『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.岩瀬 俊
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[継承]
2. (英) Nagaya Noritoshi (日) (読)
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[継承]
3. (英) Fujii Takafumi (日) (読)
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[継承]
4. (英) Itoh Takefumi (日) (読)
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[継承]
5. (英) Ishibashi-Ueda Hatsue (日) (読)
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[継承]
6. (英) Yamagishi Masakazu (日) (読)
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7. (英) Miyatake Kunio (日) (読)
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8.松本 俊夫
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9. (英) Kitamura Soichiro (日) (読)
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10.寒川 賢治 (国立循環器病センター研究所)
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[継承]
題名 (必須): (英) Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia  (日)    [継承]
副題 (任意):
要約 (任意): (英) BACKGROUND: Previous studies have shown that adrenomedullin (AM) inhibits vascular endothelial cell apoptosis and induces angiogenesis. We investigated whether AM enhances bone marrow cell-induced angiogenesis. METHODS AND RESULTS: Immediately after hindlimb ischemia was created, rats were randomized to receive AM infusion plus bone marrow-derived mononuclear cell (MNC) transplantation (AM+MNC group), AM infusion alone (AM group), MNC transplantation alone (MNC group), or vehicle infusion (control group). The laser Doppler perfusion index was significantly higher in the AM and MNC groups than in the control group (0.74+/-0.11 and 0.69+/-0.07 versus 0.59+/-0.07, respectively, P<0.01), which suggests the angiogenic potency of AM and MNC. Importantly, improvement in blood perfusion was marked in the AM+MNC group (0.84+/-0.08). Capillary density was highest in the AM+MNC group, followed by the AM and MNC groups. In vitro, AM inhibited MNC apoptosis, promoted MNC adhesiveness to a human umbilical vein endothelial cell monolayer, and increased the number of MNC-derived endothelial progenitor cells. In vivo, AM administration not only enhanced the differentiation of MNC into endothelial cells but also produced mature vessels that included smooth muscle cells. CONCLUSIONS: A combination of AM infusion and MNC transplantation caused significantly greater improvement in hindlimb ischemia than MNC transplantation alone. This effect may be mediated in part by the angiogenic potency of AM itself and the beneficial effects of AM on the survival, adhesion, and differentiation of transplanted MNCs.  (日)    [継承]
キーワード (推奨): 1. (英) Adrenomedullin (日) (読) [継承]
2. (英) Angiogenesis Inducing Agents (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4.アポトーシス (apoptosis) [継承]
5. (英) Bone Marrow Transplantation (日) (読) [継承]
6. (英) Cell Adhesion (日) (読) [継承]
7.細胞分化 (cell differentiation) [継承]
8. (英) Cell Movement (日) (読) [継承]
9. (英) Cells, Cultured (日) (読) [継承]
10. (英) Combined Modality Therapy (日) (読) [継承]
11. (英) Endothelial Cells (日) (読) [継承]
12. (英) Hindlimb (日) (読) [継承]
13. (英) Humans (日) (読) [継承]
14.虚血 (ischemia) [継承]
15. (英) Male (日) (読) [継承]
16. (英) Myocytes, Smooth Muscle (日) (読) [継承]
17. (英) Neovascularization, Physiologic (日) (読) [継承]
18. (英) Peptides (日) (読) [継承]
19. (英) Peripheral Vascular Diseases (日) (読) [継承]
20. (英) Random Allocation (日) (読) [継承]
21. (英) Rats (日) (読) [継承]
22. (英) Rats, Inbred Lew (日) (読) [継承]
23. (英) Stem Cells (日) (読) [継承]
24. (英) Umbilical Veins (日) (読) [継承]
25. (英) Vasodilator Agents (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Circulation ([American Heart Association])
(pISSN: 0009-7322, eISSN: 1524-4539)

ISSN (任意): 1524-4539
ISSN: 0009-7322 (pISSN: 0009-7322, eISSN: 1524-4539)
Title: Circulation
Title(ISO): Circulation
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 111 [継承]
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(必須): 356 362 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 1月 25日 (平成 17年 1月 25日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15655128 [継承]
DOI (任意): 10.1161/01.CIR.0000153352.29335.B9    (→Scopusで検索) [継承]
PMID (任意): 15655128    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意): 000226501200019 [継承]
Scopus (任意): 2-s2.0-19944431981 [継承]
評価値 (任意):
被引用数 (任意): 9 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Iwase, Noritoshi Nagaya, Takafumi Fujii, Takefumi Itoh, Hatsue Ishibashi-Ueda, Masakazu Yamagishi, Kunio Miyatake, Toshio Matsumoto, Soichiro Kitamura and Kenji Kangawa : Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia, Circulation, Vol.111, No.3, 356-362, 2005.
欧文冊子 ● Takashi Iwase, Noritoshi Nagaya, Takafumi Fujii, Takefumi Itoh, Hatsue Ishibashi-Ueda, Masakazu Yamagishi, Kunio Miyatake, Toshio Matsumoto, Soichiro Kitamura and Kenji Kangawa : Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia, Circulation, Vol.111, No.3, 356-362, 2005.

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