432-5195) Title: International orthopaedicsTitle(ISO): Int OrthopSupplier: Springer Online Journal ArchivePublisher: Springer (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 31
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 107 111
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2007年 1月 1日 (平成 19年 1月 1日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1007/s00264-006-0117-8 (→Scopusで検索)
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| ○PMID (任意): | □ | 16586133 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Orthopedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 4. | (英) OtherID: PMC2267527 (日)
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