『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=163817EID:163817, Map:0, LastModified:2012年10月18日(木) 11:43:03, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[湯本 浩通], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.湯本 浩通 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯周歯内治療学])
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[継承]
2. (英) Yamada Masayoshi (日) (読)
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[継承]
3.篠原 千尋
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[継承]
4.中江 英明
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[継承]
5.高橋 加奈子
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[継承]
6. (英) Azakami Hiroyuki (日) (読)
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7. (英) Shigeyuki Ebisu (日) (読)
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[継承]
8.松尾 敬志
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Soluble products from Eikenella corrodens induce cell proliferation and expression of interleukin-8 and adhesion molecules in endothelial cells via mitogen-activated protein kinase pathways  (日)    [継承]
副題 (任意):
要約 (任意): (英) The periodontal vasculature is profoundly affected during the progression of periodontitis, and several specific bacteria are believed to be involved in this inflammatory disease. Eikenella corrodens is one of the common bacteria detected in periodontitis diseased lesions; however, the function of this organism in periodontitis is not well understood. In this study, we investigated the E. corrodens-induced endothelial cell alteration and inflammation process that leads to leukocyte infiltration in inflamed regions. Soluble products from E. corrodens (EcSP) induced the gene expression and protein production of vascular endothelial growth factor in oral epithelial cells and human umbilical vein endothelial cells (HUVEC). Direct stimulation by EcSP also activated endothelial cell proliferation. Moreover, EcSP induced ERK1/2 (p44/42) and p38 mitogen-activated protein kinase (MAPK) phosphorylation within 10-30 min in HUVEC, as demonstrated by Western blot analysis and up-regulated intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin and interleukin-8 (IL-8) production demonstrated by reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay. The specific p38 MAPK inhibitor SB203580 reduced the expression of ICAM-1, VCAM-1 and IL-8, whereas the blockade of p44/42 by MAPK kinase (MEK1) inhibitor, PD98059, inhibited only IL-8 expression. Our results indicate that E. corrodens can trigger a cascade of events that induce inflammatory responses in periodontal tissue via the MAPK cascade and may promote chronic periodontitis without bacteria-cell contact.  (日)    [継承]
キーワード (推奨): 1. (英) Cell Adhesion Molecules (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) Cell Proliferation (日) (読) [継承]
4. (英) Cells, Cultured (日) (読) [継承]
5. (英) Culture Media, Conditioned (日) (読) [継承]
6. (英) E-Selectin (日) (読) [継承]
7. (英) Eikenella corrodens (日) (読) [継承]
8. (英) Endothelial Cells (日) (読) [継承]
9. (英) Endothelium, Vascular (日) (読) [継承]
10. (英) Enzyme Inhibitors (日) (読) [継承]
11. (英) Epithelial Cells (日) (読) [継承]
12. (英) Flavonoids (日) (読) [継承]
13. (英) Humans (日) (読) [継承]
14. (英) Imidazoles (日) (読) [継承]
15. (英) Intercellular Adhesion Molecule-1 (日) (読) [継承]
16. (英) Interleukin-8 (日) (読) [継承]
17. (英) KB Cells (日) (読) [継承]
18. (英) Mitogen-Activated Protein Kinase 1 (日) (読) [継承]
19. (英) Mitogen-Activated Protein Kinase 3 (日) (読) [継承]
20. (英) Mitogen-Activated Protein Kinases (日) (読) [継承]
21. (英) Periodontitis (日) (読) [継承]
22. (英) Phosphorylation (日) (読) [継承]
23. (英) Pyridines (日) (読) [継承]
24. (英) Vascular Cell Adhesion Molecule-1 (日) (読) [継承]
25. (英) Vascular Endothelial Growth Factor A (日) (読) [継承]
26. (英) p38 Mitogen-Activated Protein Kinases (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oral Microbiology and Immunology ([John Wiley & Sons, Inc.])
(pISSN: 0902-0055, eISSN: 1399-302X)

ISSN (任意): 0902-0055
ISSN: 0902-0055 (pISSN: 0902-0055, eISSN: 1399-302X)
Title: Oral microbiology and immunology
Title(ISO): Oral Microbiol Immunol
Publisher: Blackwell
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 36 45 [継承]
都市 (任意):
年月日 (必須): 西暦 2007年 2月 初日 (平成 19年 2月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1399-302X.2007.00320.x    (→Scopusで検索) [継承]
PMID (任意): 17241169    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Conservative Dentistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. yumoto@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hiromichi Yumoto, Masayoshi Yamada, Chihiro Shinohara, Hideaki Nakae, Kanako Takahashi, Hiroyuki Azakami, Ebisu Shigeyuki and Takashi Matsuo : Soluble products from Eikenella corrodens induce cell proliferation and expression of interleukin-8 and adhesion molecules in endothelial cells via mitogen-activated protein kinase pathways, Oral Microbiology and Immunology, Vol.22, No.1, 36-45, 2007.
欧文冊子 ● Hiromichi Yumoto, Masayoshi Yamada, Chihiro Shinohara, Hideaki Nakae, Kanako Takahashi, Hiroyuki Azakami, Ebisu Shigeyuki and Takashi Matsuo : Soluble products from Eikenella corrodens induce cell proliferation and expression of interleukin-8 and adhesion molecules in endothelial cells via mitogen-activated protein kinase pathways, Oral Microbiology and Immunology, Vol.22, No.1, 36-45, 2007.

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