『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=162970EID:162970, Map:0, LastModified:2012年9月4日(火) 14:08:53, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[田中 克哉], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.Medical College of Wisconsin [継承]
著者 (必須): 1. (英) Ludwig LM (日) (読)
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学籍番号 (推奨):
[継承]
2.田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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[継承]
3. (英) Eelles JT (日) (読)
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[継承]
4. (英) Weihrauch D (日) (読)
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[継承]
5. (英) Pagel PS (日) (読)
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[継承]
6. (英) Kersten JR (日) (読)
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[継承]
7. (英) Warltier DC (日) (読)
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[継承]
題名 (必須): (英) Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Reactive oxygen species (ROS) mediate volatile anesthetic preconditioning. We tested the hypothesis that isoflurane (ISO) generates ROS from electron transport chain complexes I and III. Rabbits (n = 55) underwent 30 min coronary artery occlusion followed by 3 h reperfusion and received 0.9% saline, the complex I inhibitor diphenyleneiodonium (DPI; 1.5 mg/kg bolus followed by 1.5 mg/kg over 1 h), or the complex III inhibitor myxothiazol (MYX; 0.1 mg/kg bolus followed by 0.3 mg/kg over 1 h) in the absence and presence of 1.0 minimum alveolar concentration ISO. ISO was administered for 30 min and discontinued 15 min before coronary occlusion. Infarct size and ROS production (n = 32) were determined using triphenyltetrazolium staining and ethidium-DNA fluorescence, respectively. Adenosine triphosphate (ATP) synthesis in mitochondria obtained from rabbit hearts (n = 24) subjected to drug interventions was measured by luciferin-luciferase luminometry. ISO significantly (P < 0.05) reduced infarct size (19% +/- 4%) as compared with control (39% +/- 4%). MYX (35% +/- 4%), but not DPI (24% +/- 2%), abolished this protection. ISO increased ethidium-DNA fluorescence (83 +/- 11 U) as compared with control (40 +/- 12 U). MYX (35 +/- 3 U), but not DPI (78 +/- 9 U), abolished ROS generation. DPI and MYX selectively reduced complex I- and complex III-mediated ATP synthesis, respectively. ROS generated from electron transport chain complex III mediate ISO-induced cardioprotection.  (日)    [継承]
キーワード (推奨): 1. (英) Adenosine Triphosphate (日) (読) [継承]
2. (英) Anesthetics, Inhalation (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Coenzymes (日) (読) [継承]
5. (英) Electron Transport (日) (読) [継承]
6. (英) Enzyme Inhibitors (日) (読) [継承]
7. (英) Hemodynamics (日) (読) [継承]
8. (英) Ischemic Preconditioning, Myocardial (日) (読) [継承]
9. (英) Isoflurane (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Methacrylates (日) (読) [継承]
12. (英) Mitochondria, Heart (日) (読) [継承]
13. (英) Myocardial Infarction (日) (読) [継承]
14. (英) NADH Dehydrogenase (日) (読) [継承]
15. (英) Onium Compounds (日) (読) [継承]
16. (英) Rabbits (日) (読) [継承]
17. (英) Reactive Oxygen Species (日) (読) [継承]
18. (英) Thiazoles (日) (読) [継承]
19. (英) Ubiquinone (日) (読) [継承]
20. (英) Ventricular Function, Left (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Anesthesia & Analgesia (International Anesthesia Research Society(IARS))
(pISSN: 0003-2999, eISSN: 1526-7598)

ISSN (任意): 0003-2999
ISSN: 0003-2999 (pISSN: 0003-2999, eISSN: 1526-7598)
Title: Anesthesia and analgesia
Title(ISO): Anesth Analg
Publisher: Lippincott Williams & Wilkins Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 99 [継承]
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(必須): 1308 1315 [継承]
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年月日 (必須): 西暦 2004年 11月 初日 (平成 16年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1213/01.ANE.0000134804.09484.5D    (→Scopusで検索) [継承]
PMID (任意): 15502022    (→Scopusで検索) [継承]
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評価値 (任意): **** [制限]
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備考 (任意): 1.(英) Article.Affiliation: Medical College of Wisconsin, MEB-M4280, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: In Vitro  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● LM Ludwig, Katsuya Tanaka, JT Eelles, D Weihrauch, PS Pagel, JR Kersten and DC Warltier : Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III., Anesthesia & Analgesia, Vol.99, No.5, 1308-1315, 2004.
欧文冊子 ● LM Ludwig, Katsuya Tanaka, JT Eelles, D Weihrauch, PS Pagel, JR Kersten and DC Warltier : Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III., Anesthesia & Analgesia, Vol.99, No.5, 1308-1315, 2004.

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