『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=164166)

EID=164166EID:164166, Map:0, LastModified:2020年7月31日(金) 14:41:22, Operator:[石田 竜弘], Avail:TRUE, Censor:0, Owner:[石田 竜弘], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.石田 竜弘 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.薬物動態制御学]/[徳島大学.大学院医歯薬学研究部.薬学域.連携研究部門(薬学域).寄附講座系(薬学域).がん細胞と代謝学]/[徳島大学.大学産業院])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Okada Yurie (日) 岡田 百合絵 (読) おかだ ゆりえ
役割 (任意):
貢献度 (任意):
学籍番号 (推奨): **** [ユーザ]
[継承]
3. (英) Kobayashi Tomotaka (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.際田 弘志
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood.  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have reported that targeted, pH-sensitive sterically stabilized liposomes are able to increase the cytotoxicity of DXR in vitro against B lymphoma cells, but the rate of release of DXR in plasma was too rapid to permit the results to be extended to in vivo applications. The purpose of the study reported here is two-fold. First, to understand the mechanism of the rapid release of DXR from pH-sensitive sterically stabilized liposomes (PSL) in human plasma. Second, to reformulate the above liposomes to improve their drug retention, while retaining their pH sensitivity. The stability of the PSL formulations in human plasma was evaluated by comparing the rate of release of encapsulated DXR with that of HPTS, a water-soluble fluorescent marker. Since DXR, but not HPTS, a water soluble-less membrane permeable fluorescence marker, was rapidly released from liposomes in the presence of plasma, the rapid release of DXR is likely caused by the diffusion of DXR molecules through the lipid bilayer, not by the disruption of the membrane. In order to develop more stable PSL formulations, various molar ratios of the membrane rigidifying lipid, hydrogenated soy HSPC and/or CHOL, were added to the lipid composition and the rate of release of encapsulated solutes and pH-sensitivity were evaluated. The compositions that showed the best drug retention and pH-sensitivity were a mixture of DOPE/HSPC/CHEMS/CHOL/mPEG(2000)-DSPE at a molar ratio of 4:2:2:2:0.3 and DOPE/HSPC/CHEMS/CHOL at a molar ratio of 4:2:2:2. Our formulations, if targeted to internalizing antigens on cancer cells, may increase intracellular drug release rates within acidic compartment, resulting in a further increase in the therapeutic efficacy of targeted anticancer drug-containing liposomes.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antibiotics, Antineoplastic (日) (読) [継承]
3.コレステロール (cholesterol) [継承]
4.拡散 (diffusion) [継承]
5. (英) Doxorubicin (日) (読) [継承]
6. (英) Hydrogen-Ion Concentration (日) (読) [継承]
7. (英) Lipids (日) (読) [継承]
8.リポソーム (liposomes) [継承]
9. (英) Male (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11.分子量 (molecular weight) [継承]
12. (英) Phosphatidylcholines (日) (読) [継承]
13. (英) Phosphatidylethanolamines (日) (読) [継承]
14.プラズマ (plasma) [継承]
15. (英) Polyethylene Glycols (日) (読) [継承]
16.溶解度 (solubility) [継承]
17. (英) Technology, Pharmaceutical (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Pharmaceutics (Elsevier B.V.)
(pISSN: 0378-5173, eISSN: 1873-3476)

ISSN (任意): 0378-5173
ISSN: 0378-5173 (pISSN: 0378-5173, eISSN: 1873-3476)
Title: International journal of pharmaceutics
Title(ISO): Int J Pharm
Publisher: Elsevier B.V.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 309 [継承]
(必須): 1-2 [継承]
(必須): 94 100 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 2月 初日 (平成 18年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/j.ijpharm.2005.11.010    (→Scopusで検索) [継承]
PMID (任意): 16364578    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意): 000235571400013 [継承]
Scopus (任意): 2-s2.0-31144443980 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacokinetics and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan. ishida@ph.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tatsuhiro Ishida, Yurie Okada, Tomotaka Kobayashi and Hiroshi Kiwada : Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood., International Journal of Pharmaceutics, Vol.309, No.1-2, 94-100, 2006.
欧文冊子 ● Tatsuhiro Ishida, Yurie Okada, Tomotaka Kobayashi and Hiroshi Kiwada : Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood., International Journal of Pharmaceutics, Vol.309, No.1-2, 94-100, 2006.

関連情報

Number of session users = 0, LA = 0.24, Max(EID) = 405196, Max(EOID) = 1098795.