| ○種別 (必須): | □ | 学術論文 (審査論文)
| [継承] |
| ○言語 (必須): | □ | 英語
| [継承] |
| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
| [継承] |
| ○カテゴリ (推奨): | □ | 研究
| [継承] |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.医療栄養科学講座 (2004年4月1日〜)
| [継承] |
| ○著者 (必須): | 1. | (英) Koshiba K (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 2. | 野村 昌弘
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 3. | 中屋 豊
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| 4. | 伊東 進
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
| [継承] |
| ○題名 (必須): | □ | (英) Efficacy of glimepiride on insulin resistance adipocytokines and atherosclerosis. (日)
| [継承] |
| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Plasma adiponectin levels increase after the administration of glimepiride. This unique effects would also be expected to improve other adipocytokines and have anti-atherosclerotic action in patients with metabolic syndrome. Thirty-four patients with type 2 diabetes mellitus who were administrated glibenclamide were randomly divided into two groups. In 20 patients glibenclamide was changed to glimepiride (GP group), and the administration of glibenclamide (GB group) was continued in 14 patients. Twelve patients receiving insulin therapy (INS group) were enrolled for comparison. The levels of plasma adiponectin, high sensitive-CRP, TNF-alpha, interleukin-6, homeostasis model assessment-insulin resistance (HOMA-IR), brachial-ankle pulse wave velocity (baPWV) and augmentation index (AI) were measured before and 28 weeks after the therapy. HOMA-IR in the GP group was significantly decreased compared to the GB group. Plasma adiponectin levels were significantly increased in the GP group but not in the other groups. TNF-alpha, interleukin-6 and high sensitive-CRP levels were significantly decreased in the GP group, but not in the other groups. The baPWV and AI levels did not change in either the GB or the INS group, but were significantly decreased in the GP group. Glimepiride appears to improve insulin resistance and atherosclerotic disorders. (日)
| [継承] |
| ○キーワード (推奨): | 1. | (英) Adipocytes (日) (読)
| [継承] |
| 2. | (英) Aged (日) (読)
| [継承] |
| 3. | 動脈硬化 (atherosclerosis)
| [継承] |
| 4. | 細胞質分裂 (cytokinesis)
| [継承] |
| 5. | (英) Diabetes Mellitus, Type 2 (日) (読)
| [継承] |
| 6. | (英) Female (日) (読)
| [継承] |
| 7. | (英) Glyburide (日) (読)
| [継承] |
| 8. | (英) Humans (日) (読)
| [継承] |
| 9. | (英) Hypoglycemic Agents (日) (読)
| [継承] |
| 10. | (英) Inflammation Mediators (日) (読)
| [継承] |
| 11. | インスリン抵抗性 (insulin resistance)
| [継承] |
| 12. | (英) Male (日) (読)
| [継承] |
| 13. | (英) Metabolic Syndrome X (日) (読)
| [継承] |
| 14. | (英) Middle Aged (日) (読)
| [継承] |
| 15. | (英) Sulfonylurea Compounds (日) (読)
| [継承] |
| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)
| ○ISSN (任意): | □ | 1343-1420
ISSN: 1343-1420
(pISSN: 1343-1420, eISSN: 1349-6867) Title: The journal of medical investigation : JMITitle(ISO): J Med InvestSupplier: 徳島大学Publisher: University of Tokushima (NLM Catalog)
(Webcat Plus)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
| [継承] |
| ○巻 (必須): | □ | 53
| [継承] |
| ○号 (必須): | □ | 1-2
| [継承] |
| ○頁 (必須): | □ | 87 94
| [継承] |
| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2006年 2月 初日 (平成 18年 2月 初日)
| [継承] |
| ○URL (任意): |
| ○DOI (任意): | □ | 10.2152/jmi.53.87 (→Scopusで検索)
| [継承] |
| ○PMID (任意): | □ | 16538000 (→Scopusで検索)
| [継承] |
| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-33645801431
| [継承] |
| ○機関リポジトリ : | □ | 110792
| [継承] |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Digestive and Cardiovascular Medicine, The University of Tokushima Graduate School, Japan. (日)
| [継承] |
| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
| [継承] |
| 3. | (英) Article.PublicationTypeList.PublicationType: Randomized Controlled Trial (日)
| [継承] |