『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=164629EID:164629, Map:0, LastModified:2013年7月19日(金) 18:43:02, Operator:[細川 義隆], Avail:TRUE, Censor:0, Owner:[細川 義隆], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.The Forsyth Institute, Department of Immunology [継承]
著者 (必須): 1.細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.再生歯科治療学])
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[継承]
2.細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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学籍番号 (推奨):
[継承]
3. (英) Komatsuzawa H (日) (読)
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学籍番号 (推奨):
[継承]
4. (英) Goncalves RB (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Karimbux N (日) (読)
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学籍番号 (推奨):
[継承]
6. (英) Napimoga MH (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7.関 誠 ([三菱ウェルファーマ 株式会社])
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学籍番号 (推奨):
[継承]
8. (英) Ouhara K (日) (読)
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学籍番号 (推奨):
[継承]
9. (英) Sugai M (日) (読)
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学籍番号 (推奨):
[継承]
10.Taubman Martin ([The Forsyth Institute, Department of Immunology])
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学籍番号 (推奨):
[継承]
11.河井 敬久 ([The Forsyth Institute, Department of Immunology])
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貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Anti-microbial peptides produced from mucosal epithelium appear to play pivotal roles in the host innate immune defence system in the oral cavity. In particular, human beta-defensins (hBDs) and the cathelicidin-type anti-microbial peptide, LL-37, were reported to kill periodontal disease-associated bacteria. In contrast to well-studied hBDs, little is known about the expression profiles of LL-37 in gingival tissue. In this study, the anti-microbial peptides expressed in gingival tissue were analysed using immunohistochemistry and enxyme-linked immunosorbent assay (ELISA). Immunohistochemistry revealed that neutrophils expressed only LL-37, but not hBD-2 or hBD-3, and that such expression was prominent in the inflammatory lesions when compared to healthy gingivae which showed very few or no LL-37 expressing neutrophils. Gingival epithelial cells (GEC), however, expressed all three examined anti-microbial peptides, irrespective of the presence or absence of inflammation. Moreover, as determined by ELISA, the concentration of LL-37 in the gingival tissue homogenates determined was correlated positively with the depth of the gingival crevice. Stimulation with periodontal bacteria in vitro induced both hBD-2 and LL-37 expressions by GEC, whereas peripheral blood neutrophils produced only LL-37 production, but not hBD-2, in response to the bacterial stimulation. These findings suggest that LL-37 displays distinct expression patterns from those of hBDs in gingival tissue.  (日)    [継承]
キーワード (推奨): 1. (英) Adult (日) (読) [継承]
2. (英) Aged (日) (読) [継承]
3. (英) Antigens, Bacterial (日) (読) [継承]
4. (英) Antimicrobial Cationic Peptides (日) (読) [継承]
5. (英) Bacteria (日) (読) [継承]
6. (英) Cells, Cultured (日) (読) [継承]
7. (英) Enzyme-Linked Immunosorbent Assay (日) (読) [継承]
8. (英) Female (日) (読) [継承]
9. (英) Gene Expression Regulation (日) (読) [継承]
10. (英) Gingiva (日) (読) [継承]
11. (英) Gingivitis (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13. (英) Immunoenzyme Techniques (日) (読) [継承]
14. (英) Male (日) (読) [継承]
15. (英) Middle Aged (日) (読) [継承]
16. (英) Neutrophils (日) (読) [継承]
17. (英) RNA, Messenger (日) (読) [継承]
18. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
19. (英) beta-Defensins (日) (読) [継承]
発行所 (推奨): Blackwell Publishing Ltd [継承]
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 0009-9104
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin Exp Immunol
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 146 [継承]
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(必須): 218 225 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 11月 初日 (平成 18年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2249.2006.03200.x    (→Scopusで検索) [継承]
PMID (任意): 17034573    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Immunology, The Forsyth Institute, Boston, Massachusetts, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) OtherID: PMC1942065  (日)    [継承]

標準的な表示

和文冊子 ● Ikuko Hosokawa, Yoshitaka Hosokawa, H Komatsuzawa, RB Goncalves, N Karimbux, MH Napimoga, Makoto Seki, K Ouhara, M Sugai, Martin A Taubman and Toshihisa Kawai : Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue., Clinical and Experimental Immunology, Vol.146, No.2, 218-225, 2006.
欧文冊子 ● Ikuko Hosokawa, Yoshitaka Hosokawa, H Komatsuzawa, RB Goncalves, N Karimbux, MH Napimoga, Makoto Seki, K Ouhara, M Sugai, Martin A Taubman and Toshihisa Kawai : Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue., Clinical and Experimental Immunology, Vol.146, No.2, 218-225, 2006.

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