『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.生命情報工学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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2.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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3.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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4.堀 均
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5. (英) Nagata Kenji (日) (読)
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6. (英) Suzuki Minoru (日) (読)
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7. (英) Kashino G (日) (読)
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8. (英) Kinashi Yuko (日) (読)
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9. (英) Ono Koji (日) (読)
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題名 (必須): (英) The usefulness of mild temperature hyperthermia combined with continuous tirapazamine administration under reduced dose-rate irradiation with gamma-rays  (日)    [継承]
副題 (任意):
要約 (任意): (英) We clarified the usefulness of mild temperature hyperthermia (MTH) in combination with the continuous administration of tirapazamine (TPZ) under reduced dose-rate irradiation (RDRI) using gamma-rays. SCC VII tumour-bearing mice received a continuous administration of 5-bromo-2'-deoxyuridine (BrdU) to label all proliferating (P) cells. Then, they received a 24 h continuous subcutaneous infusion of TPZ either with or without MTH under high dose-rate irradiation (HDRI) or RDRI using gamma-rays. After the irradiation, the tumour cells were isolated and incubated with a cytokinesis blocker, and the micronucleus (MN) frequency in non-proliferating tumour cells without BrdU labeling (= quiescent (Q) cells) was determined using immunofluorescence staining for BrdU. The MN frequency in the total tumour cell populations was determined using tumours that were not pretreated with BrdU. The sensitivity of both the total and Q cell populations, especially the latter, was significantly reduced with RDRI compared with HDRI. TPZ increased the sensitivity of both populations, with a slightly more remarkable increase in Q cells. Further, MTH combined with TPZ raised the sensitivity of both the total and Q cell populations, especially the latter, under RDRI more markedly than under HDRI. From the viewpoint of solid tumour control as a whole, including intratumour Q-cell control, the use of TPZ, especially in combination with MTH, is useful for suppressing the reduction in the sensitivity of tumour cells caused by the decrease in irradiation dose rate in vivo.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antineoplastic Agents (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) Cell Line, Tumor (日) (読) [継承]
5. (英) Cell Survival (日) (読) [継承]
6. (英) Combined Modality Therapy (日) (読) [継承]
7. (英) Fever (日) (読) [継承]
8. (英) Gamma Rays (日) (読) [継承]
9. (英) Humans (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Radiation-Sensitizing Agents (日) (読) [継承]
12. (英) Triazines (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Hyperthermia (Society for Thermal Medicine/European Society for Hyperthermic Oncology/Japanese Society for Thermal Medicine)
(pISSN: 0265-6736, eISSN: 1464-5157)

ISSN (任意): 0265-6736
ISSN: 0265-6736 (pISSN: 0265-6736, eISSN: 1464-5157)
Title: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Title(ISO): Int J Hyperthermia
Publisher: Taylor & Francis
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 29 35 [継承]
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年月日 (必須): 西暦 2007年 2月 初日 (平成 19年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.1080/02656730601135366    (→Scopusで検索) [継承]
PMID (任意): 17575721    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan. smasuna@rri.kyoto-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Evaluation Studies  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori, Kenji Nagata, Minoru Suzuki, G Kashino, Yuko Kinashi and Koji Ono : The usefulness of mild temperature hyperthermia combined with continuous tirapazamine administration under reduced dose-rate irradiation with gamma-rays, International Journal of Hyperthermia, Vol.23, No.1, 29-35, 2007.
欧文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori, Kenji Nagata, Minoru Suzuki, G Kashino, Yuko Kinashi and Koji Ono : The usefulness of mild temperature hyperthermia combined with continuous tirapazamine administration under reduced dose-rate irradiation with gamma-rays, International Journal of Hyperthermia, Vol.23, No.1, 29-35, 2007.

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