| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.創薬資源科学部門.資源分子探索学講座 (2004年4月1日〜)
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| ○著者 (必須): | 1. | (英) Horiuch, Masafumi (日) (読)
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| 2. | (英) Murakami, Chihiro (日) (読)
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| 3. | (英) Fukamiya, Narihiko (日) (読)
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| 4. | (英) Yu, Donglei (日) (読)
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| 5. | (英) Chen, Tzu-Hsuan (日) (読)
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| 6. | (英) Bastow, Kenneth F. (日) (読)
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| 7. | (英) Zhang, De-Cheng (日) (読)
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| 8. | 高石 喜久 ([徳島大学.デザイン型AI教育研究センター])
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| 9. | (英) Imakura, Yasuhiro (日) (読)
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| 10. | (英) Lee, Kuo-Hsiung (日) (読)
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| ○題名 (必須): | □ | (英) Tripfordines A-C, Sesquiterpene Pyridine Alkaloids from Tripterygium wilfordii, and Structure Anti-HIV Activity Relationships of Tripterygium Alkaloids (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Three new sesquiterpene pyridine alkaloids, tripfordines A-C (1-3), were isolated from an ethanolic extract of the roots of Tripterygium wilfordii, along with eight known pyridine alkaloids, and tested for in vitro cytotoxic and anti-HIV activity. The structures of the new compounds were established on the basis of spectroscopic data interpretation. Anti-HIV structure-activity relationships (SAR) for this compound type are proposed on the basis of the screening results from the newly isolated compounds and prior data of known sesquiterpene pyridine alkaloids. The position of a carboxyalkyl chain on the pyridine moiety was not critical since both 2'- and 4'-substituted compounds exhibited high anti-HIV activity (EC(50) 0.1 microg/mL). In contrast, a hydroxy group at C-8' (carboxypropyl side chain) or C-9' (carboxybutyl side chain) was found to affect anti-HIV activity. (日)
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| ○キーワード (推奨): | 1. | (英) Alkaloids (日) (読)
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| 2. | (英) Anti-HIV Agents (日) (読)
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| 3. | (英) Drugs, Chinese Herbal (日) (読)
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| 4. | (英) Molecular Structure (日) (読)
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| 5. | (英) Plant Bark (日) (読)
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| 6. | (英) Plant Roots (日) (読)
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| 7. | (英) Plants, Medicinal (日) (読)
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| 8. | (英) Pyridines (日) (読)
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| 9. | (英) Sesquiterpenes (日) (読)
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| 10. | (英) Structure-Activity Relationship (日) (読)
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| 11. | (英) Tripterygium (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Natural Products ([アメリカ化学会])
(pISSN: 0163-3864, eISSN: 1520-6025)
| ○ISSN (任意): | □ | 0163-3864
ISSN: 0163-3864
(pISSN: 0163-3864, eISSN: 1520-6025) Title: Journal of natural productsTitle(ISO): J Nat ProdPublisher: American Chemical Society (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 69
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 1271 1274
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2006年 9月 初日 (平成 18年 9月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1021/np060124a (→Scopusで検索)
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| ○PMID (任意): | □ | 16989518 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima 739-8521, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural (日)
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