『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Hanabusa Kenichiro (日) (読)
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[継承]
2. (英) Nagaya Noritoshi (日) (読)
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[継承]
3.岩瀬 俊
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[継承]
4. (英) Itoh Takefumi (日) (読)
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[継承]
5. (英) Murakami Shinsuke (日) (読)
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[継承]
6. (英) Shimizu Yoshito (日) (読)
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7. (英) Taki Waro (日) (読)
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[継承]
8. (英) Miyatake Kunio (日) (読)
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[継承]
9.寒川 賢治 (国立循環器病センター研究所)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Adrenomedullin Enhances Therapeutic Potency of Mesenchymal Stem Cells After Experimental Stroke in Rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) Background and Purpose Adrenomedullin (AM) induces angiogenesis and inhibits cell apoptosis through the phosphatidylinositol 3-kinase/Akt pathway. Transplantation of mesenchymal stem cells (MSCs) has been shown to improve neurological deficits after stroke in rats. We investigated whether AM enhances the therapeutic potency of MSC transplantation. Methods Male Lewis rats (n=100) were subjected to 2-hour middle cerebral artery occlusion. Immediately after reperfusion, rats were assigned randomly to receive intravenous transplantation of MSCs plus subcutaneous infusion of AM for 7 days (MSC+AM group), AM infusion alone (AM group), MSC transplantation alone (MSC group), or vehicle infusion (control group). Neurological and immunohistological assessments were performed to examine the effects of these treatments. Results Some engrafted MSCs were positive for neuronal and endothelial cell markers, although the number of differentiated MSCs did not differ significantly between the MSC and MSC+AM groups. The neurological score significantly improved in the MSC, AM, and MSC+AM groups compared with the control group. Importantly, improvement in the MSC+AM group was significantly greater than that in the MSC and AM groups. There was marked induction of angiogenesis in the ischemic penumbra in the MSC+AM group, followed by the AM, MSC, and control groups. AM infusion significantly inhibited apoptosis of transplanted MSCs. As a result, the number of engrafted MSCs in the MSC+AM group was significantly higher than that in the MSC group. Conclusions AM enhanced the therapeutic potency of MSCs, including neurological improvement, possibly through inhibition of MSC apoptosis and induction of angiogenesis.  (日)    [継承]
キーワード (推奨): 1. (英) Adrenomedullin (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3.アポトーシス (apoptosis) [継承]
4. (英) Body Weight (日) (読) [継承]
5. (英) Cell Transplantation (日) (読) [継承]
6. (英) Disease Models, Animal (日) (読) [継承]
7.免疫組織化学 (immunohistochemistry) [継承]
8. (英) In Situ Nick-End Labeling (日) (読) [継承]
9. (英) Infarction, Middle Cerebral Artery (日) (読) [継承]
10.虚血 (ischemia) [継承]
11. (英) Male (日) (読) [継承]
12. (英) Mesenchymal Stem Cell Transplantation (日) (読) [継承]
13. (英) Mesenchymal Stem Cells (日) (読) [継承]
14. (英) Neovascularization, Pathologic (日) (読) [継承]
15. (英) Neurons (日) (読) [継承]
16. (英) Peptides (日) (読) [継承]
17. (英) Phosphatidylinositol 3-Kinases (日) (読) [継承]
18. (英) Rats (日) (読) [継承]
19. (英) Rats, Inbred Lew (日) (読) [継承]
20. (英) Stem Cells (日) (読) [継承]
21. (英) Stroke (日) (読) [継承]
22. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Stroke ([American Heart Association])
(pISSN: 0039-2499, eISSN: 1524-4628)

ISSN (任意): 1524-4628
ISSN: 0039-2499 (pISSN: 0039-2499, eISSN: 1524-4628)
Title: Stroke
Title(ISO): Stroke
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2005年 4月 初日 (平成 17年 4月 初日) [継承]
URL (任意): http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15746464 [継承]
DOI (任意): 10.1161/01.STR.0000157661.69482.76    (→Scopusで検索) [継承]
PMID (任意): 15746464    (→Scopusで検索) [継承]
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WOS (任意): 000228039700035 [継承]
Scopus (任意): 2-s2.0-16844380263 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kenichiro Hanabusa, Noritoshi Nagaya, Takashi Iwase, Takefumi Itoh, Shinsuke Murakami, Yoshito Shimizu, Waro Taki, Kunio Miyatake and Kenji Kangawa : Adrenomedullin Enhances Therapeutic Potency of Mesenchymal Stem Cells After Experimental Stroke in Rats, Stroke, Vol.36, No.4, 853-858, 2005.
欧文冊子 ● Kenichiro Hanabusa, Noritoshi Nagaya, Takashi Iwase, Takefumi Itoh, Shinsuke Murakami, Yoshito Shimizu, Waro Taki, Kunio Miyatake and Kenji Kangawa : Adrenomedullin Enhances Therapeutic Potency of Mesenchymal Stem Cells After Experimental Stroke in Rats, Stroke, Vol.36, No.4, 853-858, 2005.

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