『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Murakami Shinsuke (日) (読)
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[継承]
2. (英) Nagaya Noritoshi (日) (読)
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[継承]
3. (英) Itoh Takefumi (日) (読)
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[継承]
4.岩瀬 俊
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[継承]
5. (英) Fujisato Toshiya (日) (読)
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[継承]
6. (英) Nishioka Keisuke (日) (読)
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[継承]
7. (英) Hamada Kaoru (日) (読)
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[継承]
8.寒川 賢治 (国立循環器病センター研究所)
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学籍番号 (推奨):
[継承]
9. (英) Kimura Hiroshi (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Adrenomedullin Regenerates Alveoli and Vasculature in Elastase-induced Pulmonary Emphysema in Mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) RATIONALE: Adrenomedullin, a potent vasodilator peptide, regulates cell growth and survival. However, whether adrenomedullin contributes to lung regeneration remains unknown. OBJECTIVES: To investigate whether adrenomedullin influences the kinetics of bone marrow cells, and whether adrenomedullin promotes regeneration of alveoli and vasculature and thereby improves lung structure and function in elastase-induced emphysema in mice. METHODS: Adrenomedullin or vehicle was randomly administered to C57BL/6 mice for 5 days. We counted the numbers of mononuclear cells and stem cell antigen-1-positive cells in circulating blood. After intratracheal injection of elastase or saline, mice were randomized to receive continuous infusion of adrenomedullin or vehicle for 14 days. Functional and histologic analyses were performed 28 days after treatment. RESULTS: Twenty-eight days after elastase injection, destruction of the alveolar walls was observed. However, adrenomedullin infusion significantly inhibited the increase in lung volume, static lung compliance, and mean linear intercept in mice given elastase. Adrenomedullin increased the numbers of mononuclear cells and stem cell antigen-1-positive cells in circulating blood. Adrenomedullin significantly increased the number of bone marrow-derived cells incorporated into the elastase-treated lung. Some of these cells were positive for cytokeratin or von Willebrand factor. Infusion of adrenomedullin after the establishment of emphysema also had beneficial effects on lung structure and function. In vitro, addition of adrenomedullin attenuates elastase-induced cell death in alveolar epithelial cells and endothelial cells. CONCLUSIONS: Adrenomedullin improved elastase-induced emphysema at least in part through mobilization of bone marrow cells and the direct protective effects on alveolar epithelial cells and endothelial cells.  (日)    [継承]
キーワード (推奨): 1. (英) bone marrow cells (日) (読) [継承]
2.細胞増殖·分化 (cell proliferation and differentiation) [継承]
3. (英) mobilization (日) (読) [継承]
4. (英) regeneration (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Respiratory and Critical Care Medicine (American Thoracic Society/American Lung Association)
(pISSN: 1073-449X, eISSN: 1535-4970)

ISSN (任意): 1073-449X
ISSN: 1073-449X (pISSN: 1073-449X, eISSN: 1535-4970)
Title: American journal of respiratory and critical care medicine
Title(ISO): Am J Respir Crit Care Med
Publisher: American Thoracic Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 172 [継承]
(必須): 5 [継承]
(必須): 581 589 [継承]
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年月日 (必須): 西暦 2005年 9月 1日 (平成 17年 9月 1日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15947283 [継承]
DOI (任意): 10.1164/rccm.200409-1280OC    (→Scopusで検索) [継承]
PMID (任意): 15947283    (→Scopusで検索) [継承]
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WOS (任意): 000231574500011 [継承]
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評価値 (任意):
被引用数 (任意): 7 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Evaluation Studies  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shinsuke Murakami, Noritoshi Nagaya, Takefumi Itoh, Takashi Iwase, Toshiya Fujisato, Keisuke Nishioka, Kaoru Hamada, Kenji Kangawa and Hiroshi Kimura : Adrenomedullin Regenerates Alveoli and Vasculature in Elastase-induced Pulmonary Emphysema in Mice, American Journal of Respiratory and Critical Care Medicine, Vol.172, No.5, 581-589, 2005.
欧文冊子 ● Shinsuke Murakami, Noritoshi Nagaya, Takefumi Itoh, Takashi Iwase, Toshiya Fujisato, Keisuke Nishioka, Kaoru Hamada, Kenji Kangawa and Hiroshi Kimura : Adrenomedullin Regenerates Alveoli and Vasculature in Elastase-induced Pulmonary Emphysema in Mice, American Journal of Respiratory and Critical Care Medicine, Vol.172, No.5, 581-589, 2005.

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