『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=166063)

EID=166063EID:166063, Map:0, LastModified:2009年11月10日(火) 15:22:28, Operator:[山田 美緒], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 国際会議 [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.生命情報工学 (2006年4月1日〜2016年3月31日) [継承]
著者 (必須): 1.堀 均
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Koyama Daisuke (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Otsuki Mamoru (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Otomo Naoki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Shirai Tadashi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Abe Chiaki (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
8.中田 栄司
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
9.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) A chemical biosynthesis design for antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on ``isoprenomics''  (日)    [継承]
副題 (任意):
要約 (任意): (英) Tocopherols constitute members of the vitamin E group and act as a potent lipid peroxidation inhibitor against for cell membrane such as blood vessels. Phytyl quinols, namely acyclic tocopherols, are key intermediate of tocopherol biosynthesis, but their biological activities remain unclear. We therefore investigated the structure-activity relationship of phytyl quinols to apply chemical biosynthesis design for an antiatherosclerosis drug. We have achieved the biosynthesis-oriented design and synthesis of alpha- (TX-2254) and beta- (TX-2247) phytyl quinol as an unnatural intermediate, other gamma- (TX-2242) and delta- (TX-2231) phytyl quinol as a natural one. Free radical reactivity was determined by using DPPH radical. Inhibitory activity of human low density lipoprotein (LDL) oxidation was measured by TBARS assay. Free radical reactivity of TX-2242 (EC50 = 24.6 microM) and TX-2231 (24.2 microM) were equal with DL-alpha-tocopherol (22.3 microM), whereas TX-2254 (38.0 microM) and TX-2247 (30.2 microM) showed lower reactivity than DL-alpha-tocopherol. TX-2242 (IC50 = 61 microM) and TX-2231 (69 microM) also showed almost same LDL antioxidant activity as DL-alpha-tocopherol (64 microM), while TX-2254 (149 microM) and TX-2247 (254 microM) showed lower antioxidant activity than DL-alpha-tocopherol. We suggested from these results that the cyclization of phytyl quinol to tocopherol is not indispensable for the appearance of the potent antioxidant activity. We also have found an interesting negative correlation between methylation and antioxidant activity of phytyl quinols. We will present ex vivo antioxidant activity for blood vessels in the chick embryo chorioallantoic membranes (CAM) as an alternative in vivo model.  (日)    [継承]
キーワード (推奨):
発行所 (推奨):
誌名 (必須): (英) ISOTT2007 (2007 International Society on Oxygen Transport to Tissue Conference) (日) (読)
ISSN (任意):
[継承]
(必須): [継承]
(必須): [継承]
(必須): [継承]
都市 (必須): (英) Uppsala, Sweden (日) (読) [継承]
年月日 (必須): 西暦 2007年 8月 28日 (平成 19年 8月 28日) [継承]
URL (任意):
DOI (任意):
PMID (任意):
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意):

標準的な表示

和文冊子 ● Hitoshi Hori, Yoshihiro Uto, Daisuke Koyama, Mamoru Otsuki, Naoki Otomo, Tadashi Shirai, Chiaki Abe, Eiji Nakata and Hideko Nagasawa : A chemical biosynthesis design for antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on ``isoprenomics'', ISOTT2007 (2007 International Society on Oxygen Transport to Tissue Conference), Uppsala, Sweden, Aug. 2007.
欧文冊子 ● Hitoshi Hori, Yoshihiro Uto, Daisuke Koyama, Mamoru Otsuki, Naoki Otomo, Tadashi Shirai, Chiaki Abe, Eiji Nakata and Hideko Nagasawa : A chemical biosynthesis design for antiatherosclerosis drug by acyclic tocopherol intermediate analogue based on ``isoprenomics'', ISOTT2007 (2007 International Society on Oxygen Transport to Tissue Conference), Uppsala, Sweden, Aug. 2007.

関連情報

Number of session users = 0, LA = 0.88, Max(EID) = 361737, Max(EOID) = 968003.