『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.再生修復医歯学部門.感覚運動系病態医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.北村 修
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2.徳永 逸夫
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3.後藤田 貴子
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4.久保 真一
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題名 (必須): (英) Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users  (日)    [継承]
副題 (任意):
要約 (任意): (英) Methamphetamine (METH) has been shown to induce neurotoxicity. In a previous human study using quantitative Western blotting and radioligand binding assay, dopaminergic terminal marker deficits were induced in chronic METH users. In this study, we examined the suitability of the immunohistochemical detection of tyrosine hydroxylase (TH), dopamine transporter (DAT), and vesicular monoamine transporter-2 (VMAT2) levels, and caspase-3 activation in the striatum to diagnose METH abuse. Decreases in TH immunoreactivity in the nucleus accumbens and DAT in the nucleus accumbens and putamen were induced in METH users, whereas a significant difference of VMAT2 was not evident between METH and control groups. However, in the nucleus accumbens of two METH users, levels of VMAT2, a stable marker of striatal dopaminergic terminal integrity, were reduced remarkably. These findings might indicate that dopaminergic terminal degeneration is induced in the striatum of some METH abusers. On the other hand, we observed little caspase-3 activation, indicative of apoptosis, in the striatal neurons of chronic METH users. Overall, the findings of dopaminergic terminal markers were similar to those in the previous human study. Therefore, it is suggested that immunohistochemical techniques could be used to examine dopaminergic terminal marker levels and could also give useful information on chronic and/or lethal METH use in cases of METH-related death, where METH intoxication may not be toxicologically demonstrated.  (日)    [継承]
キーワード (推奨): 1. (英) Adolescent (日) (読) [継承]
2. (英) Adult (日) (読) [継承]
3. (英) Amphetamine-Related Disorders (日) (読) [継承]
4. (英) Basal Ganglia (日) (読) [継承]
5. (英) Biological Markers (日) (読) [継承]
6. (英) Case-Control Studies (日) (読) [継承]
7. (英) Caspase 3 (日) (読) [継承]
8. (英) Dopamine Agents (日) (読) [継承]
9. (英) Dopamine Plasma Membrane Transport Proteins (日) (読) [継承]
10. (英) Female (日) (読) [継承]
11. (英) Forensic Toxicology (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13.免疫組織化学 (immunohistochemistry) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Methamphetamine (日) (読) [継承]
16. (英) Tyrosine 3-Monooxygenase (日) (読) [継承]
17. (英) Vesicular Monoamine Transport Proteins (日) (読) [継承]
発行所 (推奨): Springer-Verlag [継承]
誌名 (必須): International Journal of Legal Medicine (International Academy of Legal Medicine)
(pISSN: 0937-9827, eISSN: 1437-1596)

ISSN (任意): 0937-9827
ISSN: 0937-9827 (pISSN: 0937-9827, eISSN: 1437-1596)
Title: International journal of legal medicine
Title(ISO): Int J Legal Med
Supplier: Springer Online Journal Archive
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 121 [継承]
(必須): 3 [継承]
(必須): 163 168 [継承]
都市 (任意): ベルリン (Berlin/[ドイツ連邦共和国]) [継承]
年月日 (必須): 西暦 2007年 3月 初日 (平成 19年 3月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s00414-006-0087-9    (→Scopusで検索) [継承]
PMID (任意): 16622715    (→Scopusで検索) [継承]
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WOS (任意): 000246264500001 [継承]
Scopus (任意): 2-s2.0-34249882439 [継承]
評価値 (任意): **** [制限]
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備考 (任意): 1.(英) Article.Affiliation: Department of Forensic Medicine, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan. northv@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Osamu Kitamura, Itsuo Tokunaga, Takako Gotohda and Shin-ichi Kubo : Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users, International Journal of Legal Medicine, Vol.121, No.3, 163-168, 2007.
欧文冊子 ● Osamu Kitamura, Itsuo Tokunaga, Takako Gotohda and Shin-ichi Kubo : Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users, International Journal of Legal Medicine, Vol.121, No.3, 163-168, 2007.

関連情報

Number of session users = 1, LA = 0.72, Max(EID) = 383263, Max(EOID) = 1024353.