『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Murakami Shinsuke (日) (読)
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2. (英) Nagaya Noritoshi (日) (読)
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3. (英) Itoh Takefumi (日) (読)
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[継承]
4. (英) Kataoka Masaharu (日) (読)
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5.岩瀬 俊
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6. (英) Horio Takeshi (日) (読)
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7. (英) Miyahara Yoshinori (日) (読)
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8. (英) Sakai Yoshiki (日) (読)
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9.寒川 賢治 (国立循環器病センター研究所)
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10. (英) Kimura Hiroshi (日) (読)
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題名 (必須): (英) Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) The balance between prostacyclin and thromboxane A2 (TXA2) plays an important role in pulmonary homeostasis. However, little information is available regarding the therapeutic potency of these prostanoids for pulmonary fibrosis. We have recently developed ONO-1301, a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity. Thus we investigated whether repeated administration of ONO-1301 attenuates bleomycin-induced pulmonary fibrosis in mice. After intratracheal injection of bleomycin or saline, mice were randomized to receive repeated subcutaneous administration of ONO-1301 or vehicle. Bronchoalveolar lavage (BAL) and histological analyses were performed at 3, 7, and 14 days after bleomycin injection. In vitro studies using mouse lung fibroblasts were also performed. ONO-1301 significantly attenuated the development of bleomycin-induced pulmonary fibrosis, as indicated by significant decreases in Ashcroft score and lung hydroxyproline content. ONO-1301 significantly reduced total cell count, neutrophil count, and total protein level in BAL fluid in association with a marked reduction of TXB2. A single administration of ONO-1301 significantly increased plasma cAMP level for >2 h. In vitro, ONO-1301 and a cAMP analog dose-dependently reduced cell proliferation in mouse lung fibroblasts. The reduction in cell proliferation by ONO-1301 was attenuated by a protein kinase A (PKA) inhibitor. Furthermore, bleomycin mice treated with ONO-1301 had a significantly higher survival rate than those given vehicle. These results suggest that repeated administration of ONO-1301 attenuates the development of bleomycin-induced pulmonary fibrosis and improves survival in bleomycin mice, at least in part by inhibition of TXA2 synthesis and activation of the cAMP/PKA pathway.  (日)    [継承]
キーワード (推奨): 1. (英) adenosine 3',5'-cyclic monophosphate (日) (読) [継承]
2. (英) fibroblast (日) (読) [継承]
3. (英) neutrophil (日) (読) [継承]
4.線量生存率曲線 (dose-survival curve) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Physiology. Lung Cellular and Molecular Physiology ([アメリカ生理学会])
(pISSN: 1040-0605, eISSN: 1522-1504)

ISSN (任意): 1040-0605
ISSN: 1040-0605 (pISSN: 1040-0605, eISSN: 1522-1504)
Title: American journal of physiology. Lung cellular and molecular physiology
Title(ISO): Am J Physiol Lung Cell Mol Physiol
Publisher: American Physiological Society
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(必須): 290 [継承]
(必須): 1 [継承]
(必須): L59 L65 [継承]
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年月日 (必須): 西暦 2006年 1月 初日 (平成 18年 1月 初日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16155090 [継承]
DOI (任意): 10.1152/ajplung.00042.2005    (→Scopusで検索) [継承]
PMID (任意): 16155090    (→Scopusで検索) [継承]
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WOS (任意): 000233897700008 [継承]
Scopus (任意): 2-s2.0-33644750037 [継承]
評価値 (任意):
被引用数 (任意): 2 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shinsuke Murakami, Noritoshi Nagaya, Takefumi Itoh, Masaharu Kataoka, Takashi Iwase, Takeshi Horio, Yoshinori Miyahara, Yoshiki Sakai, Kenji Kangawa and Hiroshi Kimura : Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice, American Journal of Physiology. Lung Cellular and Molecular Physiology, Vol.290, No.1, L59-L65, 2006.
欧文冊子 ● Shinsuke Murakami, Noritoshi Nagaya, Takefumi Itoh, Masaharu Kataoka, Takashi Iwase, Takeshi Horio, Yoshinori Miyahara, Yoshiki Sakai, Kenji Kangawa and Hiroshi Kimura : Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice, American Journal of Physiology. Lung Cellular and Molecular Physiology, Vol.290, No.1, L59-L65, 2006.

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