『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=166069EID:166069, Map:0, LastModified:2012年10月13日(土) 20:26:34, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術レター (ショートペーパー) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.生命情報工学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1. (英) Ahn Mok-Ryeon (日) (読)
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[継承]
2. (英) Kunimasa Kazuhiro (日) (読)
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[継承]
3. (英) Ohta Toshiro (日) (読)
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[継承]
4. (英) Kumazawa Shigenori (日) (読)
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[継承]
5. (英) Kamihira Miya (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Kaji Kazuhiko (日) (読)
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学籍番号 (推奨):
[継承]
7.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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[継承]
8.堀 均
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[継承]
9.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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[継承]
10. (英) Nakayama Tsutomu (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation  (日)    [継承]
副題 (任意):
要約 (任意): (英) Propolis, a resinous substance collected by honeybees from various plant sources, possesses various physiological activities such as antitumor effects. We have previously shown that propolis of Brazilian origin was composed mainly of artepillin C and that its constituents were quite different from those of propolis of European origin. In this report, we examined an antiangiogenic effects of Brazilian propolis and investigated whether artepillin C was responsible for such effects. In an in vivo angiogenesis assay using ICR mice, we found that the ethanol extract of Brazilian propolis (EEBP) significantly reduced the number of newly formed vessels. EEBP also showed antiangiogenic effects in an in vitro tube formation assay. When compared with other constituents of EEBP, only artepillin C was found to significantly inhibit the tube formation of HUVECs in a concentration-dependent manner (3.13-50microg/ml). In addition, artepillin C significantly suppressed the proliferation of HUVECs in a concentration-dependent manner (3.13-50microg/ml). Furthermore, artepillin C significantly reduced the number of newly formed vessels in an in vivo angiogenesis assay. Judging from its antiangiogenic activity in vitro and in vivo, we concluded that artepillin C at least in part is responsible for the antiangiogenic activity of EEBP in vivo. Artepillin C may prove useful in the development of agents and foods with therapeutic or preventive activity against tumor angiogenesis.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Brazil (日) (読) [継承]
3. (英) Cell Proliferation (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Endothelium, Vascular (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Neoplasms (日) (読) [継承]
9. (英) Neovascularization, Pathologic (日) (読) [継承]
10. (英) Phenylpropionates (日) (読) [継承]
11. (英) Propolis (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Cancer Letters (Elsevier Ireland Ltd.)
(pISSN: 0304-3835, eISSN: 1872-7980)

ISSN (任意): 0304-3835
ISSN: 0304-3835 (pISSN: 0304-3835, eISSN: 1872-7980)
Title: Cancer letters
Title(ISO): Cancer Lett.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 252 [継承]
(必須): 2 [継承]
(必須): 235 243 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 3月 6日 (平成 19年 3月 6日) [継承]
URL (任意):
DOI (任意): 10.1016/j.canlet.2006.12.039    (→Scopusで検索) [継承]
PMID (任意): 17343983    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Laboratory of Functional Food Science and COE Program in the 21st Century, School of Food and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mok-Ryeon Ahn, Kazuhiro Kunimasa, Toshiro Ohta, Shigenori Kumazawa, Miya Kamihira, Kazuhiko Kaji, Yoshihiro Uto, Hitoshi Hori, Hideko Nagasawa and Tsutomu Nakayama : Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation, Cancer Letters, Vol.252, No.2, 235-243, 2007.
欧文冊子 ● Mok-Ryeon Ahn, Kazuhiro Kunimasa, Toshiro Ohta, Shigenori Kumazawa, Miya Kamihira, Kazuhiko Kaji, Yoshihiro Uto, Hitoshi Hori, Hideko Nagasawa and Tsutomu Nakayama : Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation, Cancer Letters, Vol.252, No.2, 235-243, 2007.

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