『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Nagaya Noritoshi (日) (読)
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[継承]
2.寒川 賢治 (国立循環器病センター研究所)
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[継承]
3. (英) Itoh Takefumi (日) (読)
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4.岩瀬 俊
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5. (英) Murakami Shinsuke (日) (読)
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6. (英) Miyahara Yoshinori (日) (読)
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7. (英) Fujii Takafumi (日) (読)
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8. (英) Uematsu Masaaki (日) (読)
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9. (英) Ohgushi Hajime (日) (読)
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10. (英) Yamagishi Masakazu (日) (読)
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11. (英) Tokudome Takeshi (日) (読)
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12. (英) Mori Hidezo (日) (読)
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13. (英) Miyatake Kunio (日) (読)
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14. (英) Kitamura Soichiro (日) (読)
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題名 (必須): (英) Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy  (日)    [継承]
副題 (任意):
要約 (任意): (英) BACKGROUND: Pluripotent mesenchymal stem cells (MSCs) differentiate into a variety of cells, including cardiomyocytes and vascular endothelial cells. However, little information is available about the therapeutic potency of MSC transplantation in cases of dilated cardiomyopathy (DCM), an important cause of heart failure. METHODS AND RESULTS: We investigated whether transplanted MSCs induce myogenesis and angiogenesis and improve cardiac function in a rat model of DCM. MSCs were isolated from bone marrow aspirates of isogenic adult rats and expanded ex vivo. Cultured MSCs secreted large amounts of the angiogenic, antiapoptotic, and mitogenic factors vascular endothelial growth factor, hepatocyte growth factor, adrenomedullin, and insulin-like growth factor-1. Five weeks after immunization, MSCs or vehicle was injected into the myocardium. Some engrafted MSCs were positive for the cardiac markers desmin, cardiac troponin T, and connexin-43, whereas others formed vascular structures and were positive for von Willebrand factor or smooth muscle actin. Compared with vehicle injection, MSC transplantation significantly increased capillary density and decreased the collagen volume fraction in the myocardium, resulting in decreased left ventricular end-diastolic pressure (11+/-1 versus 16+/-1 mm Hg, P<0.05) and increased left ventricular maximum dP/dt (6767+/-323 versus 5138+/-280 mm Hg/s, P<0.05). CONCLUSIONS: MSC transplantation improved cardiac function in a rat model of DCM, possibly through induction of myogenesis and angiogenesis, as well as by inhibition of myocardial fibrosis. The beneficial effects of MSCs might be mediated not only by their differentiation into cardiomyocytes and vascular cells but also by their ability to supply large amounts of angiogenic, antiapoptotic, and mitogenic factors.  (日)    [継承]
キーワード (推奨): 1. (英) myocytes (日) (読) [継承]
2.血管新生 (angiogenesis) [継承]
3.心不全 (heart failure) [継承]
4. (英) growth substances (日) (読) [継承]
5. (英) transplantation (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Circulation ([American Heart Association])
(pISSN: 0009-7322, eISSN: 1524-4539)

ISSN (任意): 1524-4539
ISSN: 0009-7322 (pISSN: 0009-7322, eISSN: 1524-4539)
Title: Circulation
Title(ISO): Circulation
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 112 [継承]
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(必須): 1128 1135 [継承]
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年月日 (必須): 西暦 2005年 8月 23日 (平成 17年 8月 23日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16103243 [継承]
DOI (任意): 10.1161/CIRCULATIONAHA.104.500447    (→Scopusで検索) [継承]
PMID (任意): 16103243    (→Scopusで検索) [継承]
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WOS (任意): 000231371300012 [継承]
Scopus (任意): 2-s2.0-24044535092 [継承]
評価値 (任意):
被引用数 (任意): 7 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan. nnagaya@ri.ncvc.go.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Noritoshi Nagaya, Kenji Kangawa, Takefumi Itoh, Takashi Iwase, Shinsuke Murakami, Yoshinori Miyahara, Takafumi Fujii, Masaaki Uematsu, Hajime Ohgushi, Masakazu Yamagishi, Takeshi Tokudome, Hidezo Mori, Kunio Miyatake and Soichiro Kitamura : Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy, Circulation, Vol.112, No.8, 1128-1135, 2005.
欧文冊子 ● Noritoshi Nagaya, Kenji Kangawa, Takefumi Itoh, Takashi Iwase, Shinsuke Murakami, Yoshinori Miyahara, Takafumi Fujii, Masaaki Uematsu, Hajime Ohgushi, Masakazu Yamagishi, Takeshi Tokudome, Hidezo Mori, Kunio Miyatake and Soichiro Kitamura : Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy, Circulation, Vol.112, No.8, 1128-1135, 2005.

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