『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.岩瀬 俊
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[継承]
2. (英) Nagaya Noritoshi (日) (読)
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学籍番号 (推奨):
[継承]
3. (英) Fujii Takafumi (日) (読)
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[継承]
4. (英) Itoh Takefumi (日) (読)
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学籍番号 (推奨):
[継承]
5. (英) Murakami Shinsuke (日) (読)
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学籍番号 (推奨):
[継承]
6.松本 俊夫
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[継承]
7.寒川 賢治 (国立循環器病センター研究所)
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学籍番号 (推奨):
[継承]
8. (英) Kitamura Soichiro (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia  (日)    [継承]
副題 (任意):
要約 (任意): (英) OBJECTIVE: Mesenchymal stem cells (MSC) are pluripotent cells that differentiate into a variety of cells including endothelial cells and vascular smooth muscle cells. Although transplantation of bone marrow-derived mononuclear cells (MNC) has already been applied for the treatment of critical limb ischemia, little information is available regarding comparison of the angiogenic potency between MSC and MNC. Accordingly, we injected equal numbers of MSC or MNC in a rat model of hindlimb ischemia and compared their therapeutic potential. METHODS AND RESULTS: Immediately after creating hindlimb ischemia, rats were randomized to receive MSC transplantation (MSC group), MNC transplantation (MNC group), or vehicle infusion (Control group). Three weeks after transplantation, the laser Doppler perfusion index was significantly higher in the MNC group than in the Control group (0.69+/-0.1 vs. 0.57+/-0.06, P<0.01). Furthermore, there was a marked improvement in blood perfusion in the MSC group (0.81+/-0.08). Capillary density was highest in the MSC group. The number of transplanted cell-derived endothelial cells was higher in the MSC group than in the MNC group. Transplanted cell-derived vascular smooth muscle cells were detected only in the MSC group. In vitro, MSC were more tolerant to apoptotic stimulus (serum starvation and hypoxia) than MNC. CONCLUSIONS: MSC transplantation caused significantly greater improvement in hindlimb ischemia than MNC transplantation. Compared with MNC, MSC survived well under an ischemic environment, and differentiated into not only endothelial cells but also vascular smooth muscle cells. Thus, MSC transplantation may be a new therapeutic strategy for the treatment of severe peripheral vascular disease.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2.アポトーシス (apoptosis) [継承]
3. (英) Bone Marrow Transplantation (日) (読) [継承]
4.細胞分化 (cell differentiation) [継承]
5. (英) Endothelial Cells (日) (読) [継承]
6. (英) Hindlimb (日) (読) [継承]
7.虚血 (ischemia) [継承]
8. (英) Laser-Doppler Flowmetry (日) (読) [継承]
9. (英) Leukocytes, Mononuclear (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Mesenchymal Stem Cell Transplantation (日) (読) [継承]
12. (英) Models, Animal (日) (読) [継承]
13. (英) Muscle, Smooth, Vascular (日) (読) [継承]
14. (英) Neovascularization, Physiologic (日) (読) [継承]
15. (英) Peripheral Vascular Diseases (日) (読) [継承]
16. (英) Random Allocation (日) (読) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Rats, Inbred Lew (日) (読) [継承]
19. (英) Transplantation, Autologous (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cardiovascular Research (European Society of Cardiology)
(pISSN: 0008-6363, eISSN: 1755-3245)

ISSN (任意): 0008-6363
ISSN: 0008-6363 (pISSN: 0008-6363, eISSN: 1755-3245)
Title: Cardiovascular research
Title(ISO): Cardiovasc Res
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 66 [継承]
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(必須): 543 551 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 6月 1日 (平成 17年 6月 1日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15914119 [継承]
DOI (任意): 10.1016/j.cardiores.2005.02.006    (→Scopusで検索) [継承]
PMID (任意): 15914119    (→Scopusで検索) [継承]
CRID (任意):
WOS (任意): 000229853100016 [継承]
Scopus (任意): 2-s2.0-19444380789 [継承]
評価値 (任意):
被引用数 (任意): 19 [継承]
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takashi Iwase, Noritoshi Nagaya, Takafumi Fujii, Takefumi Itoh, Shinsuke Murakami, Toshio Matsumoto, Kenji Kangawa and Soichiro Kitamura : Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia, Cardiovascular Research, Vol.66, No.3, 543-551, 2005.
欧文冊子 ● Takashi Iwase, Noritoshi Nagaya, Takafumi Fujii, Takefumi Itoh, Shinsuke Murakami, Toshio Matsumoto, Kenji Kangawa and Soichiro Kitamura : Comparison of angiogenic potency between mesenchymal stem cells and mononuclear cells in a rat model of hindlimb ischemia, Cardiovascular Research, Vol.66, No.3, 543-551, 2005.

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