『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=163641EID:163641, Map:0, LastModified:2012年10月13日(土) 21:12:56, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[中西 正], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.歯学部 [継承]
著者 (必須): 1. (英) Ernst, W. Cory (日) (読)
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[継承]
2. (英) Lee, Eun Jang (日) (読)
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3.中西 正 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.臨床歯学系.歯科保存学]/[徳島大学.病院.診療科.歯科.むし歯科(第一保存科)])
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[継承]
4. (英) Karimbux, Y. Nadeem (日) (読)
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[継承]
5. (英) Rezende, M. Taia (日) (読)
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[継承]
6. (英) Stashenko, Philip (日) (読)
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7.関 誠 ([三菱ウェルファーマ 株式会社])
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8.Taubman Martin ([The Forsyth Institute, Department of Immunology])
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[継承]
9.河井 敬久 ([The Forsyth Institute, Department of Immunology])
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題名 (必須): (英) Diminished forkhead box P3/CD25 double-positive T regulatory cells are associated with the increased nuclear factor-kB ligand (RANKL(+)) T cells in bone resorption lesion of periodontal disease  (日)    [継承]
副題 (任意):
要約 (任意): (英) Periodontal disease involves multi-bacterial infections accompanied by inflammatory bone resorption lesions. The abundant T and B lymphocyte infiltrates are the major sources of the osteoclast differentiation factor, receptor activator for nuclear factor-kappaB ligand (RANKL) which, in turn, contributes to the development of bone resorption in periodontal disease. In the present study, we found that the concentrations of RANKL and regulatory T cell (T(reg))-associated cytokine, interleukin (IL)-10, in the periodontal tissue homogenates were correlated negatively, whereas RANKL and proinflammatory cytokine, IL-1beta, showed positive correlation. Also, according to the fluorescent-immunohistochemistry, the frequency of forkhead box P3 (FoxP3)/CD25 double-positive cells was diminished strikingly in the bone resorption lesion of periodontal disease compared to healthy gingival tissue, while CD25 or FoxP3 single positive cells were still observed in lesions where abundant RANKL+ lymphocytes were present. Very importantly, few or no expressions of FoxP3 by the RANKL+ lymphocytes were observed in the diseased periodontal tissues. Finally, IL-10 suppressed both soluble RANKL (sRANKL) and membrane RANKL (mRANKL) expression by peripheral blood mononuclear cells (PBMC) activated in vitro in a bacterial antigen-specific manner. Taken together, these results suggested that FoxP3/CD25 double-positive T(reg) cells may play a role in the down-regulation of RANKL expression by activated lymphocytes in periodontal diseased tissues. This leads to the conclusion that the phenomenon of diminished CD25+FoxP3+ T(reg) cells appears to be associated with the increased RANKL+ T cells in the bone resorption lesion of periodontal disease.  (日)    [継承]
キーワード (推奨): 1. (英) FoxP3 (日) (読) [継承]
2. (英) periodontal/oral immunology (日) (読) [継承]
3. (英) RANKL (日) (読) [継承]
4. (英) T cells (日) (読) [継承]
5. (英) Treg cells (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Clinical and Experimental Immunology (British Society for Immunology)
(pISSN: 0009-9104, eISSN: 1365-2249)

ISSN (任意): 0009-9104
ISSN: 0009-9104 (pISSN: 0009-9104, eISSN: 1365-2249)
Title: Clinical and experimental immunology
Title(ISO): Clin. Exp. Immunol.
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2007年 5月 初日 (平成 19年 5月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2249.2006.03318.x    (→Scopusで検索) [継承]
PMID (任意): 17355249    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Immunology, The Forsyth Institute, Boston, MA 02115, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]
4.(英) OtherID: PMC1868884  (日)    [継承]

標準的な表示

和文冊子 ● Cory W. Ernst, Jang Eun Lee, Tadashi Nakanishi, Nadeem Y. Karimbux, Taia M. Rezende, Philip Stashenko, Makoto Seki, Martin A Taubman and Toshihisa Kawai : Diminished forkhead box P3/CD25 double-positive T regulatory cells are associated with the increased nuclear factor-kB ligand (RANKL(+)) T cells in bone resorption lesion of periodontal disease, Clinical and Experimental Immunology, Vol.148, No.2, 271-280, 2007.
欧文冊子 ● Cory W. Ernst, Jang Eun Lee, Tadashi Nakanishi, Nadeem Y. Karimbux, Taia M. Rezende, Philip Stashenko, Makoto Seki, Martin A Taubman and Toshihisa Kawai : Diminished forkhead box P3/CD25 double-positive T regulatory cells are associated with the increased nuclear factor-kB ligand (RANKL(+)) T cells in bone resorption lesion of periodontal disease, Clinical and Experimental Immunology, Vol.148, No.2, 271-280, 2007.

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