『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kataoka Masaharu (日) (読)
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[継承]
2. (英) Satoh Toru (日) (読)
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[継承]
3. (英) Itoh Takefumi (日) (読)
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[継承]
4. (英) Murakami Shinsuke (日) (読)
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5.岩瀬 俊
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6. (英) Miyahara Yoshinori (日) (読)
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7. (英) Kyotani Shingo (日) (読)
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8. (英) Sakai Yoshiki (日) (読)
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9.寒川 賢治 (国立循環器病センター研究所)
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10. (英) Ogawa Satoshi (日) (読)
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題名 (必須): (英) A Long-Acting Prostacyclin Agonist with Thromboxane Inhibitory Activity for Pulmonary Hypertension  (日)    [継承]
副題 (任意):
要約 (任意): (英) Rationale: The balance between prostacyclin and thromboxane plays an important role in the regulation of pulmonary vascular tone. Recently, we developed ONO-1301, a novel, long-acting prostacyclin agonist with thromboxane synthase inhibitory activity. Objectives: We investigated whether modulation of prostacyclin/thromboxane balance by ONO-1301 ameliorates monocrotaline-induced pulmonary hypertension in rats. Methods: After subcutaneous injection of monocrotaline or vehicle, rats were randomized to receive repeated subcutaneous administration of ONO-1301 or vehicle twice per day for 3 wk. Measurements and Main Results: There was significant development of pulmonary hypertension 3 wk after monocrotaline injection. Treatment with ONO-1301 significantly attenuated the increases in right ventricular systolic pressure and ratio of right ventricular weight to body weight in monocrotaline rats. Furthermore, ONO-1301 significantly attenuated the increase in medial wall thickness of peripheral pulmonary arteries in monocrotaline rats. The half-life of plasma ONO-1301 concentration after a single subcutaneous administration was approximately 5.6 h. A single administration of ONO-1301 increased plasma cyclic adenosine 3', 5'-monophosphate level, which lasted at least up to 8 h. Treatment with ONO-1301 significantly decreased plasma 11-dehydro-thromboxane B2, a metabolite of thromboxane, in monocrotaline rats. Finally, Kaplan-Meier survival curves demonstrated that repeated administration of ONO-1301 improved survival rate in monocrotaline rats compared with vehicle administration (80 vs. 30% in 6-wk survival). Conclusions: Subcutaneous administration of a novel prostacyclin agonist (ONO-1301) markedly attenuated monocrotaline-induced pulmonary hypertension and improved survival in rats. The beneficial effects of ONO-1301 may occur through its long-lasting stimulation of cyclic adenosine 3', 5'-monophosphate and inhibition of thromboxane synthase.  (日)    [継承]
キーワード (推奨): 1. (英) cAMP (日) (読) [継承]
2. (英) monocrotaline (日) (読) [継承]
3. (英) hemodynamics (日) (読) [継承]
4. (英) vascular remodeling (日) (読) [継承]
発行所 (推奨):
誌名 (必須): American Journal of Respiratory and Critical Care Medicine (American Thoracic Society/American Lung Association)
(pISSN: 1073-449X, eISSN: 1535-4970)

ISSN (任意): 1073-449X
ISSN: 1073-449X (pISSN: 1073-449X, eISSN: 1535-4970)
Title: American journal of respiratory and critical care medicine
Title(ISO): Am J Respir Crit Care Med
Publisher: American Thoracic Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 172 [継承]
(必須): 12 [継承]
(必須): 1575 1580 [継承]
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年月日 (必須): 西暦 2005年 12月 5日 (平成 17年 12月 5日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16192456 [継承]
DOI (任意): 10.1164/rccm.200501-102OC    (→Scopusで検索) [継承]
PMID (任意): 16192456    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意): 000234019000019 [継承]
Scopus (任意): 2-s2.0-30444453849 [継承]
評価値 (任意):
被引用数 (任意): 1 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Masaharu Kataoka, Toru Satoh, Takefumi Itoh, Shinsuke Murakami, Takashi Iwase, Yoshinori Miyahara, Shingo Kyotani, Yoshiki Sakai, Kenji Kangawa and Satoshi Ogawa : A Long-Acting Prostacyclin Agonist with Thromboxane Inhibitory Activity for Pulmonary Hypertension, American Journal of Respiratory and Critical Care Medicine, Vol.172, No.12, 1575-1580, 2005.
欧文冊子 ● Masaharu Kataoka, Toru Satoh, Takefumi Itoh, Shinsuke Murakami, Takashi Iwase, Yoshinori Miyahara, Shingo Kyotani, Yoshiki Sakai, Kenji Kangawa and Satoshi Ogawa : A Long-Acting Prostacyclin Agonist with Thromboxane Inhibitory Activity for Pulmonary Hypertension, American Journal of Respiratory and Critical Care Medicine, Vol.172, No.12, 1575-1580, 2005.

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