| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): | □ | 研究
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| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | Medical College of Wisconsin
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| ○著者 (必須): | 1. | (英) Ludwig LM (日) (読)
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| 2. | 田中 克哉 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.麻酔・疼痛治療医学]/[徳島大学.病院.診療科.脳·神経·精神科])
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| 3. | (英) Eelles JT (日) (読)
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| 4. | (英) Weihrauch D (日) (読)
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| 5. | (英) Pagel PS (日) (読)
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| 6. | (英) Kersten JR (日) (読)
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| 7. | (英) Warltier DC (日) (読)
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| ○題名 (必須): | □ | (英) Preconditioning by isoflurane is mediated by reactive oxygen species generated from mitochondrial electron transport chain complex III. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Reactive oxygen species (ROS) mediate volatile anesthetic preconditioning. We tested the hypothesis that isoflurane (ISO) generates ROS from electron transport chain complexes I and III. Rabbits (n = 55) underwent 30 min coronary artery occlusion followed by 3 h reperfusion and received 0.9% saline, the complex I inhibitor diphenyleneiodonium (DPI; 1.5 mg/kg bolus followed by 1.5 mg/kg over 1 h), or the complex III inhibitor myxothiazol (MYX; 0.1 mg/kg bolus followed by 0.3 mg/kg over 1 h) in the absence and presence of 1.0 minimum alveolar concentration ISO. ISO was administered for 30 min and discontinued 15 min before coronary occlusion. Infarct size and ROS production (n = 32) were determined using triphenyltetrazolium staining and ethidium-DNA fluorescence, respectively. Adenosine triphosphate (ATP) synthesis in mitochondria obtained from rabbit hearts (n = 24) subjected to drug interventions was measured by luciferin-luciferase luminometry. ISO significantly (P < 0.05) reduced infarct size (19% +/- 4%) as compared with control (39% +/- 4%). MYX (35% +/- 4%), but not DPI (24% +/- 2%), abolished this protection. ISO increased ethidium-DNA fluorescence (83 +/- 11 U) as compared with control (40 +/- 12 U). MYX (35 +/- 3 U), but not DPI (78 +/- 9 U), abolished ROS generation. DPI and MYX selectively reduced complex I- and complex III-mediated ATP synthesis, respectively. ROS generated from electron transport chain complex III mediate ISO-induced cardioprotection. (日)
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| ○キーワード (推奨): | 1. | (英) Adenosine Triphosphate (日) (読)
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| 2. | (英) Anesthetics, Inhalation (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Coenzymes (日) (読)
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| 5. | (英) Electron Transport (日) (読)
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| 6. | (英) Enzyme Inhibitors (日) (読)
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| 7. | (英) Hemodynamics (日) (読)
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| 8. | (英) Ischemic Preconditioning, Myocardial (日) (読)
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| 9. | (英) Isoflurane (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Methacrylates (日) (読)
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| 12. | (英) Mitochondria, Heart (日) (読)
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| 13. | (英) Myocardial Infarction (日) (読)
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| 14. | (英) NADH Dehydrogenase (日) (読)
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| 15. | (英) Onium Compounds (日) (読)
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| 16. | (英) Rabbits (日) (読)
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| 17. | (英) Reactive Oxygen Species (日) (読)
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| 18. | (英) Thiazoles (日) (読)
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| 19. | (英) Ubiquinone (日) (読)
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| 20. | (英) Ventricular Function, Left (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Anesthesia & Analgesia (International Anesthesia Research Society(IARS))
(pISSN: 0003-2999, eISSN: 1526-7598)
| ○ISSN (任意): | □ | 0003-2999
ISSN: 0003-2999
(pISSN: 0003-2999, eISSN: 1526-7598) Title: Anesthesia and analgesiaTitle(ISO): Anesth AnalgPublisher: Lippincott Williams & Wilkins Ltd. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 99
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 1308 1315
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 11月 初日 (平成 16年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1213/01.ANE.0000134804.09484.5D (→Scopusで検索)
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| ○PMID (任意): | □ | 15502022 (→Scopusで検索)
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| ○NAID (任意): |
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| ○評価値 (任意): | □ | ****
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Medical College of Wisconsin, MEB-M4280, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: In Vitro (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S. (日)
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