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EID=162971EID:162971, Map:0, LastModified:2013年4月30日(火) 21:30:17, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[田中 克哉], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.Medical College of Wisconsin [継承]
著者 (必須): 1. (英) Chiari PC (日) (読)
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2. (英) Pagel PS (日) (読)
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3.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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[継承]
4. (英) Krolikowski JG (日) (読)
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[継承]
5. (英) Ludwig LM (日) (読)
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6. (英) Trillo RA (日) (読)
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7. (英) Puri N (日) (読)
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8. (英) Kersten JR (日) (読)
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9. (英) Warltier DC (日) (読)
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題名 (必須): (英) Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Preconditioning against myocardial infarction by volatile anesthetics is well known. The authors tested the hypothesis that new emulsified formulations of halogenated anesthetics administered intravenously reduce myocardial infarct size when administered either 1 or 24 h before prolonged ischemia and reperfusion. Pentobarbital-anesthetized rabbits (n = 39) were instrumented for measurement of hemodynamics and randomly assigned to receive intravenous saline (control), lipid vehicle, or infusions (3.5 ml . kg . h for 30 min) of emulsified isoflurane (6.9%), enflurane (7.1%), or sevoflurane (7.5%). Infusions were discontinued 30 min before a 30-min coronary occlusion and 3 h of reperfusion. In three additional groups, conscious rabbits (n = 21) received saline, lipid vehicle, or emulsified sevoflurane (7.5%) infusions (3.5 ml . kg . h for 30 min) 24 h before ischemia and reperfusion. Infarct size was determined using triphenyltetrazolium staining. Lipid vehicle produced transient increases in heart rate, whereas emulsified volatile anesthetics had no effect on hemodynamics before coronary occlusion. Lipid vehicle did not affect infarct size (38 +/- 2% of the area at risk; mean +/- SEM) as compared with saline control (41 +/- 4%). In contrast, emulsified isoflurane, enflurane, and sevoflurane reduced infarct size (20 +/- 3%, 20 +/- 3%, and 21 +/- 2% of the area at risk, respectively; P < 0.05). Administration of lipid vehicle or emulsified sevoflurane did not produce sedation or respiratory depression in conscious rabbits. Emulsified sevoflurane (18 +/- 2%) but not lipid vehicle (44 +/- 2%) reduced infarct size as compared with control in delayed preconditioning experiments. Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction.  (日)    [継承]
キーワード (推奨): 1. (英) Anesthetics, Inhalation (日) (読) [継承]
2. (英) Anesthetics, Intravenous (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Blood Gas Analysis (日) (読) [継承]
5. (英) Chemistry, Pharmaceutical (日) (読) [継承]
6. (英) Emulsions (日) (読) [継承]
7. (英) Enflurane (日) (読) [継承]
8. (英) Excipients (日) (読) [継承]
9. (英) Hemodynamics (日) (読) [継承]
10. (英) Ischemic Preconditioning, Myocardial (日) (読) [継承]
11. (英) Isoflurane (日) (読) [継承]
12. (英) Male (日) (読) [継承]
13. (英) Methyl Ethers (日) (読) [継承]
14. (英) Myocardial Infarction (日) (読) [継承]
15. (英) Myocardial Reperfusion Injury (日) (読) [継承]
16. (英) Myocardium (日) (読) [継承]
17. (英) Rabbits (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anesthesiology ([The American Society of Anesthesiologists])
(pISSN: 0003-3022, eISSN: 1528-1175)

ISSN (任意): 0003-3022
ISSN: 0003-3022 (pISSN: 0003-3022, eISSN: 1528-1175)
Title: Anesthesiology
Title(ISO): Anesthesiology
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 1160 1166 [継承]
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年月日 (必須): 西暦 2004年 11月 初日 (平成 16年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1097/00000542-200411000-00016    (→Scopusで検索) [継承]
PMID (任意): 15505452    (→Scopusで検索) [継承]
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評価値 (任意): **** [制限]
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備考 (任意): 1.(英) Article.Affiliation: Department of Anesthesiology and Pharmacology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● PC Chiari, PS Pagel, Katsuya Tanaka, JG Krolikowski, LM Ludwig, RA Trillo, N Puri, JR Kersten and DC Warltier : Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits., Anesthesiology, Vol.101, No.5, 1160-1166, 2004.
欧文冊子 ● PC Chiari, PS Pagel, Katsuya Tanaka, JG Krolikowski, LM Ludwig, RA Trillo, N Puri, JR Kersten and DC Warltier : Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits., Anesthesiology, Vol.101, No.5, 1160-1166, 2004.

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