○種別 (必須): | □ | 学術論文 (審査論文)
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○言語 (必須): | □ | 英語
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○招待 (推奨): |
○審査 (推奨): | □ | Peer Review
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○カテゴリ (推奨): | □ | 研究
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○共著種別 (推奨): |
○学究種別 (推奨): |
○組織 (推奨): | 1. | The Forsyth Institute, Department of Immunology
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○著者 (必須): | 1. | 細川 育子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学])
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| 2. | 細川 義隆 ([徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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| 3. | (英) Komatsuzawa H (日) (読)
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| 4. | (英) Goncalves RB (日) (読)
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| 5. | (英) Karimbux N (日) (読)
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| 6. | (英) Napimoga MH (日) (読)
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| 7. | 関 誠 ([三菱ウェルファーマ 株式会社])
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| 8. | (英) Ouhara K (日) (読)
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| 9. | (英) Sugai M (日) (読)
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| 10. | Taubman Martin ([The Forsyth Institute, Department of Immunology])
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| 11. | 河井 敬久 ([The Forsyth Institute, Department of Immunology])
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○題名 (必須): | □ | (英) Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue. (日)
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○副題 (任意): |
○要約 (任意): | □ | (英) Anti-microbial peptides produced from mucosal epithelium appear to play pivotal roles in the host innate immune defence system in the oral cavity. In particular, human beta-defensins (hBDs) and the cathelicidin-type anti-microbial peptide, LL-37, were reported to kill periodontal disease-associated bacteria. In contrast to well-studied hBDs, little is known about the expression profiles of LL-37 in gingival tissue. In this study, the anti-microbial peptides expressed in gingival tissue were analysed using immunohistochemistry and enxyme-linked immunosorbent assay (ELISA). Immunohistochemistry revealed that neutrophils expressed only LL-37, but not hBD-2 or hBD-3, and that such expression was prominent in the inflammatory lesions when compared to healthy gingivae which showed very few or no LL-37 expressing neutrophils. Gingival epithelial cells (GEC), however, expressed all three examined anti-microbial peptides, irrespective of the presence or absence of inflammation. Moreover, as determined by ELISA, the concentration of LL-37 in the gingival tissue homogenates determined was correlated positively with the depth of the gingival crevice. Stimulation with periodontal bacteria in vitro induced both hBD-2 and LL-37 expressions by GEC, whereas peripheral blood neutrophils produced only LL-37 production, but not hBD-2, in response to the bacterial stimulation. These findings suggest that LL-37 displays distinct expression patterns from those of hBDs in gingival tissue. (日)
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○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Antigens, Bacterial (日) (読)
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| 4. | (英) Antimicrobial Cationic Peptides (日) (読)
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| 5. | (英) Bacteria (日) (読)
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| 6. | (英) Cells, Cultured (日) (読)
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| 7. | (英) Enzyme-Linked Immunosorbent Assay (日) (読)
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| 8. | (英) Female (日) (読)
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| 9. | (英) Gene Expression Regulation (日) (読)
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| 10. | (英) Gingiva (日) (読)
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| 11. | (英) Gingivitis (日) (読)
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| 12. | (英) Humans (日) (読)
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| 13. | (英) Immunoenzyme Techniques (日) (読)
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| 14. | (英) Male (日) (読)
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| 15. | (英) Middle Aged (日) (読)
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| 16. | (英) Neutrophils (日) (読)
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| 17. | (英) RNA, Messenger (日) (読)
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| 18. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 19. | (英) beta-Defensins (日) (読)
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○発行所 (推奨): | □ | Blackwell Publishing Ltd
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○誌名 (必須): | □ | Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)
○ISSN (任意): | □ | 0009-9104
ISSN: 0009-9104
(pISSN: 0009-9104, eISSN: 1365-2249) Title: Clinical and experimental immunologyTitle(ISO): Clin Exp ImmunolSupplier: British Society for ImmunologyPublisher: Wiley Publishing (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
(Scopus information is found. [need login])
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○巻 (必須): | □ | 146
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○号 (必須): | □ | 2
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○頁 (必須): | □ | 218 225
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○年月日 (必須): | □ | 西暦 2006年 11月 初日 (平成 18年 11月 初日)
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○URL (任意): |
○DOI (任意): | □ | 10.1111/j.1365-2249.2006.03200.x (→Scopusで検索)
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○PMID (任意): | □ | 17034573 (→Scopusで検索)
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○備考 (任意): | 1. | (英) Article.Affiliation: Department of Immunology, The Forsyth Institute, Boston, Massachusetts, USA. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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| 4. | (英) OtherID: PMC1942065 (日)
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